| Data suggest that interaction between the nociceptin/nociceptin receptor system and the orexin/orexin receptor system in neurons of the hypothalamus positively and negatively modulate complex and integrated responses to stress. [REVIEW] | The neuronal circuit between nociceptin/orphanin FQ and hypocretins/orexins coordinately modulates stress-induced analgesia and anxiety-related behavior.
Xie XS. | 09/26/2015 |
| Decrease in Ox expression with normal human maturation and aging. This may contribute to changes in sleep regulation during development and with aging. | Changes in orexin (hypocretin) neuronal expression with normal aging in the human hypothalamus.
Hunt NJ, Rodriguez ML, Waters KA, Machaalani R. | 09/26/2015 |
| Orexin A upregulates the protein expression of OX1R and enhances the proliferation of SGC-7901 gastric cancer cells through the ERK signaling pathway. | Orexin A upregulates the protein expression of OX1R and enhances the proliferation of SGC-7901 gastric cancer cells through the ERK signaling pathway.
Liu Y, Zhao Y, Ju S, Guo L. | 08/22/2015 |
| Orexin receptor binding was strongly dependent on the extracellular Ca(2+) concentration. | Calcium affects OX1 orexin (hypocretin) receptor responses by modifying both orexin binding and the signal transduction machinery.
Putula J, Pihlajamaa T, Kukkonen JP., Free PMC Article | 08/1/2015 |
| No significant differences were found in the distribution of either genotypic or allelic frequencies between Alzheimer's disease cases and controls in the HCRTR1 polymorphisms. | Is HCRTR2 a genetic risk factor for Alzheimer's disease?
Gallone S, Boschi S, Rubino E, De Martino P, Scarpini E, Galimberti D, Fenoglio C, Acutis PL, Maniaci MG, Pinessi L, Rainero I. | 05/16/2015 |
| Orexins modifiy orexin receptor gene expression and gonadotropin release from the anterior pituitary gland. | Orexin A and B in vitro modify orexins receptors expression and gonadotropins secretion of anterior pituitary cells of proestrous rats.
Cataldi NI, Lux Lantos VA, Libertun C. | 10/25/2014 |
| DQ B1 but not HLA-DR typing, TNF-alpha levels, HCRTR1 and HCRTR2 were higher in narcolepsy-cataplexy/schizophrenia patients. | Narcolepsy-cataplexy and schizophrenia in adolescents.
Huang YS, Guilleminault C, Chen CH, Lai PC, Hwang FM. | 09/27/2014 |
| The present data indicate that OX1R-driven apoptosis is overexpressed in androgeno-independent prostate cancer exhibiting a neuroendocrine differentiation opening a gate for novel therapies for these aggressive cancers which are incurable until now. | The orexin type 1 receptor is overexpressed in advanced prostate cancer with a neuroendocrine differentiation, and mediates apoptosis.
Alexandre D, Hautot C, Mehio M, Jeandel L, Courel M, Voisin T, Couvineau A, Gobet F, Leprince J, Pfister C, Anouar Y, Chartrel N. | 08/30/2014 |
| Both orexin receptor subtypes, OX1R and OX2R, and CB1 cannabinoid receptors are capable of forming constitutive homo- and heteromeric complexes. | Human orexin/hypocretin receptors form constitutive homo- and heteromeric complexes with each other and with human CB1 cannabinoid receptors.
Jäntti MH, Mandrika I, Kukkonen JP. | 06/7/2014 |
| [review] Native orexin peptides consist of receptor agonists, orexin-A (33 amino acids) and orexin-B (28 amino acids) (aka hypocretin-1 and hypocretin-2). | Physiology of the orexinergic/hypocretinergic system: a revisit in 2012.
Kukkonen JP. | 03/9/2013 |
| Orexin receptors generate potent endocannabinoid signals in addition to arachidonic acid signals, which may explain the proposed orexin-cannabinoid interactions. | OX1 orexin/hypocretin receptor signaling through arachidonic acid and endocannabinoid release.
Turunen PM, Jäntti MH, Kukkonen JP. | 10/13/2012 |
| decreased ventilatory responses to hypoxia in human narcolepsy-cataplexy is in relation to HLA-DQB1*0602 status, not hypocretin deficiency | Respiratory regulation in narcolepsy.
Han F. | 07/28/2012 |
| Intramolecular fluorescence resonance energy transfer (FRET) sensors of the orexin OX1 and OX2 receptors identify slow kinetics of agonist activation. | Intramolecular fluorescence resonance energy transfer (FRET) sensors of the orexin OX1 and OX2 receptors identify slow kinetics of agonist activation.
Xu TR, Ward RJ, Pediani JD, Milligan G., Free PMC Article | 07/7/2012 |
| HCRTR1 gene could represent a genetic susceptibility factor for migraine without aura; the hypocretin system may have a role in the pathophysiology of migraine. | Evidence for an association between migraine and the hypocretin receptor 1 gene.
Rainero I, Rubino E, Gallone S, Fenoglio P, Picci LR, Giobbe L, Ostacoli L, Pinessi L., Free PMC Article | 03/17/2012 |
| Dynlt1 modulates orexin signaling by regulating OX1R | Dynein light chain Tctex-type 1 modulates orexin signaling through its interaction with orexin 1 receptor.
Duguay D, Bélanger-Nelson E, Mongrain V, Beben A, Khatchadourian A, Cermakian N., Free PMC Article | 02/25/2012 |
| The Ile408Val polymorphism in the hypocretin receptor 1 (HCRTR1) gene and the Val308Iso (G1246A) polymorphism in the hypocretin receptor 2 (HCRTR2) gene in a sample of 215 panic disorder patients and 454 controls, were analyzed. | Panic disorder is associated with the Val308Iso polymorphism in the hypocretin receptor gene.
Annerbrink K, Westberg L, Olsson M, Andersch S, Sjödin I, Holm G, Allgulander C, Eriksson E. | 01/21/2012 |
| Heteromultimerization of cannabinoid CB(1) receptor and orexin OX(1) receptor generates a unique complex in which both protomers are regulated by orexin A. | Heteromultimerization of cannabinoid CB(1) receptor and orexin OX(1) receptor generates a unique complex in which both protomers are regulated by orexin A.
Ward RJ, Pediani JD, Milligan G., Free PMC Article | 12/17/2011 |
| Data show that the HCRTR1 gene or a linked locus may modulate the risk for Major Mood Disorders and supports recent studies suggesting an involvement of hypocretin neurotransmitter system in affective disorders. | Association between major mood disorders and the hypocretin receptor 1 gene.
Rainero I, Ostacoli L, Rubino E, Gallone S, Picci LR, Fenoglio P, Negro E, Rosso C, De Martino P, De Marchi M, Furlan PM, Pinessi L. | 10/8/2011 |
| Results show that the N-terminal regions of orexin receptor are most important, and the exchange of the area from the C-terminal part of the transmembrane helix 2 to the transmembrane helix 4 is enough to lead to a change of the receptor's ligand profile. | Orexin/hypocretin receptor chimaeras reveal structural features important for orexin peptide distinction.
Putula J, Turunen PM, Johansson L, Näsman J, Ra R, Korhonen L, Kukkonen JP. | 08/6/2011 |
| analysis of orexin receptor 1 and 2 -arrestin-ubiquitin complexes | Temporal profiling of orexin receptor-arrestin-ubiquitin complexes reveals differences between receptor subtypes.
Dalrymple MB, Jaeger WC, Eidne KA, Pfleger KD., Free PMC Article | 07/16/2011 |
| In differentiated IMR-32 neuroblastoma cells orexin/hypocretin and bradykinin receptors activate TRPC3/6 channels. | Selective interference with TRPC3/6 channels disrupts OX1 receptor signalling via NCX and reveals a distinct calcium influx pathway.
Louhivuori LM, Jansson L, Nordström T, Bart G, Näsman J, Akerman KE. | 07/2/2011 |
| Data demonstrate the functional role of protein kinase D1 and protein kinase D3 in modulating physiological responses to Ox1R activation. | A role for PKD1 and PKD3 activation in modulation of calcium oscillations induced by orexin receptor 1 stimulation.
Peltonen HM, Akerman KE, Bart G. | 10/30/2010 |
| OX1 orexin receptor activation results in robust arachidonic acid release. | Arachidonic acid release mediated by OX1 orexin receptors.
Turunen PM, Ekholm ME, Somerharju P, Kukkonen JP., Free PMC Article | 05/3/2010 |
| It was shown here that another motif, immunoreceptor tyrosine-based switch motif, is present in orexin receptor-1 (OX1R) and is mandatory for OX1R-mediated apoptosis. | Discovery of a functional immunoreceptor tyrosine-based switch motif in a 7-transmembrane-spanning receptor: role in the orexin receptor OX1R-driven apoptosis.
El Firar A, Voisin T, Rouyer-Fessard C, Ostuni MA, Couvineau A, Laburthe M. | 01/25/2010 |
| OX1R are able to activate TRPC(3)-channel-dependent oscillatory responses independently of store discharge. | Involvement of TRPC3 channels in calcium oscillations mediated by OX(1) orexin receptors.
Peltonen HM, Magga JM, Bart G, Turunen PM, Antikainen MS, Kukkonen JP, Akerman KE. | 01/21/2010 |