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    CALCOCO2 calcium binding and coiled-coil domain 2 [ Homo sapiens (human) ]

    Gene ID: 10241, updated on 6-Oct-2024

    GeneRIFs: Gene References Into Functions

    Submit: New GeneRIFCorrection

    GeneRIFPubMed TitleDate
    the role of ORF75 in the antagonization of ND10-mediated intrinsic immunity

    Kaposi's sarcoma associated herpesvirus tegument protein ORF75 is essential for viral lytic replication and plays a critical role in the antagonization of ND10-instituted intrinsic immunity.
    Full F, Jungnickl D, Reuter N, Bogner E, Brulois K, Scholz B, Stürzl M, Myoung J, Jung JU, Stamminger T, Ensser A., Free PMC Article

    		02/14/2015
    Dimeric NDP52 forms a ternary complex with two monomeric galectin-8 molecules as well as two LC3C molecules

    Structural basis for recognition of autophagic receptor NDP52 by the sugar receptor galectin-8.
    Kim BW, Hong SB, Kim JH, Kwon DH, Song HK.

    		10/26/2013
    The missense SNP rs2303015 (Val248Ala) in the NDP52 was associated with Crohn's disease.

    Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies.
    Ellinghaus D, Zhang H, Zeissig S, Lipinski S, Till A, Jiang T, Stade B, Bromberg Y, Ellinghaus E, Keller A, Rivas MA, Skieceviciene J, Doncheva NT, Liu X, Liu Q, Jiang F, Forster M, Mayr G, Albrecht M, Häsler R, Boehm BO, Goodall J, Berzuini CR, Lee J, Andersen V, Vogel U, Kupcinskas L, Kayser M, Krawczak M, Nikolaus S, Weersma RK, Ponsioen CY, Sans M, Wijmenga C, Strachan DP, McArdle WL, Vermeire S, Rutgeerts P, Sanderson JD, Mathew CG, Vatn MH, Wang J, Nöthen MM, Duerr RH, Büning C, Brand S, Glas J, Winkelmann J, Illig T, Latiano A, Annese V, Halfvarson J, D'Amato M, Daly MJ, Nothnagel M, Karlsen TH, Subramani S, Rosenstiel P, Schreiber S, Parkes M, Franke A., Free PMC Article

    		09/28/2013
    Data indicate that the binding site in galectin-8 is essential for the recruitment of the autophagy receptor NDP52 to cytosol-exposed Salmonella Typhimurium.

    Sterical hindrance promotes selectivity of the autophagy cargo receptor NDP52 for the danger receptor galectin-8 in antibacterial autophagy.
    Li S, Wandel MP, Li F, Liu Z, He C, Wu J, Shi Y, Randow F., Free PMC Article

    		07/27/2013
    Autophagy of Tax1bp1/Ndp52 promotes non-canonical NF-kappaB signalling.

    TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signalling.
    Newman AC, Scholefield CL, Kemp AJ, Newman M, McIver EG, Kamal A, Wilkinson S., Free PMC Article

    		05/25/2013
    Data show that the selectivity of the autophagy receptor NDP52 for LC3C is crucial for innate immunity since cells lacking either protein cannot protect their

    LC3C, bound selectively by a noncanonical LIR motif in NDP52, is required for antibacterial autophagy.
    von Muhlinen N, Akutsu M, Ravenhill BJ, Foeglein Á, Bloor S, Rutherford TJ, Freund SM, Komander D, Randow F., Free PMC Article

    		02/9/2013
    Data show that the miRNA-processing enzyme, DICER and the main miRNA effector, AGO2, are targeted for degradation as miRNA-free entities

    Selective autophagy degrades DICER and AGO2 and regulates miRNA activity.
    Gibbings D, Mostowy S, Jay F, Schwab Y, Cossart P, Voinnet O., Free PMC Article

    		02/2/2013
    a selective autophagic mechanism mediated by NDP52 that works downstream of TRIF-TRAF6.

    Regulation of Toll-like receptor signaling by NDP52-mediated selective autophagy is normally inactivated by A20.
    Inomata M, Niida S, Shibata K, Into T., Free PMC Article

    		04/7/2012
    p62 and NDP52 act cooperatively to drive efficient antibacterial autophagy by targeting the protein complexes they coordinate to distinct microdomains associated with bacteria

    The ubiquitin-binding adaptor proteins p62/SQSTM1 and NDP52 are recruited independently to bacteria-associated microdomains to target Salmonella to the autophagy pathway.
    Cemma M, Kim PK, Brumell JH., Free PMC Article

    		12/31/2011
    p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways.

    p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways.
    Mostowy S, Sancho-Shimizu V, Hamon MA, Simeone R, Brosch R, Johansen T, Cossart P., Free PMC Article

    		10/1/2011
    ND10 and ND10 components might be important defensive factors against the CMV cross-species infection

    Functional interaction of nuclear domain 10 and its components with cytomegalovirus after infections: cross-species host cells versus native cells.
    Cosme RC, Martínez FP, Tang Q., Free PMC Article

    		08/27/2011
    NDP52 recognizes ubiquitin-coated Salmonella enterica and recruits TBK1.

    The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria.
    Thurston TL, Ryzhakov G, Bloor S, von Muhlinen N, Randow F.

    		01/21/2010
    NDP52 was identified as a myosin VI binding protein; results suggest that myosin VI-T6BP-NDP52 complexes may play a role in coordinating cytokine signalling and membrane transport pathways with actin filament organisation and cell adhesion

    T6BP and NDP52 are myosin VI binding partners with potential roles in cytokine signalling and cell adhesion.
    Morriswood B, Ryzhakov G, Puri C, Arden SD, Roberts R, Dendrou C, Kendrick-Jones J, Buss F., Free PMC Article

    		01/21/2010
    interacts with ICP4 regulatory protein of HSV-1 during early stage of infection

    Formation of nuclear foci of the herpes simplex virus type 1 regulatory protein ICP4 at early times of infection: localization, dynamics, recruitment of ICP27, and evidence for the de novo induction of ND10-like complexes.
    Everett RD, Sourvinos G, Leiper C, Clements JB, Orr A., Free PMC Article

    		01/21/2010
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