| tumor samples from FMTC patients showed strong nuclear staining of phosphorylated ERK1/2 and Ser(727) STAT3; FMTC-RET mutants activate a Ras/ERK1/2/STAT3 Ser(727) pathway, which plays an important role in cell mitogenicity and transformation. | Ras/ERK1/2-mediated STAT3 Ser727 phosphorylation by familial medullary thyroid carcinoma-associated RET mutants induces full activation of STAT3 and is required for c-fos promoter activation, cell mitogenicity, and transformation.
Plaza-Menacho I, van der Sluis T, Hollema H, Gimm O, Buys CH, Magee AI, Isacke CM, Hofstra RM, Eggen BJ. | 01/21/2010 |
| Myocardial STAT3 protein levels are reduced and serum levels of activated cathepsin D and 16 kDa prolactin are elevated in postpartum cardiomyopathy patients. | A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy.
Hilfiker-Kleiner D, Kaminski K, Podewski E, Bonda T, Schaefer A, Sliwa K, Forster O, Quint A, Landmesser U, Doerries C, Luchtefeld M, Poli V, Schneider MD, Balligand JL, Desjardins F, Ansari A, Struman I, Nguyen NQ, Zschemisch NH, Klein G, Heusch G, Schulz R, Hilfiker A, Drexler H. | 01/21/2010 |
| CYCLIN D1 may be a target gene for leptin mediated growth stimulation of breast cancer cells and molecular mechanisms involve activated Stat3 | leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3.
Saxena NK, Vertino PM, Anania FA, Sharma D., Free PMC Article | 01/21/2010 |
| IL-10 induces IL-10 in monocyte-derived macrophages in an autocrine manner via activation of the transcription factor Stat3. | IL-10 induces IL-10 in primary human monocyte-derived macrophages via the transcription factor Stat3.
Staples KJ, Smallie T, Williams LM, Foey A, Burke B, Foxwell BM, Ziegler-Heitbrock L. | 01/21/2010 |
| The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through its dephosphorylation. | The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation.
Yamamoto T, Sekine Y, Kashima K, Kubota A, Sato N, Aoki N, Matsuda T. | 01/21/2010 |
| constitutive activation of Akt and NFkappaB, but not Stat3, contributes significantly to the progression of diffuse gliomas | Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas.
Wang H, Wang H, Zhang W, Huang HJ, Liao WS, Fuller GN. | 01/21/2010 |
| STAT5b-RARalpha and other APL fusion proteins may contribute to leukemogenesis by interaction with the STAT3 oncogene pathway. | Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways.
Dong S, Tweardy DJ. | 01/21/2010 |
| THE presence of this protein and its phosphorylated derivative in node-negative breast cancer shows nuclear localization is associated with a better prognosis. | Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis.
Dolled-Filhart M, Camp RL, Kowalski DP, Smith BL, Rimm DL. | 01/21/2010 |
| Results indicate that SOCS-7 is a dysregulator of prolactin, leptin, and growth hormone signaling and that its mode of action is a variation of SOCS protein inhibition of cytokine-inducible STAT3 and 5-mediated signal transduction. | Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation.
Martens N, Uzan G, Wery M, Hooghe R, Hooghe-Peters EL, Gertler A. | 01/21/2010 |
| extracellular signal-dependent nuclear transport of STAT3 is mediated by various importin alphas, importin beta, and Ran | Extracellular signal-dependent nuclear import of STAT3 is mediated by various importin alphas.
Ushijima R, Sakaguchi N, Kano A, Maruyama A, Miyamoto Y, Sekimoto T, Yoneda Y, Ogino K, Tachibana T. | 01/21/2010 |
| results demonstrate for the first time that prostacyclin receptor activation by cicaprost can lead to STAT1 and STAT3 phosphorylations via signaling pathways involving pertussis toxin-insensitive G proteins, ERK and JNK | Prostacyclin receptor induces STAT1 and STAT3 phosphorylations in human erythroleukemia cells: a mechanism requiring PTX-insensitive G proteins, ERK and JNK.
Lo RK, Wise H, Wong YH. | 01/21/2010 |
| Atiprimod blocked Stat3 activation and inhibited colony-forming cell proliferation in acute myeloid leukemia cells. | Atiprimod blocks phosphorylation of JAK-STAT and inhibits proliferation of acute myeloid leukemia (AML) cells.
Faderl S, Ferrajoli A, Harris D, Van Q, Kantarjian HM, Estrov Z. | 01/21/2010 |
| there is a cross-talk between the NFkappaB and the STAT3 signaling systems, and HNSCC may result from the aberrant activity of a signaling network | Molecular cross-talk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma.
Squarize CH, Castilho RM, Sriuranpong V, Pinto DS Jr, Gutkind JS., Free PMC Article | 01/21/2010 |
| The Ras/Raf-1/MEK1/ERK cascade culminates in nicotine up-regulated expression of the gene encoding STAT-3, whereas recruitment and activation of tyrosine kinase JAK-2 phosphorylates it. | Receptor-mediated tobacco toxicity: cooperation of the Ras/Raf-1/MEK1/ERK and JAK-2/STAT-3 pathways downstream of alpha7 nicotinic receptor in oral keratinocytes.
Arredondo J, Chernyavsky AI, Jolkovsky DL, Pinkerton KE, Grando SA. | 01/21/2010 |
| Activated STAT3 translocates to the nucleus of KSHV-infected endothelial cells, where it can bind to STAT3-specific DNA elements and can activate STAT3-dependent promoter activity. | Persistent activation of STAT3 by latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells.
Punjabi AS, Carroll PA, Chen L, Lagunoff M., Free PMC Article | 01/21/2010 |
| activation of STAT3 may play an important role in the tumorigenesis of gastric adenocarcinoma | Expression of p-STAT3 in human gastric carcinoma: significant correlation in tumour invasion and prognosis.
Yakata Y, Nakayama T, Yoshizaki A, Kusaba T, Inoue K, Sekine I. | 01/21/2010 |
| let-7a modulates interleukin-6-dependent STAT-3 survival signaling in malignant human cholangiocytes | The MicroRNA let-7a modulates interleukin-6-dependent STAT-3 survival signaling in malignant human cholangiocytes.
Meng F, Henson R, Wehbe-Janek H, Smith H, Ueno Y, Patel T. | 01/21/2010 |
| SOCS-3 epigenetic silencing is responsible for sustained IL-6/STAT-3 signaling and enhanced Mcl-1 expression in cholangiocarcinoma | Sustained IL-6/STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencing.
Isomoto H, Mott JL, Kobayashi S, Werneburg NW, Bronk SF, Haan S, Gores GJ., Free PMC Article | 01/21/2010 |
| findings suggest that activated STAT3 signaling directly contributes to malignant progression of primary effusion lymphoma by preventing apoptosis, acting through the prosurvival protein survivin | Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma.
Aoki Y, Feldman GM, Tosato G. | 01/21/2010 |
| Differentiation-dependent expression of STAT3 may modify responses to growth factors in the cancers of the head and neck. | Differentiation-dependent expression of signal transducers and activators of transcription (STATs) might modify responses to growth factors in the cancers of the head and neck.
Arany I, Chen SH, Megyesi JK, Adler-Storthz K, Chen Z, Rajaraman S, Ember IA, Tyring SK, Brysk MM. | 01/21/2010 |
| Although the data show that STAT3 is required for the majority of IL-10 functions, there are elements of the anti-inflammatory activity of IL-10 that are STAT3 independent. | Signal transducer and activator of transcription 3 is the dominant mediator of the anti-inflammatory effects of IL-10 in human macrophages.
Williams L, Bradley L, Smith A, Foxwell B. | 01/21/2010 |
| expression of STAT-3 induced by Epstein-Barr virus (EBV) LMP-1 (latent membrane protein) and may be part of the viral programming that regulates viral latency and cellular transformation | Multiple signal transducers and activators of transcription are induced by EBV LMP-1.
Zhang L, Hong K, Zhang J, Pagano JS. | 01/21/2010 |
| Stat3 mediated by c-Met is frequently associated with the progression of oral squamous cell carcinoma | Constitutive activation of Stat3 correlates with increased expression of the c-Met/HGF receptor in oral squamous cell carcinoma.
Klosek SK, Nakashiro K, Hara S, Li C, Shintani S, Hamakawa H. | 01/21/2010 |
| Coordination between Stat1 & Stat3 activation determines GTPCH I induction. Stat1 & NF-B activation, coordinated with the lack of Stat3 activation, accounts for cytokine-stimulated GTPCH I induction in endothelial cells. | Cytokine-stimulated GTP cyclohydrolase I expression in endothelial cells requires coordinated activation of nuclear factor-kappaB and Stat1/Stat3.
Huang A, Zhang YY, Chen K, Hatakeyama K, Keaney JF Jr. | 01/21/2010 |
| interacts with dengue-2 virus NS1 protein | Recombinant non-structural 1 (NS1) protein of dengue-2 virus interacts with human STAT3beta protein.
Chua JJ, Bhuvanakantham R, Chow VT, Ng ML. | 01/21/2010 |