| Kindlin-2 is mainly expressed in the cytoplasm and nuclei of fibroblasts in the Esophageal cancer (EC) stroma. Kindlin-2 is upregulated in ECs compared with normal esophageal tissues. Kindlin-2 is more prevalent in poorly differentiated tumors. Kindlin-2 is expressed higher in EC smoker patients than non-smoker patients. Patients with a family history of EC show lower Kindlin-2 expression. | Differential expression of Kindlin-1 and Kindlin-2 correlates with esophageal cancer progression and epidemiology.
Wang P, Zhan J, Song J, Wang Y, Fang W, Liu Z, Zhang H. | 07/14/2018 |
| Long noncoding RNA-ATB functions as a molecular sponge for miR-200b and Kindlin-2. | Long non-coding RNA ATB promotes malignancy of esophageal squamous cell carcinoma by regulating miR-200b/Kindlin-2 axis.
Li Z, Wu X, Gu L, Shen Q, Luo W, Deng C, Zhou Q, Chen X, Li Y, Lim Z, Wang X, Wang J, Yang X., Free PMC Article | 03/31/2018 |
| Kindlin-2 is up-regulated in glioma cells and acts as an oncogene. It is an independent risk factor for poor prognosis. The Kindlin-2/YB-1/beta-catenin complex promotes EGFR transcription and contributes to glioma progression. Kindlin-2 is a potential diagnostic and prognostic marker in glioma, and inhibition of Kindlin-2 may be a novel strategy for glioma treatment. | Kindlin-2 interacts with β-catenin and YB-1 to enhance EGFR transcription during glioma progression.
Ou Y, Zhao Z, Zhang W, Wu Q, Wu C, Liu X, Fu M, Ji N, Wang D, Qiu J, Zhang L, Yu C, Song Y, Zhan Q., Free PMC Article | 03/3/2018 |
| the rs17125944 polymorphism in FERMT2 gene might not be association with late-onset Alzheimer's disease in northern Han Chinese population | FERMT2 rs17125944 polymorphism with Alzheimer's disease risk: a replication and meta-analysis.
Zhang QY, Wang HF, Zheng ZJ, Kong LL, Tan MS, Tan CC, Zhang W, Wang ZX, Tan L, Yu JT, Tan L., Free PMC Article | 01/27/2018 |
| analysis of the Kindlin-2-RhoGDIalpha-Rac1 signaling axis that is critical for regulation of podocyte structure and function in vivo | Kindlin-2 Association with Rho GDP-Dissociation Inhibitor α Suppresses Rac1 Activation and Podocyte Injury.
Sun Y, Guo C, Ma P, Lai Y, Yang F, Cai J, Cheng Z, Zhang K, Liu Z, Tian Y, Sheng Y, Tian R, Deng Y, Xiao G, Wu C., Free PMC Article | 12/30/2017 |
| Study found that FERMT2 (a beta3-integrin co-activator) was significantly associated with a variation in cerebrospinal fluid Abeta peptide levels in 2886 Alzheimer's disease cases.Under-expression of FERMT2 increases Abeta peptide production by raising levels of mature APP at the cell surface and facilitating its recycling | Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism.
Chapuis J, Flaig A, Grenier-Boley B, Eysert F, Pottiez V, Deloison G, Vandeputte A, Ayral AM, Mendes T, Desai S, Goate AM, Kauwe JSK, Leroux F, Herledan A, Demiautte F, Bauer C, Checler F, Petersen RC, Blennow K, Zetterberg H, Minthon L, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Albert M, Moghekar A, O'Brien R, Peskind ER, Malmanche N, Schellenberg GD, Dourlen P, Song OR, Cruchaga C, Amouyel P, Deprez B, Brodin P, Lambert JC, ADGC, Alzheimer’s Disease Neuroimaging Initiative., Free PMC Article | 12/9/2017 |
| High kindlin 2 expression is associated with Breast Cancer. | Kindlin-2 Regulates the Growth of Breast Cancer Tumors by Activating CSF-1-Mediated Macrophage Infiltration.
Sossey-Alaoui K, Pluskota E, Bialkowska K, Szpak D, Parker Y, Morrison CD, Lindner DJ, Schiemann WP, Plow EF., Free PMC Article | 11/4/2017 |
| Data suggest that the extreme C terminus of kindlin-2 is essential for interaction with and activation of integrin alphaIIBbeta3; these studies were conducted in macrophage cell line and erythroleukemia cell line. | The extreme C-terminal region of kindlin-2 is critical to its regulation of integrin activation.
Hirbawi J, Bialkowska K, Bledzka KM, Liu J, Fukuda K, Qin J, Plow EF., Free PMC Article | 09/16/2017 |
| We show a direct relationship between kindlin-1 abundance and UV-B induced apoptosis in keratinocytes, whereas kindlin-2 overexpression has no compensatory effect. | UV-B-induced cutaneous inflammation and prospects for antioxidant treatment in Kindler syndrome.
Maier K, He Y, Wölfle U, Esser PR, Brummer T, Schempp C, Bruckner-Tuderman L, Has C. | 06/10/2017 |
| The F0 domain of K2 binds actin. | Kindlin-2 directly binds actin and regulates integrin outside-in signaling.
Bledzka K, Bialkowska K, Sossey-Alaoui K, Vaynberg J, Pluskota E, Qin J, Plow EF., Free PMC Article | 08/27/2016 |
| data indicate that kindlin-2 promotes the invasiveness of prostate cancer cells largely through NF-kappaB-dependent upregulation of MMP-9 and MMP-2 | Kindlin-2 promotes invasiveness of prostate cancer cells via NF-κB-dependent upregulation of matrix metalloproteinases.
Yang JR, Pan TJ, Yang H, Wang T, Liu W, Liu B, Qian WH. | 06/4/2016 |
| High kindlin-2 expression is associated with esophageal squamous cell carcinoma. | A three-protein signature and clinical outcome in esophageal squamous cell carcinoma.
Cao HH, Zhang SY, Shen JH, Wu ZY, Wu JY, Wang SH, Li EM, Xu LY., Free PMC Article | 01/23/2016 |
| our findings suggested that Kindlin-2 was highly expressed in hepatocellular carcinoma tissues and was closely related to clinical progression. Kindlin-2 protein could be a potential biomarker for predicting poor prognosis of HCC patients after surgery. | Kindlin-2: a novel prognostic biomarker for patients with hepatocellular carcinoma.
Ge YS, Liu D, Jia WD, Li JS, Ma JL, Yu JH, Xu GL. | 12/12/2015 |
| findings suggest that Src, Kindlin-2 and Migfilin together constitute a positive feedback loop that controls Src activity and regulates integrin-mediated cellular func | Kindlin-2 phosphorylation by Src at Y193 enhances Src activity and is involved in Migfilin recruitment to the focal adhesions.
Liu Z, Lu D, Wang X, Wan J, Liu C, Zhang H. | 10/3/2015 |
| Data indicate that Kindlin-2 mRNA levels in adult is highly expressed in mesoderm-derived organs. | Kindlin-2 expression in adult tissues correlates with their embryonic origins.
Zhan J, Yang M, Chi X, Zhang J, Pei X, Ren C, Guo Y, Liu W, Zhang H. | 04/25/2015 |
| A major ILK binding site in the kindlin-2 FERM domain for regulating cell adhesion has been mapped. | Molecular basis of kindlin-2 binding to integrin-linked kinase pseudokinase for regulating cell adhesion.
Fukuda K, Bledzka K, Yang J, Perera HD, Plow EF, Qin J., Free PMC Article | 02/7/2015 |
| the first evidence that interaction between the integrin beta1 cytoplasmic tail and kindlin-2, a member of a family of adapters implicated in human disease pathogenesis, is mainly governed by the beta1 C-terminal carboxylate moiety | C-terminal COOH of integrin β1 is necessary for β1 association with the kindlin-2 adapter protein.
Fitzpatrick P, Shattil SJ, Ablooglu AJ., Free PMC Article | 06/7/2014 |
| Kindlin-2 was highly expressed in the peritumoral stroma of pancreatic ductal adenocarcinomas. Stromal kindlin-2 expression was related to nodal metastasis (P = 0.03). | Kindlin-2 expression in peritumoral stroma is associated with poor prognosis in pancreatic ductal adenocarcinoma.
Mahawithitwong P, Ohuchida K, Ikenaga N, Fujita H, Zhao M, Kozono S, Shindo K, Ohtsuka T, Mizumoto K, Tanaka M. | 12/14/2013 |
| Kindlin-2 mediates activation of TGF-beta/Smad signaling and renal fibrosis. | Kindlin-2 mediates activation of TGF-β/Smad signaling and renal fibrosis.
Wei X, Xia Y, Li F, Tang Y, Nie J, Liu Y, Zhou Z, Zhang H, Hou FF., Free PMC Article | 11/2/2013 |
| Kindlin-2 might promote the invasion of gastric cancer cells through enhancing proliferation and adhesion by the phosphorylation of integrin beta1 and beta3. | Novel focal adhesion protein kindlin-2 promotes the invasion of gastric cancer cells through phosphorylation of integrin β1 and β3.
Shen Z, Ye Y, Kauttu T, Seppänen H, Vainionpää S, Wang S, Mustonen H, Puolakkainen P. | 09/21/2013 |
| Kindlin 2 plays a novel role in epigenetic repression of miR-200 family, a mechanism that promotes breast cancer invasion. | Kindlin 2 promotes breast cancer invasion via epigenetic silencing of the microRNA200 gene family.
Yu Y, Wu J, Guan L, Qi L, Tang Y, Ma B, Zhan J, Wang Y, Fang W, Zhang H. | 09/14/2013 |
| Kindlin-1 and Kindlin-2 have opposite roles in lung cancers | Opposite role of Kindlin-1 and Kindlin-2 in lung cancers.
Zhan J, Zhu X, Guo Y, Wang Y, Wang Y, Qiang G, Niu M, Hu J, Du J, Li Z, Cui J, Ma B, Fang W, Zhang H., Free PMC Article | 06/29/2013 |
| the novel focal adhesion gene kindlin-2 may play an important role in promoting the invasion of gastric cancer cells mediated by tumor-associated macrophages through regulating interleukin expression. | The novel focal adhesion gene kindlin-2 promotes the invasion of gastric cancer cells mediated by tumor-associated macrophages.
Shen Z, Ye Y, Kauttu T, Seppänen H, Vainionpää S, Wang S, Mustonen H, Puolakkainen P. | 06/15/2013 |
| A novel regulatory loop has been described between GLI1 and Kindlin-2 that determines cancer cell viability. | A feedback regulation between Kindlin-2 and GLI1 in prostate cancer cells.
Gao J, Khan AA, Shimokawa T, Zhan J, Strömblad S, Fang W, Zhang H. | 05/4/2013 |
| Kindlin-2 regulates breast cancer progression by inducing genome instability. | Kindlin-2 promotes genome instability in breast cancer cells.
Zhao T, Guan L, Yu Y, Pei X, Zhan J, Han L, Tang Y, Li F, Fang W, Zhang H. | 04/6/2013 |