| Promoter hypermethylation of SFRP3 is a common event hepatocellular carcinoma. | Promoter methylation of SFRP3 is frequent in hepatocellular carcinoma.
Lin YW, Shih YL, Lien GS, Suk FM, Hsieh CB, Yan MD., Free PMC Article | 01/24/2015 |
| FRZB knockdown may upregulate the Wnt/betacatenin pathway and promote aggressiveness in gastric cancer. | FRZB knockdown upregulates β-catenin activity and enhances cell aggressiveness in gastric cancer.
Qin S, Zhang Z, Li J, Zang L. | 01/17/2015 |
| The compound heterozygosity for mutations in the MFRP gene described in the present study should severely affect the function of MFRP by completely removing the cubilin, LDL-A and frizzled-related CRD domains. | Novel membrane frizzled-related protein gene mutation as cause of posterior microphthalmia resulting in high hyperopia with macular folds.
Wasmann RA, Wassink-Ruiter JS, Sundin OH, Morales E, Verheij JB, Pott JW., Free PMC Article | 12/20/2014 |
| Data indicate an inverse correlation between osteoarthritis and GREM1, FRZB and DKK1 gene expression. | GREM1, FRZB and DKK1 mRNA levels correlate with osteoarthritis and are regulated by osteoarthritis-associated factors.
Leijten JC, Bos SD, Landman EB, Georgi N, Jahr H, Meulenbelt I, Post JN, van Blitterswijk CA, Karperien M., Free PMC Article | 08/9/2014 |
| There is an association between increased sFRP3 expression and adverse outcome in heart failure. | The cardiokine secreted Frizzled-related protein 3, a modulator of Wnt signalling, in clinical and experimental heart failure.
Askevold ET, Aukrust P, Nymo SH, Lunde IG, Kaasbøll OJ, Aakhus S, Florholmen G, Ohm IK, Strand ME, Attramadal H, Fiane A, Dahl CP, Finsen AV, Vinge LE, Christensen G, Yndestad A, Gullestad L, Latini R, Masson S, Tavazzi L, GISSI-HF Investigators, Ueland T. | 07/26/2014 |
| Secreted frizzled-related protein 3 (sFRP3) regulates antidepressant responses in human. | Secreted frizzled-related protein 3 (sFRP3) regulates antidepressant responses in mice and humans.
Jang MH, Kitabatake Y, Kang E, Jun H, Pletnikov MV, Christian KM, Hen R, Lucae S, Binder EB, Song H, Ming GI., Free PMC Article | 03/29/2014 |
| Studied the expression of TCF/LEF and SFRP family members (SFRP1 and SFRP3) to gain a better understanding of biological signaling pathways responsible for epidemiology and clinical parameters of clear cell RCC (cRCC). | Expression of secreted frizzled-related protein 1 and 3, T-cell factor 1 and lymphoid enhancer factor 1 in clear cell renal cell carcinoma.
Nikuševa-Martić T, Serman L, Zeljko M, Vidas Z, Gašparov S, Zeljko HM, Kosović M, Pećina-Šlaus N. | 02/1/2014 |
| The rs7775 SNP in exon 6 of SFRP3 gene that codes for either arginine or glycine exhibited very strong association with breast cancer, even after Bonferroni's correction. | Association of single nucleotide polymorphisms in Wnt signaling pathway genes with breast cancer in Saudi patients.
Alanazi MS, Parine NR, Shaik JP, Alabdulkarim HA, Ajaj SA, Khan Z., Free PMC Article | 11/2/2013 |
| Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis. | Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis.
Baker-Lepain JC, Lynch JA, Parimi N, McCulloch CE, Nevitt MC, Corr M, Lane NE., Free PMC Article | 07/14/2012 |
| SFRP3 functions as a melanoma migration and invasion suppressor by interfering with Wnt5a signaling. | Methylation and loss of Secreted Frizzled-Related Protein 3 enhances melanoma cell migration and invasion.
Ekström EJ, Sherwood V, Andersson T., Free PMC Article | 08/20/2011 |
| Loss of WNT pathway inhibition due to SFRP3 gene silencing is associated with medulloblastoma. | The SFRP family of WNT inhibitors function as novel tumor suppressor genes epigenetically silenced in medulloblastoma.
Kongkham PN, Northcott PA, Croul SE, Smith CA, Taylor MD, Rutka JT. | 06/28/2010 |
| sFRP3 expression promotes cell growth, invasion, and inhibition of apoptosis in renal cancer cells. | Role of secreted frizzled-related protein 3 in human renal cell carcinoma.
Hirata H, Hinoda Y, Ueno K, Majid S, Saini S, Dahiya R. | 04/12/2010 |
| Meta-analysis and HuGE review of gene-disease association. (HuGE Navigator) | Field synopsis and synthesis of genetic association studies in osteoarthritis: the CUMAGAS-OSTEO information system.
Zintzaras E, Kitsios GD, Ziogas DC, Rodopoulou P, Karachalios T. | 04/7/2010 |
| The expression of FRZB in gastric cancer is correlated with tumor cell differentiation and tumor Lauren classification. | [Expression and intracellular localization of FRZB gene in gastric cancer and its significance].
Qu Y, Cai Q, Li JF, Wang YW, Liu BY, Zhu ZG. | 03/15/2010 |
| Our results suggest that natural variation in FRZB is not a major contributor to the observed variability in peak bone mineral density in either Chinese females or males | No association of the polymorphisms of the frizzled-related protein gene with peak bone mineral density in Chinese nuclear families.
Gao G, Zhang ZL, He JW, Zhang H, Yue H, Hu WW, Gu JM, Fu WZ, Hu YQ, Li M, Liu YJ, Yu JB, Gao G, Zhang ZL, He JW, Zhang H, Yue H, Hu WW, Gu JM, Fu WZ, Hu YQ, Li M, Liu YJ, Yu JB., Free PMC Articles: PMC2806249, PMC2806249 | 02/8/2010 |
| Findings do not support the notion that FRZB rs7775 or rs288326 have any sizable genetic effect on osteoarthritis phenotypes. | Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand.
Evangelou E, Chapman K, Meulenbelt I, Karassa FB, Loughlin J, Carr A, Doherty M, Doherty S, Gómez-Reino JJ, Gonzalez A, Halldorsson BV, Hauksson VB, Hofman A, Hart DJ, Ikegawa S, Ingvarsson T, Jiang Q, Jonsdottir I, Jonsson H, Kerkhof HJ, Kloppenburg M, Lane NE, Li J, Lories RJ, van Meurs JB, Näkki A, Nevitt MC, Rodriguez-Lopez J, Shi D, Slagboom PE, Stefansson K, Tsezou A, Wallis GA, Watson CM, Spector TD, Uitterlinden AG, Valdes AM, Ioannidis JP, Evangelou E, Chapman K, Meulenbelt I, Karassa FB, Loughlin J, Carr A, Doherty M, Doherty S, Gómez-Reino JJ, Gonzalez A, Halldorsson BV, Hauksson VB, Hofman A, Hart DJ, Ikegawa S, Ingvarsson T, Jiang Q, Jonsdottir I, Jonsson H, Kerkhof HJ, Kloppenburg M, Lane NE, Li J, Lories RJ, van Meurs JB, Näkki A, Nevitt MC, Rodriguez-Lopez J, Shi D, Slagboom PE, Stefansson K, Tsezou A, Wallis GA, Watson CM, Spector TD, Uitterlinden AG, Valdes AM, Ioannidis JP., Free PMC Articles: PMC4412885, PMC4412885 | 01/21/2010 |
| Meta-analysis of gene-disease association. (HuGE Navigator) | Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand.
Evangelou E, Chapman K, Meulenbelt I, Karassa FB, Loughlin J, Carr A, Doherty M, Doherty S, Gómez-Reino JJ, Gonzalez A, Halldorsson BV, Hauksson VB, Hofman A, Hart DJ, Ikegawa S, Ingvarsson T, Jiang Q, Jonsdottir I, Jonsson H, Kerkhof HJ, Kloppenburg M, Lane NE, Li J, Lories RJ, van Meurs JB, Näkki A, Nevitt MC, Rodriguez-Lopez J, Shi D, Slagboom PE, Stefansson K, Tsezou A, Wallis GA, Watson CM, Spector TD, Uitterlinden AG, Valdes AM, Ioannidis JP, Evangelou E, Chapman K, Meulenbelt I, Karassa FB, Loughlin J, Carr A, Doherty M, Doherty S, Gómez-Reino JJ, Gonzalez A, Halldorsson BV, Hauksson VB, Hofman A, Hart DJ, Ikegawa S, Ingvarsson T, Jiang Q, Jonsdottir I, Jonsson H, Kerkhof HJ, Kloppenburg M, Lane NE, Li J, Lories RJ, van Meurs JB, Näkki A, Nevitt MC, Rodriguez-Lopez J, Shi D, Slagboom PE, Stefansson K, Tsezou A, Wallis GA, Watson CM, Spector TD, Uitterlinden AG, Valdes AM, Ioannidis JP., Free PMC Articles: PMC4412885, PMC4412885 | 06/24/2009 |
| Study showed no association between the FRZB polymorphisms or haplotypes and the risk of colorectal cancer or adenoma overall. | Genetic variants in frizzled-related protein (FRZB) and the risk of colorectal neoplasia.
Berndt SI, Huang WY, Yeager M, Weissfeld JL, Chanock SJ, Hayes RB, Berndt SI, Huang WY, Yeager M, Weissfeld JL, Chanock SJ, Hayes RB., Free PMC Articles: PMC2667207, PMC2667207 | 01/21/2010 |
| No association was seen between FRZB, LRP5 and LRP6 variants with radiographic osteoarthritic outcomes in two population-based cohorts | Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts.
Kerkhof JM, Uitterlinden AG, Valdes AM, Hart DJ, Rivadeneira F, Jhamai M, Hofman A, Pols HA, Bierma-Zeinstra SM, Spector TD, van Meurs JB, Kerkhof JM, Uitterlinden AG, Valdes AM, Hart DJ, Rivadeneira F, Jhamai M, Hofman A, Pols HA, Bierma-Zeinstra SM, Spector TD, van Meurs JB. | 01/21/2010 |
| Usefulness of Frzb in modulating Met signaling as a new treatment strategy for soft tissue sarcomas. | Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling.
Guo Y, Xie J, Rubin E, Tang YX, Lin F, Zi X, Hoang BH., Free PMC Article | 01/21/2010 |
| FRZB suppressed gastric cancer cell proliferation and modulated the balance between proliferation and differentiation in gastric cancer. | Over-expression of FRZB in gastric cancer cell suppresses proliferation and induces differentiation.
Qu Y, Li JF, Cai Q, Wang YW, Gu QL, Zhu ZG, Liu BY. | 01/21/2010 |
| Observational study and meta-analysis of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesRadiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts.
Kerkhof JM, Uitterlinden AG, Valdes AM, Hart DJ, Rivadeneira F, Jhamai M, Hofman A, Pols HA, Bierma-Zeinstra SM, Spector TD, van Meurs JB, Kerkhof JM, Uitterlinden AG, Valdes AM, Hart DJ, Rivadeneira F, Jhamai M, Hofman A, Pols HA, Bierma-Zeinstra SM, Spector TD, van Meurs JB. Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee.
Valdes AM, Loughlin J, Oene MV, Chapman K, Surdulescu GL, Doherty M, Spector TD. | 03/13/2008 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (8) articlesInherited genetic variant predisposes to aggressive but not indolent prostate cancer.
Xu J, Zheng SL, Isaacs SD, Wiley KE, Wiklund F, Sun J, Kader AK, Li G, Purcell LD, Kim ST, Hsu FC, Stattin P, Hugosson J, Adolfsson J, Walsh PC, Trent JM, Duggan D, Carpten J, Grönberg H, Isaacs WB. No association of the polymorphisms of the frizzled-related protein gene with peak bone mineral density in Chinese nuclear families.
Gao G, Zhang ZL, He JW, Zhang H, Yue H, Hu WW, Gu JM, Fu WZ, Hu YQ, Li M, Liu YJ, Yu JB, Gao G, Zhang ZL, He JW, Zhang H, Yue H, Hu WW, Gu JM, Fu WZ, Hu YQ, Li M, Liu YJ, Yu JB. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, MrOS Research Group. Genetic variants in frizzled-related protein (FRZB) and the risk of colorectal neoplasia.
Berndt SI, Huang WY, Yeager M, Weissfeld JL, Chanock SJ, Hayes RB, Berndt SI, Huang WY, Yeager M, Weissfeld JL, Chanock SJ, Hayes RB. Variation in the secreted frizzled-related protein-3 gene and risk of osteolysis and heterotopic ossification after total hip arthroplasty.
Gordon A, Southam L, Loughlin J, Wilson AG, Stockley I, Hamer AJ, Eastell R, Wilkinson JM, Gordon A, Southam L, Loughlin J, Wilson AG, Stockley I, Hamer AJ, Eastell R, Wilkinson JM. The functional genetic variant Arg324Gly of frizzled-related protein is associated with colorectal cancer risk.
Shanmugam KS, Brenner H, Hoffmeister M, Chang-Claude J, Burwinkel B. Further evidence of the role of frizzled-related protein gene polymorphisms in osteoarthritis.
Rodriguez-Lopez J, Pombo-Suarez M, Liz M, Gomez-Reino JJ, Gonzalez A. Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites.
Min JL, Meulenbelt I, Riyazi N, Kloppenburg M, Houwing-Duistermaat JJ, Seymour AB, Pols HA, van Duijn CM, Slagboom PE. | 03/13/2008 |
| The FRZB 200Trp allele may be a marker for ''positive'' bone phenotype after total hip arthroplasty that is characterized by a positive association with the development of heterotopic ossification and a negative association with osteolysis. | Variation in the secreted frizzled-related protein-3 gene and risk of osteolysis and heterotopic ossification after total hip arthroplasty.
Gordon A, Southam L, Loughlin J, Wilson AG, Stockley I, Hamer AJ, Eastell R, Wilkinson JM, Gordon A, Southam L, Loughlin J, Wilson AG, Stockley I, Hamer AJ, Eastell R, Wilkinson JM. | 01/21/2010 |
| In 60 multiple myeloma patients checked, it was found that among the Wnt inhibitors, Dickkopf-1 and secreted frizzled-related protein-3 were produced by multiple myeloma cells. | Production of Wnt inhibitors by myeloma cells: potential effects on canonical Wnt pathway in the bone microenvironment.
Giuliani N, Morandi F, Tagliaferri S, Lazzaretti M, Donofrio G, Bonomini S, Sala R, Mangoni M, Rizzoli V. | 01/21/2010 |