| in systemic lupus erythematosus (SLE) patients, observed an inhibitory effect of ILT4 on the immunogenic capability of Dendritic cells (DC); ILT4 was shown not to have a crucial role in regulating maturation and function of DC from healthy controls but is partially involved in maturation process and immunogenic capability of DC from SLE patients | Analysis of the Expression and Function of Immunoglobulin-Like Transcript 4 (ILT4, LILRB2) in Dendritic Cells from Patients with Systemic Lupus Erythematosus.
Guerra-de Blas Pdel C, Villaseñor-Talavera YS, Cruz-González Dde J, Baranda L, Doníz-Padilla L, Abud-Mendoza C, González-Amaro R, Monsiváis-Urenda AE., Free PMC Article | 11/12/2016 |
| Data indicate Ig-like transcript 4 (ILT4) as a cellular receptor for complement split products (CSPs) complement component 4d (C4d). | Ig-like transcript 4 as a cellular receptor for soluble complement fragment C4d.
Hofer J, Forster F, Isenman DE, Wahrmann M, Leitner J, Hölzl MA, Kovarik JJ, Stockinger H, Böhmig GA, Steinberger P, Zlabinger GJ. | 08/27/2016 |
| signaling involving ANGPTL2 and LILRB2 is important for lung cancer development | ANGPTL2/LILRB2 signaling promotes the propagation of lung cancer cells.
Liu X, Yu X, Xie J, Zhan M, Yu Z, Xie L, Zeng H, Zhang F, Chen G, Yi X, Zheng J., Free PMC Article | 06/28/2016 |
| High MicroRNA-10b promotes migration and invasion in gastric cancer. | MicroRNA-10b promotes migration and invasion through Hoxd10 in human gastric cancer.
Wang YY, Li L, Ye ZY, Zhao ZS, Yan ZL., Free PMC Article | 06/11/2016 |
| Findings suggest that ILT4 drives NSCLC development in part on activation of ERK signaling which in turn upregulates VEGF-C. | Immunoglobulin-like transcript 4 promotes tumor progression and metastasis and up-regulates VEGF-C expression via ERK signaling pathway in non-small cell lung cancer.
Zhang P, Guo X, Li J, Yu S, Wang L, Jiang G, Yang D, Wei Z, Zhang N, Liu J, Sun Y., Free PMC Article | 04/23/2016 |
| Data show that the leukocyte antigen G HLA-G alpha1-alpha3 structure, which constitutes the extracellular part of HLA-G2 and HLA-G6, binds the immunologic receptor LILRB2 but not LILRB1. | Multimeric structures of HLA-G isoforms function through differential binding to LILRB receptors.
HoWangYin KY, Loustau M, Wu J, Alegre E, Daouya M, Caumartin J, Sousa S, Horuzsko A, Carosella ED, LeMaoult J., Free PMC Article | 11/21/2015 |
| Data show that immunoglobulin-like transcript 4 (ILT4) increases the expression of the co-inhibitory molecule B7-H3 through PI3K/AKT/mTOR signalling. | ILT4 drives B7-H3 expression via PI3K/AKT/mTOR signalling and ILT4/B7-H3 co-expression correlates with poor prognosis in non-small cell lung cancer.
Zhang P, Yu S, Li H, Liu C, Li J, Lin W, Gao A, Wang L, Gao W, Sun Y. | 10/31/2015 |
| involvement of ILT3 and ILT4 in the modulation of immune responsiveness in multiple sclerosis by both interferon and vitamin D | Interferon beta and vitamin D synergize to induce immunoregulatory receptors on peripheral blood monocytes of multiple sclerosis patients.
Waschbisch A, Sanderson N, Krumbholz M, Vlad G, Theil D, Schwab S, Mäurer M, Derfuss T., Free PMC Article | 09/12/2015 |
| A novel motif in the first and fourth Ig domains of LILRB2 was identified that is necessary for the receptor to be bound and activated by Angptl2. | A motif in LILRB2 critical for Angptl2 binding and activation.
Deng M, Lu Z, Zheng J, Wan X, Chen X, Hirayasu K, Sun H, Lam Y, Chen L, Wang Q, Song C, Huang N, Gao GF, Jiang Y, Arase H, Zhang CC., Free PMC Article | 05/2/2015 |
| PIRB and LILRB2 were expressed in mouse and human platelets, respectively. | Paired immunoglobulin-like receptor B regulates platelet activation.
Fan X, Shi P, Dai J, Lu Y, Chen X, Liu X, Zhang K, Wu X, Sun Y, Wang K, Zhu L, Zhang CC, Zhang J, Chen GQ, Zheng J, Liu J., Free PMC Article | 03/7/2015 |
| ILT4 was found to be highly expressed in primary human ductal and lobular breast cancer cells, and its expression was significantly correlated with more IL-10 expression. | Inhibitory receptor immunoglobulin-like transcript 4 was highly expressed in primary ductal and lobular breast cancer and significantly correlated with IL-10.
Liu J, Wang L, Gao W, Li L, Cui X, Yang H, Lin W, Dang Q, Zhang N, Sun Y., Free PMC Article | 01/3/2015 |
| we propose an impact of LILRB2 on HIV-1 disease outcomes through altered regulation of DCs by LILRB2-HLA engagement | LILRB2 interaction with HLA class I correlates with control of HIV-1 infection.
Bashirova AA, Martin-Gayo E, Jones DC, Qi Y, Apps R, Gao X, Burke PS, Taylor CJ, Rogich J, Wolinsky S, Bream JH, Duggal P, Hussain S, Martinson J, Weintrob A, Kirk GD, Fellay J, Buchbinder SP, Goedert JJ, Deeks SG, Pereyra F, Trowsdale J, Lichterfeld M, Telenti A, Walker BD, Allen RL, Carrington M, Yu XG., Free PMC Article | 11/29/2014 |
| These data support a bystander role for the miR-10 family in NPM1 mutated acute myeloid leukemia | Implications of the miR-10 family in chemotherapy response of NPM1-mutated AML.
Havelange V, Ranganathan P, Geyer S, Nicolet D, Huang X, Yu X, Volinia S, Kornblau SM, Andreeff M, Croce CM, Marcucci G, Bloomfield CD, Garzon R., Free PMC Article | 06/7/2014 |
| we report the crystal structures of the D3D4 domains of both LILRB1 and LILRB2. | Crystal structures of the two membrane-proximal Ig-like domains (D3D4) of LILRB1/B2: alternative models for their involvement in peptide-HLA binding.
Nam G, Shi Y, Ryu M, Wang Q, Song H, Liu J, Yan J, Qi J, Gao GF., Free PMC Article | 05/10/2014 |
| Upregulation of the inhibitory receptor ILT4 in monocytes from septic patients. | Upregulation of the inhibitory receptor ILT4 in monocytes from septic patients.
Baffari E, Fiume D, Caiazzo G, Sinistro A, Natoli S, Almerighi C, Calò-Carducci F, Leonardis F, Bergamini A. | 03/29/2014 |
| Exocytosis acts as a modulator of the ILT4-mediated inhibition of neutrophil functions. | Exocytosis acts as a modulator of the ILT4-mediated inhibition of neutrophil functions.
Baudhuin J, Migraine J, Faivre V, Loumagne L, Lukaszewicz AC, Payen D, Favier B., Free PMC Article | 01/11/2014 |
| These findings imply that LilrB2 contributes to human Alzheimer's disease neuropathology and suggest therapeutic uses of blocking LilrB2 function. | Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model.
Kim T, Vidal GS, Djurisic M, William CM, Birnbaum ME, Garcia KC, Hyman BT, Shatz CJ., Free PMC Article | 10/26/2013 |
| IL-10 up-regulates ILT4 expression on monocytes via increasing ILT4 gene promoter activity. | IL-10 enhances promoter activity of ILT4 gene and up-regulates its expression in THP-1 cells.
Xu X, Zou P, Chen L, Jin G, Zhou H. | 04/13/2013 |
| Data suggest that when CD1c is up-regulated, ILT4 is recruited to CD1c, thus reducing the inhibitory effect of immunoglobulin-like transcript 4 (ILT4) on CD1d recognition. | A novel role of CD1c in regulating CD1d-mediated NKT cell recognition by competitive binding to Ig-like transcript 4.
Li D, Hong A, Lu Q, Gao GF, Jin B, Screaton GR, Xu XN. | 04/13/2013 |
| Cyclosporine up-regulated the expression of ILT3 and ILT4 on natural killer cells, which influenced their cytotoxicity against tumor cells. | Cyclosporine induces up-regulation of immunoglobulin-like transcripts 3 and 4 expression on and activity of NKL cells.
Si YQ, Bian XK, Lu N, Jia YF, Hou ZH, Zhang Y. | 09/22/2012 |
| B27 H chain dimers and multimers are stronger ligands for LILRB2 than HLA class I heterotrimers and H chains | HLA-B27 homodimers and free H chains are stronger ligands for leukocyte Ig-like receptor B2 than classical HLA class I.
Giles J, Shaw J, Piper C, Wong-Baeza I, McHugh K, Ridley A, Li D, Lenart I, Antoniou AN, DiGleria K, Kuroki K, Maenaka K, Bowness P, Kollnberger S., Free PMC Article | 08/18/2012 |
| study indicates an unexpected functional significance of classical immune-inhibitory receptors in maintenance of stemness of normal adult stem cells and in support of cancer development | Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development.
Zheng J, Umikawa M, Cui C, Li J, Chen X, Zhang C, Huynh H, Kang X, Silvany R, Wan X, Ye J, Cantó AP, Chen SH, Wang HY, Ward ES, Zhang CC., Free PMC Article | 07/14/2012 |
| LILRA3 binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1/LILRB2 | LILRA3 binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1/LILRB2: structural evidence.
Ryu M, Chen Y, Qi J, Liu J, Fan Z, Nam G, Shi Y, Cheng H, Gao GF., Free PMC Article | 12/3/2011 |
| Inhibitory receptors LILRB1 and LILRB2 vary in their level of binding to different HLA alleles, correlating in some cases with specific amino acid motifs. | HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding.
Jones DC, Kosmoliaptsis V, Apps R, Lapaque N, Smith I, Kono A, Chang C, Boyle LH, Taylor CJ, Trowsdale J, Allen RL. | 05/21/2011 |
| Soluble HLA-G inhibits myeloid dendritic cell function in HIV-1 infection by interacting with leukocyte immunoglobulin-like receptor B2. | Soluble HLA-G inhibits myeloid dendritic cell function in HIV-1 infection by interacting with leukocyte immunoglobulin-like receptor B2.
Huang J, Burke P, Yang Y, Seiss K, Beamon J, Cung T, Toth I, Pereyra F, Lichterfeld M, Yu XG., Free PMC Article | 01/15/2011 |