| A pathological role for E2F2 was identified in rheumatoid arthritis synovial fibroblasts. | E2F2 directly regulates the STAT1 and PI3K/AKT/NF-κB pathways to exacerbate the inflammatory phenotype in rheumatoid arthritis synovial fibroblasts and mouse embryonic fibroblasts.
Wang S, Wang L, Wu C, Sun S, Pan JH., Free PMC Article | 07/20/2019 |
| p16INK4a promoted cartilage injury by increasing the expression of E2F2 in chondrocytes. | Up-regulated expression of E2F2 is necessary for p16INK4a-induced cartilage injury.
Bao X, Hu X., Free PMC Article | 01/12/2019 |
| miR-214 overexpression inhibits glioma cell growth in vitro and in vivo by inducing cell cycle arrest in G0/G1. Collectively, these data uncover a novel role for a PPARalpha-miR-214-E2F2 pathway in controlling glioma cell proliferation. | PPARα Regulates the Proliferation of Human Glioma Cells through miR-214 and E2F2.
Gao Y, Han D, Sun L, Huang Q, Gai G, Wu Z, Meng W, Chen X., Free PMC Article | 10/6/2018 |
| miR-99a reveals two novel targets E2F2 and EMR2 that play a key role in lung tumourigenesis. By inhibiting E2F2 and EMR2, miR-99a represses in vivo the transition of epithelial cells through an EMT process concomitantly with the inhibition of stemness features and consequently decreasing the CSC population. | miR-99a reveals two novel oncogenic proteins E2F2 and EMR2 and represses stemness in lung cancer.
Feliciano A, Garcia-Mayea Y, Jubierre L, Mir C, Hummel M, Castellvi J, Hernández-Losa J, Paciucci R, Sansano I, Sun Y, Ramón Y Cajal S, Kondon H, Soriano A, Segura M, Lyakhovich A, LLeonart ME., Free PMC Article | 07/7/2018 |
| Low E2F2 expression is associated with invasion in clear cell renal cell carcinoma. | miR-155 regulates the proliferation and invasion of clear cell renal cell carcinoma cells by targeting E2F2.
Gao Y, Ma X, Yao Y, Li H, Fan Y, Zhang Y, Zhao C, Wang L, Ma M, Lei Z, Zhang X., Free PMC Article | 01/27/2018 |
| Data indicate E2F transcription factor 2 protein (E2F2) as the direct target of miR-31 in gastric cancer cells. | Downregulated miR-31 level associates with poor prognosis of gastric cancer and its restoration suppresses tumor cell malignant phenotypes by inhibiting E2F2.
Wang H, Zhang X, Liu Y, Ni Z, Lin Y, Duan Z, Shi Y, Wang G, Li F., Free PMC Article | 12/30/2017 |
| Using iterative experimental and computational analyses, the authors show physical and functional interactions between NF-kappaB and the E2 Factor 1 (E2F-1) and E2 Factor 4 (E2F-4) cell cycle regulators. | Dynamic NF-κB and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation.
Ankers JM, Awais R, Jones NA, Boyd J, Ryan S, Adamson AD, Harper CV, Bridge L, Spiller DG, Jackson DA, Paszek P, Sée V, White MR., Free PMC Article | 11/18/2017 |
| These results suggest that miR-125a acts as a tumor suppressor via regulation of E2F2 expression in osteosarcoma progression, and miR-125a may represent a novel therapeutic target for the treatment of osteosarcoma. | MicroRNA-125a Regulates Cell Proliferation Via Directly Targeting E2F2 in Osteosarcoma.
Tao T, Shen Q, Luo J, Xu Y, Liang W. | 11/4/2017 |
| Accordingly, our results demonstrated that NAMPT is a prognostic marker in melanoma, and the identificationofNAMPT-E2F2-SIRT1 pathway establishes another link between NAMPT and apoptosis events in melanoma, with therapeutic implications for this deadly cancer. | The NAMPT/E2F2/SIRT1 axis promotes proliferation and inhibits p53-dependent apoptosis in human melanoma cells.
Zhao H, Tang W, Chen X, Wang S, Wang X, Xu H, Li L. | 10/28/2017 |
| Compared with patients with variant genotypes of E2F2-rs2742976 and E2F2-rs3218123, patients with common homozygous genotypes had better disease-free survival (both log-rank, P < 0.001) and lower squamous cell carcinoma of the oropharynx recurrence risk (HR, 0.4, 95% CI, 0.3-0.6 and HR, 0.3, 95% CI, 0.2-0.5, respectively) after multivariable adjustment. | E2F transcription factor 2 variants as predictive biomarkers for recurrence risk in patients with squamous cell carcinoma of the oropharynx.
Li Y, Sturgis EM, Zhu L, Cao X, Wei Q, Zhang H, Li G., Free PMC Article | 09/16/2017 |
| Let-7b inhibits the malignant behavior of glioma cells and glioma stem-like cells via downregulation of E2F2. | Let-7b inhibits the malignant behavior of glioma cells and glioma stem-like cells via downregulation of E2F2.
Song H, Zhang Y, Liu N, Zhang D, Wan C, Zhao S, Kong Y, Yuan L. | 03/11/2017 |
| In NSCLC patients, E2F2 expression was found to be significantly correlated with sex and tumor size. E2F1 and E2F2 overexpression showed a significant association with poor prognosis. | Expression and prognostic value of E2F activators in NSCLC and subtypes: a research based on bioinformatics analysis.
Gao Z, Shi R, Yuan K, Wang Y. | 03/4/2017 |
| Data indicate that microRNA miR-214 has tumor-suppressive activity in hepatocellular carcinoma (HCC) through inhibition of E2F2 transcription factor (E2F2), cyclin-dependent kinases CDK3 and CDK6. | miR-214/199a/199a* cluster levels predict poor survival in hepatocellular carcinoma through interference with cell-cycle regulators.
Wang P, Chen S, Fang H, Wu X, Chen D, Peng L, Gao Z, Xie C., Free PMC Article | 11/12/2016 |
| we validated for the first time that E2F2 acts as a tumor activator in non-small cell lung carcinoma. | E2F2 induction in related to cell proliferation and poor prognosis in non-small cell lung carcinoma.
Chen L, Yu JH, Lu ZH, Zhang W., Free PMC Article | 10/1/2016 |
| E2F2 loss results in increased lung metastasis in breast cancer, potentially functioning through a PTPRD dependent mechanism. | Increased metastasis with loss of E2F2 in Myc-driven tumors.
Yuwanita I, Barnes D, Monterey MD, O'Reilly S, Andrechek ER., Free PMC Article | 09/10/2016 |
| Elevated E2F2 expression in glioblastoma cells weakens the effect of elevated levels of miR-218. | MiR-218 Inhibited Growth and Metabolism of Human Glioblastoma Cells by Directly Targeting E2F2.
Zhang Y, Han D, Wei W, Cao W, Zhang R, Dong Q, Zhang J, Wang Y, Liu N. | 07/30/2016 |
| cell cycle-dependent transcription of the TRAIP gene by E2F1, E2F2, and E2F4 and rapid protein degradation leads to cell cycle-dependent expression with a maximum in G2/M | The TRAF-interacting protein (TRAIP) is a novel E2F target with peak expression in mitosis.
Chapard C, Hohl D, Huber M., Free PMC Article | 06/28/2016 |
| miR218 and miR520a are crucial in the development of hepatocellular carcinoma via the inhibition of cell proliferation and cycle progression by downregulating E2F2. | MicroRNA-218 and microRNA-520a inhibit cell proliferation by downregulating E2F2 in hepatocellular carcinoma.
Dong Y, Zou J, Su S, Huang H, Deng Y, Wang B, Li W., Free PMC Article | 01/2/2016 |
| miR-31 regulated the proliferation of colon cancer cells by targeting E2F2. | miR-31 promotes proliferation of colon cancer cells by targeting E2F2.
Li T, Luo W, Liu K, Lv X, Xi T. | 12/19/2015 |
| Results show evidence that let-7a expression in osteosarcoma (OS) cells is significantly reduced and inversely correlated with E2F2 expression levels and that let-7a plays an important role in OS cell proliferation and tumorigenesis by targeting E2F2. | Tumor-suppressive microRNA-let-7a inhibits cell proliferation via targeting of E2F2 in osteosarcoma cells.
Iwasaki T, Tanaka K, Kawano M, Itonaga I, Tsumura H. | 12/12/2015 |
| Overall, miR-155 plays an important role in colorectal carcinoma tumorigenesis by negative regulation of its targets including E2F2. | miR-155 regulates the proliferation and cell cycle of colorectal carcinoma cells by targeting E2F2.
Li T, Yang J, Lv X, Liu K, Gao C, Xing Y, Xi T. | 04/4/2015 |
| Low expression of E2F2 may reflect functional redundancy between members of the E2F family, in this case between E2F1 and E2F2. | The relationship between E2F family members and tumor growth in colorectal adenocarcinomas: A comparative immunohistochemical study of 100 cases.
Xanthoulis A, Kotsinas A, Tiniakos D, Fiska A, Tentes AA, Kyroudi A, Kittas C, Gorgoulis V. | 03/21/2015 |
| these results indicate that LXR ligands target gene networks, including those regulated by E2F family members, are critical for tumor biology and disease progression and merit further consideration as potential agents | Liver × receptor ligands disrupt breast cancer cell proliferation through an E2F-mediated mechanism.
Nguyen-Vu T, Vedin LL, Liu K, Jonsson P, Lin JZ, Candelaria NR, Candelaria LP, Addanki S, Williams C, Gustafsson JÅ, Steffensen KR, Lin CY., Free PMC Article | 03/21/2015 |
| E2F2 knockdown can inhibit hESC proliferation and tumorigenicity without significantly harming stemness. | Knockdown of E2F2 inhibits tumorigenicity, but preserves stemness of human embryonic stem cells.
Suzuki DE, Nakahata AM, Okamoto OK. | 01/17/2015 |
| Data suggest that the uniquely increased expression of CD38 and E2F2 in rheumatoid arthritis (RA) synovial tissues contribute to the immunoactivation of the disease. | CD38 and E2F transcription factor 2 have uniquely increased expression in rheumatoid arthritis synovial tissues.
Chang X, Yue L, Liu W, Wang Y, Wang L, Xu B, Wang Y, Pan J, Yan X., Free PMC Article | 06/21/2014 |