| FABP4 concentrations should be taken into consideration as an early marker of kidney damage in patients with type 2 diabetes. | Plasma fatty acid-binding protein 4 increases with renal dysfunction in type 2 diabetic patients without microalbuminuria.
Cabré A, Lázaro I, Girona J, Manzanares JM, Marimón F, Plana N, Heras M, Masana L. | 01/21/2010 |
| thiazolidinedione increases FABP4 plasma concentrations in diabetic patients, reflecting PPARgamma activation | Fatty acid binding protein 4 is increased in metabolic syndrome and with thiazolidinedione treatment in diabetic patients.
Cabré A, Lázaro I, Girona J, Manzanares JM, Marimón F, Plana N, Heras M, Masana L. | 01/21/2010 |
| Hypoxia enhances the expression of FABP4 in term human trophoblasts, suggesting that fatty acid binding proteins support fat accumulation in the hypoxic placenta. | Hypoxia regulates the expression of fatty acid-binding proteins in primary term human trophoblasts.
Biron-Shental T, Schaiff WT, Ratajczak CK, Bildirici I, Nelson DM, Sadovsky Y., Free PMC Article | 01/21/2010 |
| These data indicate for the first time that human macrophage aP2 promoter is a direct target for the regulation by LXR/RXR heterodimers. | Adipocyte fatty acid-binding protein (aP2), a newly identified LXR target gene, is induced by LXR agonists in human THP-1 cells.
Liu QY, Quinet E, Nambi P. | 01/21/2010 |
| observations suggest that oxLDL-mediated increase in gene expression accelerate cholesterol ester accumulation, and that this is an important component of the genetic program regulating conversion of macrophages to foam cells | The adipocyte lipid binding protein (ALBP/aP2) gene facilitates foam cell formation in human THP-1 macrophages.
Fu Y, Luo N, Lopes-Virella MF, Garvey WT. | 01/21/2010 |
| intra-pair correlations revealed that FATP4 expression was signifcantly up-regulated in acquired obesity. | Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance.
Gertow K, Pietiläinen KH, Yki-Järvinen H, Kaprio J, Rissanen A, Eriksson P, Hamsten A, Fisher RM. | 01/21/2010 |
| Data demonstrate a significant genetic variation in humans that results in decreased adipose tissue aP2 expression due to alteration of the CAAT box/enhancer-binding protein binding and reduced transcriptional activity of the aP2 promoter. | A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease.
Tuncman G, Erbay E, Hom X, De Vivo I, Campos H, Rimm EB, Hotamisligil GS., Free PMC Article | 01/21/2010 |
| the metallothionein genes, adipophilin (ADFP), CD36, adipocyte fatty acid binding protein (FABP4), ATP binding cassette protein A1 (ABCA1), and liver X receptor (LXR[alpha]) all emerged as strongly positively correlated with PPAR[gamma] expression. | Predominance of a proinflammatory phenotype in monocyte-derived macrophages from subjects with low plasma HDL-cholesterol.
Sarov-Blat L, Kiss RS, Haidar B, Kavaslar N, Jaye M, Bertiaux M, Steplewski K, Hurle MR, Sprecher D, McPherson R, Marcel YL. | 01/21/2010 |
| ALBP gene expression accelerates cholesterol and triglyceride accumulation in macrophage foam cells and affects some key gene expression for lipid metabolism. | Lipid metabolism mediated by adipocyte lipid binding protein (ALBP/aP2) gene expression in human THP-1 macrophages.
Fu Y, Luo L, Luo N, Garvey WT. | 01/21/2010 |
| genetic variability at the FABP4 locus has been shown to be associated with plasma lipid levels, type 2 diabetes, and coronary heart disease risk | Identification of a functional polymorphism at the adipose fatty acid binding protein gene (FABP4) and demonstration of its association with cardiovascular disease: a path to follow.
Ordovas JM. | 01/21/2010 |
| a pre-lipolysis complex containing at least AFABP and HSL exists | Physical association between the adipocyte fatty acid-binding protein and hormone-sensitive lipase: a fluorescence resonance energy transfer analysis.
Smith AJ, Sanders MA, Thompson BR, Londos C, Kraemer FB, Bernlohr DA. | 01/21/2010 |
| Loss of expression of A-FABP is associated with progression of bladder carcinoma. | Loss of expression of the adipocyte-type fatty acid-binding protein (A-FABP) is associated with progression of human urothelial carcinomas.
Ohlsson G, Moreira JM, Gromov P, Sauter G, Celis JE. | 01/21/2010 |
| Expression occurs not only in mature adipocytes, but has a wider embryonic expression pattern than previously appreciated. | Selective expression of an aP2/Fatty Acid Binding Protein 4-Cre transgene in non-adipogenic tissues during embryonic development.
Urs S, Harrington A, Liaw L, Small D. | 01/21/2010 |
| Changes in DNA methylation at adipogenic promoters during cellular aging. | Dynamics of adipogenic promoter DNA methylation during clonal culture of human adipose stem cells to senescence.
Noer A, Boquest AC, Collas P., Free PMC Article | 01/21/2010 |
| fatty acid binding protein 4 and PPARgamma work together to influence a biologic pathway affecting insulin sensitivity and body composition | Genetic variation in fatty acid-binding protein-4 and peroxisome proliferator-activated receptor gamma interactively influence insulin sensitivity and body composition in males.
Damcott CM, Moffett SP, Feingold E, Barmada MM, Marshall JA, Hamman RF, Ferrell RE. | 01/21/2010 |
| FABP4 protein is expressed within the skeletal muscle fibers & FABP4 mRNA & protein are more abundant in the endurance trained subjects.[fatty acid binding protein 4] | Fatty acid binding protein 4 in human skeletal muscle.
Fischer H, Gustafsson T, Sundberg CJ, Norrbom J, Ekman M, Johansson O, Jansson E. | 01/21/2010 |