| CRY-1 was expressed in 94% of the CLL patients at diagnosis. The median CRY-1 relative gene expression level (0.006) stratified patients into high and low expression groups. Forty of 100 (40%) CLL patients showed high CRY-1, 54/100 (54%) showed low CRY-1, and 6/100 (6%) had undetectable CRY-1 gene expression. | Cryptochrome-1 Gene Expression is a Reliable Prognostic Indicator in Egyptian Patients with Chronic Lymphocytic Leukemia: A Prospective Cohort Study.
Habashy DM, Eissa DS, Aboelez MM., Free PMC Article | 11/3/2018 |
| Independent silencing of CRY1 and CRY2 genes in HAC15 cells resulted in a mild upregulation of HSD3B2 without affecting HSD3B1 expression. In conclusion, our results support the hypothesis that CRY1 and CRY2, being AngII-regulated genes, and showing a differential expression in APAs when compared with the adjacent adrenal cortex, might be involved in adrenal cell function, and in the regulation of aldosterone production | Role of Cryptochrome-1 and Cryptochrome-2 in Aldosterone-Producing Adenomas and Adrenocortical Cells.
Tetti M, Castellano I, Venziano F, Magnino C, Veglio F, Mulatero P, Monticone S., Free PMC Article | 10/20/2018 |
| The studies in this review reported contrasting results about the association of different single nucleotide polymorphisms (SNPs) in clock genes and Major Depressive Disorder. The most consistent result reported the association between SNP rs2287161 of CRY1 and MDD development. | The role of clock genes in the etiology of Major Depressive Disorder: Special Section on "Translational and Neuroscience Studies in Affective Disorders". Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summaries relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders.
Buoli M, Serati M, Grassi S, Pergoli L, Cantone L, Altamura AC, Bollati V. | 08/18/2018 |
| CRY1/2 serve as corepressors for many NRs. | Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity.
Kriebs A, Jordan SD, Soto E, Henriksson E, Sandate CR, Vaughan ME, Chan AB, Duglan D, Papp SJ, Huber AL, Afetian ME, Yu RT, Zhao X, Downes M, Evans RM, Lamia KA., Free PMC Article | 05/19/2018 |
| Study confirms the prognostic role of CRY1 in chronic lymphocytic leukemia, as its aberrant methylation and expression is associated with high risk of treatment initiation and survival. | Genome-wide DNA methylation profiling integrated with gene expression profiling identifies PAX9 as a novel prognostic marker in chronic lymphocytic leukemia.
Rani L, Mathur N, Gupta R, Gogia A, Kaur G, Dhanjal JK, Sundar D, Kumar L, Sharma A., Free PMC Article | 03/17/2018 |
| CRY1 SNP rs714359 showed nominally significant association with the problematicity of seasonal variations (problematic vs. no variation) of mood disorder. The set-based analysis did not support these associations. However, the CRY1 haplotype TAG including rs714359 showed nominally significant association with the problematicity of seasonal variations in mood disorder. | CRY1 and CRY2 genetic variants in seasonality: A longitudinal and cross-sectional study.
Kovanen L, Donner K, Kaunisto M, Partonen T. | 11/18/2017 |
| CRY1 variants were not associated with major depressive disorder. | PRKCDBP (CAVIN3) and CRY2 associate with major depressive disorder.
Kovanen L, Donner K, Kaunisto M, Partonen T. | 11/18/2017 |
| Our findings suggest that CLOCK and CRY1 polymorphisms might be involved in individual susceptibility to abdominal obesity in Chinese Han population. | Associations of polymorphisms in circadian genes with abdominal obesity in Chinese adult population.
Ye D, Cai S, Jiang X, Ding Y, Chen K, Fan C, Jin M. | 11/4/2017 |
| Knockout-rescue embryonic stem cell-derived mouse reveals that CRY1 determines circadian period through both its degradation-dependent and -independent pathways. | Knockout-Rescue Embryonic Stem Cell-Derived Mouse Reveals Circadian-Period Control by Quality and Quantity of CRY1.
Ode KL, Ukai H, Susaki EA, Narumi R, Matsumoto K, Hara J, Koide N, Abe T, Kanemaki MT, Kiyonari H, Ueda HR. | 10/7/2017 |
| The present study identified USP7 and TDP-43 as the regulators of CRY1 and CRY2, underscoring the significance of the stability control process of CRY proteins for period determination in the mammalian circadian clockwork. | USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock.
Hirano A, Nakagawa T, Yoshitane H, Oyama M, Kozuka-Hata H, Lanjakornsiripan D, Fukada Y., Free PMC Article | 03/18/2017 |
| Altered CRY1 and CRY2 expression patterns and the interplay with the genetic landscape in colon cancer cells may underlie phenotypic divergence. | Deregulated expression of cryptochrome genes in human colorectal cancer.
Mazzoccoli G, Colangelo T, Panza A, Rubino R, De Cata A, Tiberio C, Valvano MR, Pazienza V, Merla G, Augello B, Trombetta D, Storlazzi CT, Macchia G, Gentile A, Tavano F, Vinciguerra M, Bisceglia G, Rosato V, Colantuoni V, Sabatino L, Piepoli A., Free PMC Article | 10/1/2016 |
| possible circadian rhythm in full-term placental expression | Evidence for clock genes circadian rhythms in human full-term placenta.
Pérez S, Murias L, Fernández-Plaza C, Díaz I, González C, Otero J, Díaz E. | 09/17/2016 |
| Given the distinct characteristics of the C-terminal tails of the CRY1 and CRY2 proteins, our study addresses a long-standing hypothesis that the ratio of these two CRY molecules affects the clock period. | The ratio of intracellular CRY proteins determines the clock period length.
Li Y, Xiong W, Zhang EE. | 08/13/2016 |
| Overexpression of CRY1 protects against the development of atherosclerosis via the TLR/NFkappaB pathway | Overexpression of CRY1 protects against the development of atherosclerosis via the TLR/NF-κB pathway.
Yang L, Chu Y, Wang L, Wang Y, Zhao X, He W, Zhang P, Yang X, Liu X, Tian L, Li B, Dong S, Gao C. | 07/30/2016 |
| Collectively, these data show that KPNB1 is required for timely nuclear import of PER/CRY in the negative feedback regulation of the circadian clock. | KPNB1 mediates PER/CRY nuclear translocation and circadian clock function.
Lee Y, Jang AR, Francey LJ, Sehgal A, Hogenesch JB., Free PMC Article | 07/2/2016 |
| these observations suggest a biologically plausible season-dependent association between SNPs at CRY1, CRY2 and MTNR1B and glucose homeostasis. | Season-dependent associations of circadian rhythm-regulating loci (CRY1, CRY2 and MTNR1B) and glucose homeostasis: the GLACIER Study.
Renström F, Koivula RW, Varga TV, Hallmans G, Mulder H, Florez JC, Hu FB, Franks PW. | 01/23/2016 |
| CRY1 and CRY2 variants showed nominal association with the metabolic syndrome components, hypertension and triglyceride levels. | CRY1, CRY2 and PRKCDBP genetic variants in metabolic syndrome.
Kovanen L, Donner K, Kaunisto M, Partonen T. | 11/28/2015 |
| In men undergoing acute total sleep deprivation, there was increased methylation in the promoter of CRY1 in adipose tissue compared with controls. Also decreased gene expression in skeletal muscle. | Acute Sleep Loss Induces Tissue-Specific Epigenetic and Transcriptional Alterations to Circadian Clock Genes in Men.
Cedernaes J, Osler ME, Voisin S, Broman JE, Vogel H, Dickson SL, Zierath JR, Schiöth HB, Benedict C. | 11/28/2015 |
| SNPs in CRY1 were significantly associated with overall survival in Chinese hepatocellular carcinoma patients. | Functional polymorphisms of circadian negative feedback regulation genes are associated with clinical outcome in hepatocellular carcinoma patients receiving radical resection.
Zhang Z, Ma F, Zhou F, Chen Y, Wang X, Zhang H, Zhu Y, Bi J, Zhang Y. | 06/27/2015 |
| Study reveals an interaction between a CRY1 variant and carbohydrate intake for glucose metabolism. | CRY1 circadian gene variant interacts with carbohydrate intake for insulin resistance in two independent populations: Mediterranean and North American.
Dashti HS, Smith CE, Lee YC, Parnell LD, Lai CQ, Arnett DK, Ordovás JM, Garaulet M., Free PMC Article | 01/31/2015 |
| findings show the polymorphisms of Cry1 rs2287161 and Tef rs738499 are associated to major depressive disorder in the Chinese population | Cry1 and Tef gene polymorphisms are associated with major depressive disorder in the Chinese population.
Hua P, Liu W, Chen D, Zhao Y, Chen L, Zhang N, Wang C, Guo S, Wang L, Xiao H, Kuo SH., Free PMC Article | 06/28/2014 |
| Casein kinase 1 primarily regulates the accumulating phase of the PER-CRY repressive complex by controlling the nuclear import rate. | Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock.
St John PC, Hirota T, Kay SA, Doyle FJ 3rd., Free PMC Article | 04/5/2014 |
| data suggest a new role for the C-terminal tail of CRY1 in which phosphorylation rhythmically regulates CRY1 stability and contributes to the proper circadian period length | Phosphorylation of the cryptochrome 1 C-terminal tail regulates circadian period length.
Gao P, Yoo SH, Lee KJ, Rosensweig C, Takahashi JS, Chen BP, Green CB., Free PMC Article | 02/15/2014 |
| Cry1 likely plays important roles in colorectal cancer development and progression. | Cryptochrome 1 overexpression correlates with tumor progression and poor prognosis in patients with colorectal cancer.
Yu H, Meng X, Wu J, Pan C, Ying X, Zhou Y, Liu R, Huang W., Free PMC Article | 11/30/2013 |
| Data suggest that clock genes Per1, Cry1, Clock, and Bmal1 and their protein products may be directly involved in the daytime-dependent regulation and adaptation of hormone synthesis. | Clock gene expression in the human pituitary gland.
Wunderer F, Kühne S, Jilg A, Ackermann K, Sebesteny T, Maronde E, Stehle JH. | 07/27/2013 |