| The work thus unveiled a unique function of KRS in the control of cell migration and its pathological implication in metastasis. | Interaction of two translational components, lysyl-tRNA synthetase and p40/37LRP, in plasma membrane promotes laminin-dependent cell migration.
Kim DG, Choi JW, Lee JY, Kim H, Oh YS, Lee JW, Tak YK, Song JM, Razin E, Yun SH, Kim S. | 12/22/2012 |
| Data are consistent with hypothesis that maturation of cytoplasmic KARS precursor is needed to reveal the potent tRNA binding properties of mitochondrial KARS. | Activation of human mitochondrial lysyl-tRNA synthetase upon maturation of its premitochondrial precursor.
Dias J, Octobre G, Kobbi L, Comisso M, Flisiak S, Mirande M. | 03/24/2012 |
| LysRS associates with the Pol domain of GagPol. | Association of mitochondrial Lysyl-tRNA synthetase with HIV-1 GagPol involves catalytic domain of the synthetase and transframe and integrase domains of Pol.
Kobbi L, Octobre G, Dias J, Comisso M, Mirande M. | 09/17/2011 |
| The results suggest that this unique geometry, which reconfigures the LysRS tetramer from alpha(2):alpha(2) to alpha(2)beta(1):beta(1)alpha(2), is designed to control both retention and mobilization of LysRS from the multi-tRNA synthetase complex | Structural context for mobilization of a human tRNA synthetase from its cytoplasmic complex.
Fang P, Zhang HM, Shapiro R, Marshall AG, Schimmel P, Yang XL, Guo M., Free PMC Article | 07/30/2011 |
| The interaction between helix 7 of LysRS and helix 4 of the capsid C-terminal domain of HIV-1 Gag (HIV-CA-CTD) was studied using circular dichromism spectroscopy and molecular dynamics simulation. | In vitro and in silico binding study of the peptide derived from HIV-1 CA-CTD and LysRS as a potential HIV-1 blocking site.
Na Nakorn P, Treesuwan W, Choowongkomon K, Hannongbua S, Boonyalai N. | 05/28/2011 |
| These results underscore the contribution of KARS to the emission of (one of) the principal signal(s) of immunogenic cell death, CRT exposure. | Lysyl tRNA synthetase is required for the translocation of calreticulin to the cell surface in immunogenic death.
Kepp O, Gdoura A, Martins I, Panaretakis T, Schlemmer F, Tesniere A, Fimia GM, Ciccosanti F, Burgevin A, Piacentini M, Eggleton P, Young PJ, Zitvogel L, van Endert P, Kroemer G. | 12/4/2010 |
| Loss-of-function lysyl-tRNA synthetase mutations associated with peripheral neuropathy and Charcot-Marie-Tooth disease. | Compound heterozygosity for loss-of-function lysyl-tRNA synthetase mutations in a patient with peripheral neuropathy.
McLaughlin HM, Sakaguchi R, Liu C, Igarashi T, Pehlivan D, Chu K, Iyer R, Cruz P, Cherukuri PF, Hansen NF, Mullikin JC, NISC Comparative Sequencing Program, Biesecker LG, Wilson TE, Ionasescu V, Nicholson G, Searby C, Talbot K, Vance JM, Züchner S, Szigeti K, Lupski JR, Hou YM, Green ED, Antonellis A., Free PMC Article | 10/30/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.
Segat L, Brandão LAC, Guimarães RL, Pontillo A, Athanasakis E, de Oliveira RM, Arraes LC, de Lima Filho JL, Crovella S. | 06/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGenetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects.
Dastani Z, Pajukanta P, Marcil M, Rudzicz N, Ruel I, Bailey SD, Lee JC, Lemire M, Faith J, Platko J, Rioux J, Hudson TJ, Gaudet D, Engert JC, Genest J. | 12/2/2009 |
| mitoKARS is the first described member of a group of mitochondrial proteins whose interaction with mutant SOD1 contributes to mitochondrial dysfunction in ALS | Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria.
Kawamata H, Magrané J, Kunst C, King MP, Manfredi G., Free PMC Article | 01/21/2010 |
| present a 2.3-A crystal structure of a tetrameric form of human LysRS | Crystal structure of tetrameric form of human lysyl-tRNA synthetase: Implications for multisynthetase complex formation.
Guo M, Ignatov M, Musier-Forsyth K, Schimmel P, Yang XL., Free PMC Article | 01/21/2010 |
| This work reports further characterization of the interaction between HIV-1 capsid domain of Gag and human LysRS using truncation constructs and point mutations in the putative interaction helices. | Critical role of helix 4 of HIV-1 capsid C-terminal domain in interactions with human lysyl-tRNA synthetase.
Kovaleski BJ, Kennedy R, Khorchid A, Kleiman L, Matsuo H, Musier-Forsyth K. | 01/21/2010 |
| HIV-1 Gag interacts with human lysyl-tRNA synthetase during viral assembly | The interaction between HIV-1 Gag and human lysyl-tRNA synthetase during viral assembly.
Javanbakht H, Halwani R, Cen S, Saadatmand J, Musier-Forsyth K, Gottlinger H, Kleiman L. | 01/21/2010 |
| analysis of the interaction between HIV-1 Gag and human lysyl-tRNA synthetase | In vitro characterization of the interaction between HIV-1 Gag and human lysyl-tRNA synthetase.
Kovaleski BJ, Kennedy R, Hong MK, Datta SA, Kleiman L, Rein A, Musier-Forsyth K. | 01/21/2010 |
| packaged into human immunodeficiency virus type 1 (HIV-1) via its interaction with Gag; this enzyme facilitates the selective packaging of tRNA(3)(Lys), the primer for initiating reverse transcription, into HIV-1 | Cellular distribution of Lysyl-tRNA synthetase and its interaction with Gag during human immunodeficiency virus type 1 assembly.
Halwani R, Cen S, Javanbakht H, Saadatmand J, Kim S, Shiba K, Kleiman L., Free PMC Article | 01/21/2010 |
| HIV-1 Vpr fulfills an essential role in the process of packaging of mitochondrial Lysyl-tRNA synthase. | Role of HIV-1 Vpr-induced apoptosis on the release of mitochondrial lysyl-tRNA synthetase.
Kaminska M, Francin M, Shalak V, Mirande M. | 01/21/2010 |