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    MSN moesin [ Homo sapiens (human) ]

    Gene ID: 4478, updated on 9-Jun-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The expression pattern and subcellular localization of ezrin and moesin correlate with clinicopathological variables such as patients' age, tumor grade and hormonal status.

    Expression of ezrin and moesin in primary breast carcinoma and matched lymph node metastases.
    Bartova M, Hlavaty J, Tan Y, Singer C, Pohlodek K, Luha J, Walter I.

    12/9/2017
    Moesin and merlin regulate urokinase receptor-dependent endothelial cell migration, adhesion and angiogenesis

    Moesin and merlin regulate urokinase receptor-dependent endothelial cell migration, adhesion and angiogenesis.
    Degryse B, Britto M, Shan CX, Wallace RG, Rochfort KD, Cummins PM, Meade G, Murphy RP.

    12/2/2017
    The results reveal a supportive role of ERMs in cortical activities during cytokinesis, and also provide insight into the selective mechanism that preferentially associates cytokinesis-relevant proteins with the division site.

    Dynamics and function of ERM proteins during cytokinesis in human cells.
    Hiruma S, Kamasaki T, Otomo K, Nemoto T, Uehara R.

    11/4/2017
    These results indicate that loss of miR-200c, as a consequence of p53 mutation, can upregulate Moesin oncogene and thus promote carcinogenesis in breast cancer

    The role of p53-microRNA 200-Moesin axis in invasion and drug resistance of breast cancer cells.
    Alam F, Mezhal F, El Hasasna H, Nair VA, Aravind SR, Saber Ayad M, El-Serafi A, Abdel-Rahman WM.

    10/21/2017
    the administration of 10(-6) M retinoic acid (10-20 min) induces the activation of the migration-related proteins Moesin, FAK, and Paxillin in T-47D breast cancer cells.

    Retinoic acid induces nuclear FAK translocation and reduces breast cancer cell adhesion through Moesin, FAK, and Paxillin.
    Sanchez AM, Shortrede JE, Vargas-Roig LM, Flamini MI.

    09/30/2017
    Up-regulation of moesin expression in glioblastoma cells correlated with increases in cell proliferation, invasion and migration, suggesting moesin's role in glioblastoma progression.

    Moesin Expression Is Associated with Glioblastoma Cell Proliferation and Invasion.
    Wang Q, Lu X, Zhao S, Pang M, Wu X, Wu H, Hoffman RM, Yang Z, Zhang Y.

    08/12/2017
    this study identifies X-linked primary immunodeficiency associated with hemizygous mutations in the moesin gene

    X-linked primary immunodeficiency associated with hemizygous mutations in the moesin (MSN) gene.
    Lagresle-Peyrou C, Luce S, Ouchani F, Soheili TS, Sadek H, Chouteau M, Durand A, Pic I, Majewski J, Brouzes C, Lambert N, Bohineust A, Verhoeyen E, Cosset FL, Magerus-Chatinet A, Rieux-Laucat F, Gandemer V, Monnier D, Heijmans C, van Gijn M, Dalm VA, Mahlaoui N, Stephan JL, Picard C, Durandy A, Kracker S, Hivroz C, Jabado N, de Saint Basile G, Fischer A, Cavazzana M, André-Schmutz I.

    07/15/2017
    These results of this study may pave the way for exploiting moesin as a novel target for intervention in muscular dystrophy.

    Elevated Expression of Moesin in Muscular Dystrophies.
    Pines M, Levi O, Genin O, Lavy A, Angelini C, Allamand V, Halevy O.

    06/3/2017
    The present study showed over-expression of ezrin and moesin in colorectal carcinoma

    Immunohistochemical assessment of ezrin and moesin in colorectal carcinoma.
    Abdou AG, Sakr S, Elwahed MM, Eladly EK.

    04/1/2017
    These results indicate that the Thr 558 phosphorylation in moesin mediates endothelial angiogenesis. Advanced glycation end products promoted human umbilical vein endothelial cell angiogenesis by inducing moesin phosphorylation via RhoA/ROCK pathway.

    Role of Moesin in Advanced Glycation End Products-Induced Angiogenesis of Human Umbilical Vein Endothelial Cells.
    Wang Q, Fan A, Yuan Y, Chen L, Guo X, Huang X, Huang Q., Free PMC Article

    01/14/2017
    Phospho-Ezrin/Radixin/Moesin (ERM) inhibit cell adhesion, and therefore, dephosphorylation of ERM proteins is essential for cell adhesion.Phospho-ERM induce formation and/or maintenance of spherical cell shape.

    Inhibition of cell adhesion by phosphorylated Ezrin/Radixin/Moesin.
    Tachibana K, Haghparast SM, Miyake J., Free PMC Article

    09/24/2016
    Moesin was required in HMGB1-induced F-actin rearrangement, hyperpermeability, and inflammatory responses. HMGB1 increased Thr558 phosphorylation of moesin. Moesin was elevated in sepsis.

    Role of moesin in HMGB1-stimulated severe inflammatory responses.
    Lee W, Kwon OK, Han MS, Lee YM, Kim SW, Kim KM, Lee T, Lee S, Bae JS.

    06/28/2016
    results indicate Moesin may regulate cell motility through its interactions with MT1-MMP and E-cadherin/p120-catenin adhesion complex and cytoplasmic expression of Moesin correlates with nodal metastasis and poor prognosis of OSCCs

    Moesin regulates the motility of oral cancer cells via MT1-MMP and E-cadherin/p120-catenin adhesion complex.
    Li YY, Zhou CX, Gao Y.

    06/28/2016
    Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion.

    Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion.
    Adada MM, Canals D, Jeong N, Kelkar AD, Hernandez-Corbacho M, Pulkoski-Gross MJ, Donaldson JC, Hannun YA, Obeid LM., Free PMC Article

    02/13/2016
    Moesin might be involved in renal fibrosis and its effects could be related to interacting with E-Cadherin.

    Role of moesin in renal fibrosis.
    Chen YX, Zhang W, Wang WM, Yu XL, Wang YM, Zhang MJ, Chen N., Free PMC Article

    01/16/2016
    Ezrin, radixin and moesin are unlikely targets for autoantibodies in demyelinating neuropathies.

    Are ERM (ezrin/radixin/moesin) proteins targets for autoantibodies in demyelinating neuropathies?
    Miyaji K, Shahrizaila N, Umapathi T, Chan YC, Hirata K, Yuki N.

    08/8/2015
    Ezrin and moesin expression is related to LSCC invasion and metastasis, and may be important molecular markers for predicting prognosis and therapeutic targets in LSCC patients

    Expression of ezrin and moesin related to invasion, metastasis and prognosis of laryngeal squamous cell carcinoma.
    Wang X, Liu M, Zhao CY.

    06/27/2015
    Data show that silencing ezrin-radixin-moesin (ERM) protein expression ablates deleted in colorectal carcinoma protein (DCC)-protein kinase A (PKA) interaction and specifically blocks netrin-induced PKA activity and phosphorylation.

    Anchoring of protein kinase A by ERM (ezrin-radixin-moesin) proteins is required for proper netrin signaling through DCC (deleted in colorectal cancer).
    Deming PB, Campbell SL, Stone JB, Rivard RL, Mercier AL, Howe AK., Free PMC Article

    05/16/2015
    both moesin-mediated inhibition and its localized deactivation by myosin phosphatase are essential for neutrophil polarization and effective neutrophil tracking of pathogens.

    Moesin and myosin phosphatase confine neutrophil orientation in a chemotactic gradient.
    Liu X, Yang T, Suzuki K, Tsukita S, Ishii M, Zhou S, Wang G, Cao L, Qian F, Taylor S, Oh MJ, Levitan I, Ye RD, Carnegie GK, Zhao Y, Malik AB, Xu J., Free PMC Article

    04/25/2015
    STIP1 and moesin may be novel and differential sero-diagnostic markers for psoriasis vulgaris and psoriatic arthritis

    Moesin and stress-induced phosphoprotein-1 are possible sero-diagnostic markers of psoriasis.
    Maejima H, Nagashio R, Yanagita K, Hamada Y, Amoh Y, Sato Y, Katsuoka K., Free PMC Article

    03/7/2015
    present findings suggest that moesin is characteristically overexpressed and activated in adenomyosis, and that moesin activation may be related to extension of adenomyosis in the myometrium.

    Moesin overexpression is a unique biomarker of adenomyosis.
    Ohara R, Michikami H, Nakamura Y, Sakata A, Sakashita S, Satomi K, Shiba-Ishii A, Kano J, Yoshikawa H, Noguchi M.

    12/6/2014
    Moesin was shown to be directly targeted by miR-200b; in breast cancer cell lines and patient samples, its expression is inversely correlated with miR-200 expression, and high levels of moesin were associated with poor relapse-free survival.

    MiR-200 can repress breast cancer metastasis through ZEB1-independent but moesin-dependent pathways.
    Li X, Roslan S, Johnstone CN, Wright JA, Bracken CP, Anderson M, Bert AG, Selth LA, Anderson RL, Goodall GJ, Gregory PA, Khew-Goodall Y.

    09/27/2014
    Moesin expression and CD44 expression might be useful markers of poor prognosis in gastric adenocarcinoma.

    Expression of moesin and CD44 is associated with poor prognosis in gastric adenocarcinoma.
    Jung WY, Kang Y, Lee H, Mok YJ, Kim HK, Kim A, Kim BH.

    09/27/2014
    VIP regulates CFTR membrane expression and function in Calu-3 cells by increasing its interaction with NHERF1 and P-ERM in a VPAC1- and PKCepsilon-dependent manner.

    VIP regulates CFTR membrane expression and function in Calu-3 cells by increasing its interaction with NHERF1 and P-ERM in a VPAC1- and PKCε-dependent manner.
    Alshafie W, Chappe FG, Li M, Anini Y, Chappe VM.

    08/30/2014
    Talin has a role in regulating moesin-NHE-1 recruitment to invadopodia in breast cancer

    Talin regulates moesin-NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis.
    Beaty BT, Wang Y, Bravo-Cordero JJ, Sharma VP, Miskolci V, Hodgson L, Condeelis J., Free PMC Article

    08/9/2014