| The insertion of amino acid exchanges into the kinase inhibitory regions of SOCS-1 demonstrated a requirement of these domains for a proper inhibitory function. | SOCS-1 and SOCS-3 inhibit IL-4 and IL-13 induced activation of Eotaxin-3/CCL26 gene expression in HEK293 cells.
Hebenstreit D, Luft P, Schmiedlechner A, Duschl A, Horejs-Hoeck J. | 01/21/2010 |
| Data suggest that SOCS1 functions as a negative regulator in TNF-induced inflammation and activation of c-jun N-terminal kinase in endothelial cells, in part by inducing ASK1 degradation. | SOCS1 inhibits tumor necrosis factor-induced activation of ASK1-JNK inflammatory signaling by mediating ASK1 degradation.
He Y, Zhang W, Zhang R, Zhang H, Min W. | 01/21/2010 |
| elevated expression of SOCS genes is a specific lesion of breast-cancer cells that may confer resistance to proinflammatory cytokines and trophic factors, by shutting down STAT1/STAT5 signaling that mediate essential functions in the mammary gland | Expression of SOCS1 and SOCS3 genes is differentially regulated in breast cancer cells in response to proinflammatory cytokine and growth factor signals.
Evans MK, Yu CR, Lohani A, Mahdi RM, Liu X, Trzeciak AR, Egwuagu CE. | 01/21/2010 |
| Methylation of SOCS1 was absent in both AML and ALL patients. Frequent methylation of SHP1, but not SOCS1, may be important in the pathogenesis, but not prognosis, of acute leukaemias. | Epigenetic dysregulation of the Jak/STAT pathway by frequent aberrant methylation of SHP1 but not SOCS1 in acute leukaemias.
Chim CS, Wong AS, Kwong YL. | 01/21/2010 |
| this gene is silenced in a substantial portion of pancreatic cancers through mechanisms that cause methylation in the promoter region | Hypermethylation-associated inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human pancreatic cancers.
Komazaki T, Nagai H, Emi M, Terada Y, Yabe A, Jin E, Kawanami O, Konishi N, Moriyama Y, Naka T, Kishimoto T. | 01/21/2010 |
| inhibits interferon-gamma-induced activation of human keratinocytes | Suppressor of cytokine signaling-1 inhibits interferon-gamma-induced activation of human keratinocytes.
Albanesi C, Federici M, Giustizieri ML, Scarponi C, Girolomoni G. | 01/21/2010 |
| Aberrant methylation of SOCS-1 may be associated with hepatocarcinogenesis. | Methylation status of suppressor of cytokine signaling-1 gene in hepatocellular carcinoma.
Miyoshi H, Fujie H, Moriya K, Shintani Y, Tsutsumi T, Makuuchi M, Kimura S, Koike K. | 01/21/2010 |
| loss of SOCS-1 function either by mutation or by the complete deletion of the gene plays an important role in the dysregulation of JAK/STAT signaling in Karpas1106P and primary mediastinal b-cell lymphoma | Biallelic deletion within 16p13.13 including SOCS-1 in Karpas1106P mediastinal B-cell lymphoma line is associated with delayed degradation of JAK2 protein.
Melzner I, Weniger MA, Bucur AJ, Brüderlein S, Dorsch K, Hasel C, Leithäuser F, Ritz O, Dyer MJ, Barth TF, Möller P. | 01/21/2010 |
| Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation | Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation.
Weniger MA, Melzner I, Menz CK, Wegener S, Bucur AJ, Dorsch K, Mattfeldt T, Barth TF, Möller P. | 01/21/2010 |
| These results in our study indicates gene silencing of SOCS1 remarkably enhanced the cytotoxicity efficiency of CML28 DNA vaccine in DCs. | Induction of CML28-specific cytotoxic T cell responses using co-transfected dendritic cells with CML28 DNA vaccine and SOCS1 small interfering RNA expression vector.
Zhou H, Zhang D, Wang Y, Dai M, Zhang L, Liu W, Liu D, Tan H, Huang Z. | 01/21/2010 |
| Up-regulation of suppressor of cytokine signaling 1 is associated with adult T-cell leukemia | Down-regulation of SHP1 and up-regulation of negative regulators of JAK/STAT signaling in HTLV-1 transformed cell lines and freshly transformed human peripheral blood CD4+ T-cells.
Cheng J, Zhang D, Zhou C, Marasco WA. | 01/21/2010 |
| Three functional STAT6- interferon-gamma-activated sequence-binding motifs situated close to each other 600 bp upstream of the SOCS-1 transcriptional initiation site mediate IL-4-IL-13-induced SOCS-1 transcription. | IL-4 and IL-13 induce SOCS-1 gene expression in A549 cells by three functional STAT6-binding motifs located upstream of the transcription initiation site.
Hebenstreit D, Luft P, Schmiedlechner A, Regl G, Frischauf AM, Aberger F, Duschl A, Horejs-Hoeck J. | 01/21/2010 |