| the c-src kinase/STAT3 pathway has a role in Ox-PAPC-mediated IL-8 expression in endothelial cells | Oxidized phospholipids increase interleukin 8 (IL-8) synthesis by activation of the c-src/signal transducers and activators of transcription (STAT)3 pathway.
Yeh M, Gharavi NM, Choi J, Hsieh X, Reed E, Mouillesseaux KP, Cole AL, Reddy ST, Berliner JA. | 01/21/2010 |
| a profound in vivo activation of STAT3 is observed in mycosis fungoides (MF) tumors but not in the early stages of MF. STAT3 protects tumor cells from apoptosis in vitro. Taken together, these findings suggest that STAT3 is a malignancy factor in CTCL. | In vivo activation of STAT3 in cutaneous T-cell lymphoma. Evidence for an antiapoptotic function of STAT3.
Sommer VH, Clemmensen OJ, Nielsen O, Wasik M, Lovato P, Brender C, Eriksen KW, Woetmann A, Kaestel CG, Nissen MH, Ropke C, Skov S, Ødum N. | 01/21/2010 |
| Results provide evidence that interleukin-13 induces p38 MAP kinase phosphorylation and activation, which regulates Stat1 and Stat3 serine 727 phosphorylation. | Interleukin-13 induction of 15-lipoxygenase gene expression requires p38 mitogen-activated protein kinase-mediated serine 727 phosphorylation of Stat1 and Stat3.
Xu B, Bhattacharjee A, Roy B, Xu HM, Anthony D, Frank DA, Feldman GM, Cathcart MK., Free PMC Article | 01/21/2010 |
| We found that the amino terminal domain of STP A11 is required for both STAT3 interaction and activation, and that physical interaction is required for STAT3 activation. | Herpesvirus saimiri STP A11 protein interacts with STAT3 and stimulates its transcriptional activity.
Park J, Seo T, Jung J, Choe J. | 01/21/2010 |
| data reveal an important role for MgcRacGAP in STAT3 activation, and demonstrate that MgcRacGAP regulates IL-6-induced cellular differentiation in which STAT3 plays a pivotal role | A GTPase-activating protein binds STAT3 and is required for IL-6-induced STAT3 activation and for differentiation of a leukemic cell line.
Tonozuka Y, Minoshima Y, Bao YC, Moon Y, Tsubono Y, Hatori T, Nakajima H, Nosaka T, Kawashima T, Kitamura T. | 01/21/2010 |
| identification of tip60 as a co-repressor for STAT3 | Tip60 is a co-repressor for STAT3.
Xiao H, Chung J, Kao HY, Yang YC. | 01/21/2010 |
| STST3 activation is mediated by EGFR and c-Src and facilitated by Pyk2 | Pyk2 amplifies epidermal growth factor and c-Src-induced Stat3 activation.
Shi CS, Kehrl JH. | 01/21/2010 |
| Data show that medroxyprogesterone acetate treatment of mammary tumor cells up-regulated Stat3 protein expression and induced rapid, nongenomic Stat3, Jak1, and Jak2 tyrosine phosphorylation. | Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells.
Proietti C, Salatino M, Rosemblit C, Carnevale R, Pecci A, Kornblihtt AR, Molinolo AA, Frahm I, Charreau EH, Schillaci R, Elizalde PV., Free PMC Article | 01/21/2010 |
| STAT3-mediated transcriptional activation in inhibited by Daxx | Physical and functional interactions between Daxx and STAT3.
Muromoto R, Nakao K, Watanabe T, Sato N, Sekine Y, Sugiyama K, Oritani K, Shimoda K, Matsuda T. | 01/21/2010 |
| Stat3 is involved in keloid pathogenesis. Inhibitors of Stat3 may be useful therapeutic strategies for the prospective treatment of keloid scars. | Stat3 contributes to keloid pathogenesis via promoting collagen production, cell proliferation and migration.
Lim CP, Phan TT, Lim IJ, Cao X. | 01/21/2010 |
| Haplotypes of STAT3 predict cardiovascular disease in renal dialysis patients. | Haplotype of signal transducer and activator of transcription 3 gene predicts cardiovascular disease in dialysis patients.
Zhang L, Kao WH, Berthier-Schaad Y, Liu Y, Plantinga L, Jaar BG, Fink N, Powe N, Klag MJ, Smith MW, Coresh J. | 01/21/2010 |
| Mechanism by which hepcidin can be regulated by inflammation or, in the absence of inflammatory stimuli, by alternative mechanisms leading to STAT3 activation. | Interleukin-6 induces hepcidin expression through STAT3.
Wrighting DM, Andrews NC., Free PMC Article | 01/21/2010 |
| To determine the prosurvival function of STAT3 vs STAT5 within the same tumor model, genes were profiled in STAT3- or STAT5-depleted human lymphoblastic lymphoma-derived cell line YT cells by apoptosis-specific microarrays | A preferential role for STAT5, not constitutively active STAT3, in promoting survival of a human lymphoid tumor.
Nagy ZS, Rui H, Stepkowski SM, Karras J, Kirken RA. | 01/21/2010 |
| antitumor activity of S3I-201 is mediated in part through inhibition of aberrant Stat3 activation | Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity.
Siddiquee K, Zhang S, Guida WC, Blaskovich MA, Greedy B, Lawrence HR, Yip ML, Jove R, McLaughlin MM, Lawrence NJ, Sebti SM, Turkson J., Free PMC Article | 01/21/2010 |
| in addition to activating NF-kappaB/p52, LIGHT also activates Stat3 through the NIK pathway | LIGHT, a member of the TNF superfamily, activates Stat3 mediated by NIK pathway.
Nadiminty N, Chun JY, Hu Y, Dutt S, Lin X, Gao AC., Free PMC Article | 01/21/2010 |