| YB-1 overexpression can induce EGF independence in human mammary epithelial cells via activation of the EGFR pathway | Y-box-binding protein 1 confers EGF independence to human mammary epithelial cells.
Berquin IM, Pang B, Dziubinski ML, Scott LM, Chen YQ, Nolan GP, Ethier SP. | 01/21/2010 |
| interacts with JCV agnoprotein to modulate transcriptional activity of JCV promoters | Functional interaction between JC virus late regulatory agnoprotein and cellular Y-box binding transcription factor, YB-1.
Safak M, Sadowska B, Barrucco R, Khalili K., Free PMC Article | 01/21/2010 |
| data suggest that p73 stimulates the transcription of the YB-1 promoter by enhancing recruitment of the c-Myc-Max complex to the E-box | p73 Interacts with c-Myc to regulate Y-box-binding protein-1 expression.
Uramoto H, Izumi H, Ise T, Tada M, Uchiumi T, Kuwano M, Yasumoto K, Funa K, Kohno K. | 01/21/2010 |
| autoregulation of YB-1 mRNA translation via the 5'-UTR | Characterization of the 5'-untranslated region of YB-1 mRNA and autoregulation of translation by YB-1 protein.
Fukuda T, Ashizuka M, Nakamura T, Shibahara K, Maeda K, Izumi H, Kohno K, Kuwano M, Uchiumi T., Free PMC Article | 01/21/2010 |
| YB-1 is involved in base excision and mismatch repair pathways | YB-1 promotes strand separation in vitro of duplex DNA containing either mispaired bases or cisplatin modifications, exhibits endonucleolytic activities and binds several DNA repair proteins.
Gaudreault I, Guay D, Lebel M., Free PMC Article | 01/21/2010 |
| Nuclear localization of this protein requires wild-type p53. | Nuclear localization of Y-box factor YB1 requires wild-type p53.
Zhang YF, Homer C, Edwards SJ, Hananeia L, Lasham A, Royds J, Sheard P, Braithwaite AW. | 01/21/2010 |
| Hepatic nuclear factor 3 and nuclear factor 1 regulate 5-aminolevulinate synthase gene expression and are involved in insulin repression | Hepatic nuclear factor 3 and nuclear factor 1 regulate 5-aminolevulinate synthase gene expression and are involved in insulin repression.
Scassa ME, Guberman AS, Ceruti JM, Cánepa ET. | 01/21/2010 |
| The central and C-terminal domains of YB-1 are required for specific binding to 8-oxoguanine-containing RNA, a mechanism that involves sequestering oxidatively damaged RNA from normal processes and contributes to the high fidelity of translation in cells. | Binding capacity of human YB-1 protein for RNA containing 8-oxoguanine.
Hayakawa H, Uchiumi T, Fukuda T, Ashizuka M, Kohno K, Kuwano M, Sekiguchi M. | 01/21/2010 |
| YB-1 functions under the regulation of GATA factors in erythroid differentiation and aberrant expression of YB-1 gene may result in dyserythropoiesis | Regulation of YB-1 gene expression by GATA transcription factors.
Yokoyama H, Harigae H, Takahashi S, Takahashi S, Furuyama K, Kaku M, Yamamoto M, Sasaki T. | 01/21/2010 |
| findings suggested that YB-1 functions in the early stage of erythropoiesis and that aberrant expression of this protein may induce hematological diseases such as MDS | High expression of YB-1 gene in erythroid cells in patients with refractory anemia.
Yokoyama H, Harigae H, Takahashi S, Kameoka J, Miyamura K, Ishizawa K, Kaku M, Sasaki T. | 01/21/2010 |
| FRGY2a and YB1 disassemble nucleoli by sequestering B23, which is associated with pre-ribosomes and other structurally important nucleolar components | Requirement of the protein B23 for nucleolar disassembly induced by the FRGY2a family proteins.
Gonda K, Wudel J, Nelson D, Katoku-Kikyo N, Reed P, Tamada H, Kikyo N., Free PMC Article | 01/21/2010 |
| 5-HTT VNTR domains differentially respond to YB-1 which binds to the VNTR in a sequence-specific manner-- a new mechanism explaining the ability of the distinct VNTR copy numbers to support differential reporter expression based on YB-1 binding sites. | YB-1 and CTCF differentially regulate the 5-HTT polymorphic intron 2 enhancer which predisposes to a variety of neurological disorders.
Klenova E, Scott AC, Roberts J, Shamsuddin S, Lovejoy EA, Bergmann S, Bubb VJ, Royer HD, Quinn JP., Free PMC Article | 01/21/2010 |
| study demonstrates that NF-1 plays an important role in PMA/IL-1-mediated transactivation of the JC virus early promoter; suggests a possible involvement of NF-1 in JC virus reactivation in immunosuppressive states such as AIDS | Transcriptional activation of JC virus early promoter by phorbol ester and interleukin-1beta: critical role of nuclear factor-1.
Kim SY, Choi EC, Woo Jo Y, Henson JW, Kim HS. | 01/21/2010 |
| Nuclear expression of YB-1 protein correlates with P-glycoprotein expression in human breast carcinoma. | Nuclear expression of YB-1 protein correlates with P-glycoprotein expression in human breast carcinoma.
Saji H, Toi M, Saji S, Koike M, Kohno K, Kuwano M. | 01/21/2010 |
| conclusion, the data demonstrate the utility of the analyzed RNAs as powerful laboratory tools and indicate that YB-1 is not involved in the regulation of the MDR1 gene. | Regulation of MDR1 gene expression in multidrug-resistant cancer cells is independent from YB-1.
Kaszubiak A, Kupstat A, Müller U, Hausmann R, Holm PS, Lage H. | 01/21/2010 |
| YB-1 expression is correlated with PCNA expression in NSCLC. The DNA repair pathway and tumor proliferation mediated by YB-1 linking to PCNA may be responsible for controlling the growth of NSCLC. | Y-box-binding protein-1 expression is not correlated with p53 expression but with proliferating cell nuclear antigen expression in non-small cell lung cancer.
Yoshimatsu T, Uramoto H, Oyama T, Yashima Y, Gu C, Morita M, Sugio K, Kohno K, Yasumoto K. | 01/21/2010 |
| interacts with an upstream element in the alpha1(I) collagen gene | A member of the Y-box protein family interacts with an upstream element in the alpha1(I) collagen gene.
Sun W, Hou F, Panchenko MP, Smith BD. | 01/21/2010 |
| YB-1 mediates DNA polymerase alpha gene expression | Transcription factor YB-1 mediates DNA polymerase alpha gene expression.
En-Nia A, Yilmaz E, Klinge U, Lovett DH, Stefanidis I, Mertens PR. | 01/21/2010 |
| YB-1 is a cell cycle stage-specific transcription factor important for cell proliferation | YB-1 as a cell cycle-regulated transcription factor facilitating cyclin A and cyclin B1 gene expression.
Jurchott K, Bergmann S, Stein U, Walther W, Janz M, Manni I, Piaggio G, Fietze E, Dietel M, Royer HD. | 01/21/2010 |
| nuclear YB-1 shuttling and alternative splice site selection is regulated by SRp30c interaction with YB-1 | Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection.
Raffetseder U, Frye B, Rauen T, Jürchott K, Royer HD, Jansen PL, Mertens PR. | 01/21/2010 |
| Overexpression of a transfected gene encoding YB-1 in human HeLa cervical carcinoma cells significantly represses the transactivation of a minimal AP-1 reporter construct in response to the tumour promoter PMA. | YB-1 represses AP1-dependent gene transactivation and interacts with an AP-1 DNA sequence.
Samuel S, Twizere JC, Bernstein LR., Free PMC Article | 01/21/2010 |
| NSEP1 is an authentic selenocysteine insertion sequence binding protein that is structurally associated with the selenoprotein translation complex and functionally involved in the translation of selenoproteins in mammalian cells | Nuclease sensitive element binding protein 1 associates with the selenocysteine insertion sequence and functions in mammalian selenoprotein translation.
Shen Q, Fan L, Newburger PE., Free PMC Article | 01/21/2010 |
| YB-1 colocalized with P-body (messenger RNA processing bodies) | Probing the mRNA processing body using protein macroarrays and "autoantigenomics".
Yang WH, Bloch DB., Free PMC Article | 01/21/2010 |
| YB-1 relocates to the nucleus in adenovirus-infected cells and facilitates viral replication | YB-1 relocates to the nucleus in adenovirus-infected cells and facilitates viral replication by inducing E2 gene expression through the E2 late promoter.
Holm PS, Bergmann S, Jurchott K, Lage H, Brand K, Ladhoff A, Mantwill K, Curiel DT, Dobbelstein M, Dietel M, Gansbacher B, Royer HD. | 01/21/2010 |
| NMR structure and DNA-binding properties of the cold-shock domain of the human Y-box protein YB-1 | The solution structure and DNA-binding properties of the cold-shock domain of the human Y-box protein YB-1.
Kloks CP, Spronk CA, Lasonder E, Hoffmann A, Vuister GW, Grzesiek S, Hilbers CW. | 01/21/2010 |