| High follistatin expression is associated with lung adenocarcinoma. | High circulating activin A level is associated with tumor progression and predicts poor prognosis in lung adenocarcinoma.
Hoda MA, Rozsas A, Lang E, Klikovits T, Lohinai Z, Torok S, Berta J, Bendek M, Berger W, Hegedus B, Klepetko W, Renyi-Vamos F, Grusch M, Dome B, Laszlo V., Free PMC Article | 12/16/2017 |
| FST and KLK6 may have significance in breast cancer detection | An integrated cell line-based discovery strategy identified follistatin and kallikrein 6 as serum biomarker candidates of breast carcinoma.
Mangé A, Dimitrakopoulos L, Soosaipillai A, Coopman P, Diamandis EP, Solassol J. | 11/26/2017 |
| Follistatin and activin A are higher in MI than in CAD suggesting increased release due to myocardial necrosis. They can predict MI with accuracy similar to CK-MB | Circulating irisin levels are lower in patients with either stable coronary artery disease (CAD) or myocardial infarction (MI) versus healthy controls, whereas follistatin and activin A levels are higher and can discriminate MI from CAD with similar to CK-MB accuracy.
Anastasilakis AD, Koulaxis D, Kefala N, Polyzos SA, Upadhyay J, Pagkalidou E, Economou F, Anastasilakis CD, Mantzoros CS. | 10/7/2017 |
| The activin-A to follistatin ratio may play a role in determining the clinical phenotype of preterm birth as preterm labor or preterm premature rupture of membranes. | Imbalance of Amniotic Fluid Activin-A and Follistatin in Intraamniotic Infection, Inflammation, and Preterm Birth.
Hardy JT, Buhimschi IA, McCarthy ME, Zhao G, Laky CA, Shook LL, Buhimschi CS., Free PMC Article | 07/8/2017 |
| Low follistatin expression is associated with liver cirrhosis. | Impaired Follistatin Secretion in Cirrhosis.
Rinnov AR, Plomgaard P, Pedersen BK, Gluud LL. | 06/24/2017 |
| Within the nonalcoholic fatty liver disease group of patients, follistatin was associated with steatohepatitis independently from activin A | Activin A and follistatin in patients with nonalcoholic fatty liver disease.
Polyzos SA, Kountouras J, Anastasilakis AD, Triantafyllou GΑ, Mantzoros CS., Free PMC Article | 05/20/2017 |
| Follistatin levels are associated with circulating leptin levels and display a day-night rhythm and a menstrual cycle, but not a seasonal, variation. | Circulating follistatin displays a day-night rhythm and is associated with muscle mass and circulating leptin levels in healthy, young humans.
Anastasilakis AD, Polyzos SA, Skouvaklidou EC, Kynigopoulos G, Saridakis ZG, Apostolou A, Triantafyllou GA, Karagiozoglou-Lampoudi T, Mantzoros CS., Free PMC Article | 05/20/2017 |
| annexin A2 but not follistatin is expressed in hepatocellular carcinoma | Evaluation of annexin A2 and as potential biomarkers for hepatocellular carcinoma.
El-Abd N, Fawzy A, Elbaz T, Hamdy S. | 02/18/2017 |
| FST plays a role in tumourigenesis, metastasis and angiogenesis of solid tumours through its interaction with activin and BMPs, thus resulting in pathophysiological function. In terms of diagnosis, prognosis and therapy, FST has shown strong promise | Clinical and Therapeutic Implications of Follistatin in Solid Tumours.
Shi L, Resaul J, Owen S, Ye L, Jiang WG., Free PMC Article | 01/28/2017 |
| Study shows that INHBA and FST are induced by seminal fluid in cervical tissues and thus, may contribute to regulation of the post-coital response in women. | Seminal fluid factors regulate activin A and follistatin synthesis in female cervical epithelial cells.
Sharkey DJ, Schjenken JE, Mottershead DG, Robertson SA. | 10/8/2016 |
| Circulating follistatin may be a marker of the glucagon-to-insulin tone on the liver | Circulating Follistatin Is Liver-Derived and Regulated by the Glucagon-to-Insulin Ratio.
Hansen JS, Rutti S, Arous C, Clemmesen JO, Secher NH, Drescher A, Gonelle-Gispert C, Halban PA, Pedersen BK, Weigert C, Bouzakri K, Plomgaard P. | 07/2/2016 |
| serum concentrations positively associated with serum free thyroxine levels in hyperthyroid or euthyroid patients | Serum Levels of Follistatin Are Positively Associated With Serum-Free Thyroxine Levels in Patients With Hyperthyroidism or Euthyroidism.
Tseng FY, Chen YT, Chi YC, Chen PL, Yang WS., Free PMC Article | 06/28/2016 |
| We report here an original observation that activin-B is upregulated in the human idiopathic pulmonary fibrosis lung. | Upregulation of activin-B and follistatin in pulmonary fibrosis - a translational study using human biopsies and a specific inhibitor in mouse fibrosis models.
Myllärniemi M, Tikkanen J, Hulmi JJ, Pasternack A, Sutinen E, Rönty M, Leppäranta O, Ma H, Ritvos O, Koli K., Free PMC Article | 05/21/2016 |
| changes in Follistatin levels during pregnancy contribute to the control of the activin A system | Longitudinal analysis of maternal serum Follistatin concentration in normal pregnancy and preeclampsia.
Garcés MF, Vallejo SA, Sanchez E, Palomino-Palomino MA, Leal LG, Ángel-Muller E, Díaz-Cruz LA, Ruíz-Parra AI, González-Clavijo AM, Castaño JP, Abba M, Lacunza E, Diéguez C, Nogueiras R, Caminos JE. | 05/14/2016 |
| Two angiogenic factors, follistatin (and HGF) are associated with prognosis in esophageal cancer patients. | Association of angiogenic factors with prognosis in esophageal cancer.
Dreikhausen L, Blank S, Sisic L, Heger U, Weichert W, Jäger D, Bruckner T, Giese N, Grenacher L, Falk C, Ott K, Schmidt T., Free PMC Article | 01/23/2016 |
| Adenomyotic tissues express high levels of myostatin, follistatin, and activin type II receptors. | Myostatin, follistatin and activin type II receptors are highly expressed in adenomyosis.
Carrarelli P, Yen CF, Arcuri F, Funghi L, Tosti C, Wang TH, Huang JS, Petraglia F. | 11/28/2015 |
| an imbalance between activin-A and follistatin contributes to the pathogenesis of cigarette smoke-induced inflammation and COPD | Role of activin-A in cigarette smoke-induced inflammation and COPD.
Verhamme FM, Bracke KR, Amatngalim GD, Verleden GM, Van Pottelberge GR, Hiemstra PS, Joos GF, Brusselle GG. | 01/31/2015 |
| Circulating follistatin levels are reduced in gestational diabetes mellitus and are positively associated with fetal growth and neonatal adiposity. | Serum activin A and follistatin levels in gestational diabetes and the association of the Activin A-Follistatin system with anthropometric parameters in offspring.
Näf S, Escote X, Ballesteros M, Yañez RE, Simón-Muela I, Gil P, Albaiges G, Vendrell J, Megia A., Free PMC Article | 01/24/2015 |
| higher than normal serum values common in H1N1 infection but found no association with the severity of respiratory failure | Serum activin A and B, and follistatin in critically ill patients with influenza A(H1N1) infection.
Linko R, Hedger MP, Pettilä V, Ruokonen E, Ala-Kokko T, Ludlow H, de Kretser DM., Free PMC Article | 01/3/2015 |
| data strongly support that up-regulation of FST in chondrocytes by skeletal dysplasia-inducing TRPV4 mutations contributes to disease pathogenesis. | Follistatin in chondrocytes: the link between TRPV4 channelopathies and skeletal malformations.
Leddy HA, McNulty AL, Lee SH, Rothfusz NE, Gloss B, Kirby ML, Hutson MR, Cohn DH, Guilak F, Liedtke W., Free PMC Article | 10/11/2014 |
| Follistatin, by its ability to neutralize the actions of activin A may be of value as an antifibrotic for radiation induced fibrosis. | Follistatin is induced by ionizing radiation and potentially predictive of radiosensitivity in radiation-induced fibrosis patient derived fibroblasts.
Forrester HB, Ivashkevich A, McKay MJ, Leong T, de Kretser DM, Sprung CN., Free PMC Article | 08/9/2014 |
| ERRbeta signalling leads to BCAS2-mediated blockage of the G1/S transition and inhibition of the epithelial to mesenchymal transition through FST-mediated regulation of E-cadherin | ERRβ signalling through FST and BCAS2 inhibits cellular proliferation in breast cancer cells.
Sengupta D, Bhargava DK, Dixit A, Sahoo BS, Biswas S, Biswas G, Mishra SK., Free PMC Article | 06/7/2014 |
| Plasma follistatin is moderately elevated in patients with type 2 diabetes. | Plasma follistatin is elevated in patients with type 2 diabetes: relationship to hyperglycemia, hyperinsulinemia, and systemic low-grade inflammation.
Hansen J, Rinnov A, Krogh-Madsen R, Fischer CP, Andreasen AS, Berg RM, Møller K, Pedersen BK, Plomgaard P. | 04/5/2014 |
| It is considered to have a significant role during tumor progression by influencing angiogenesis and metastasis. Thus, it serum level is a good tumor marker for hepatocellular carcinoma. | Prognotic impact of serum follistatin in patients with hepatocellular carcinoma.
Tomoda T, Nouso K, Miyahara K, Kobayashi S, Kinugasa H, Toyosawa J, Hagihara H, Kuwaki K, Onishi H, Nakamura S, Ikeda F, Miyake Y, Shiraha H, Takaki A, Yamamoto K. | 03/29/2014 |
| These results suggest that FOXL2 may act as a tumor suppressor in human adult-type GCTs by inducing follistatin expression, which subsequently inhibits activin-stimulated cell proliferation. | FOXL2-induced follistatin attenuates activin A-stimulated cell proliferation in human granulosa cell tumors.
Cheng JC, Chang HM, Qiu X, Fang L, Leung PC. | 03/15/2014 |