| Human OAS1 activation is highly dependent on both RNA sequence and context of activating RNA motifs. | Human OAS1 activation is highly dependent on both RNA sequence and context of activating RNA motifs.
Schwartz SL, Park EN, Vachon VK, Danzy S, Lowen AC, Conn GL., Free PMC Article | 09/19/2020 |
| Study of datasets analyzing the gene expression profiles and DNA methylation data of gestational Diabetes Mellitus (GDM) and confirmed through real time PCR in placenta tissue of three GDM samples and three normal samples identified Oas1, Ppie, Polr2g as possible pathogenic target genes of GDM by combining protein-protein interaction analysis. | Comprehensive Analysis of Gene Expression Profiles and DNA Methylome reveals Oas1, Ppie, Polr2g as Pathogenic Target Genes of Gestational Diabetes Mellitus.
Zhang Y, Zhang T, Chen Y., Free PMC Article | 11/23/2019 |
| Children carrying OAS1 rs2660 AG genotype are more likely to have central nervous system involvement after enterovirus71 infection | [OAS1 gene polymorphism is associated with central nervous system involvement in children with enterovirus 71 infection].
Yaping LI, Song Z, Wenjun W, Huiling D, Mei LI, Xiaoli J, Shuangsuo D., Free PMC Article | 08/24/2019 |
| functional variant in the OAS1 gene is associated with Sjogren's syndrome complicated with HBV infection | A functional variant in the OAS1 gene is associated with Sjögren's syndrome complicated with HBV infection.
Liu X, Xing H, Gao W, Yu D, Zhao Y, Shi X, Zhang K, Li P, Yu J, Xu W, Shan H, Zhang K, Bao W, Fu X, Yang S, Wang S., Free PMC Article | 07/13/2019 |
| Data suggest that OAS1 and OAS3 negatively regulate the expression of chemokines and interferon-responsive genes in human macrophages. | OAS1 and OAS3 negatively regulate the expression of chemokines and interferon-responsive genes in human macrophages.
Lee WB, Choi WY, Lee DH, Shim H, Kim-Ha J, Kim YJ., Free PMC Article | 06/22/2019 |
| OAS1 role in the genetic susceptibility to West Nile virus disease.[meta-analysis] | Identification of genetic variants associated with dengue or West Nile virus disease: a systematic review and meta-analysis.
Cahill ME, Conley S, DeWan AT, Montgomery RR., Free PMC Article | 05/4/2019 |
| The G allele of rs10774671 was a significantly protective factor against tuberculosis and the genotype of GG differed significantly between tuberculosis patients and controls under the codominant model. rs1131454 G allele and GG genotype were protective against tuberculosis in the Chinese Han population | 2'-5'-Oligoadenylate synthetase 1 polymorphisms are associated with tuberculosis: a case-control study.
Wu S, Wang Y, Chen G, Zhang M, Wang M, He JQ., Free PMC Article | 04/27/2019 |
| two additional de novo heterozygous missense variations of OAS1 in two unrelated simplex individuals also manifesting infantile-onset Pulmonary alveolar proteinosis with hypogammaglobulinemia. | Heterozygous Mutations in OAS1 Cause Infantile-Onset Pulmonary Alveolar Proteinosis with Hypogammaglobulinemia.
Cho K, Yamada M, Agematsu K, Kanegane H, Miyake N, Ueki M, Akimoto T, Kobayashi N, Ikemoto S, Tanino M, Fujita A, Hayasaka I, Miyamoto S, Tanaka-Kubota M, Nakata K, Shiina M, Ogata K, Minakami H, Matsumoto N, Ariga T., Free PMC Article | 12/22/2018 |
| Mx1 and OAS1-2 polymorphisms were associated with the severity of liver disease in HIV/HCV-coinfected patients, suggesting a significant role in the progression of hepatic fibrosis. | Mx1, OAS1 and OAS2 polymorphisms are associated with the severity of liver disease in HIV/HCV-coinfected patients: A cross-sectional study.
García-Álvarez M, Berenguer J, Jiménez-Sousa MA, Pineda-Tenor D, Aldámiz-Echevarria T, Tejerina F, Diez C, Vázquez-Morón S, Resino S., Free PMC Article | 10/27/2018 |
| Relative expression of OAS1 and Mx1 in patients with recurrent forms of Herpes simplex both during the acute stage and clinical remission did not differ significantly from that in healthy people after stimulation with IFN-alpha2b. | Expression of IFN-Inducible Genes with Antiviral Function OAS1 and MX1 in Health and under Conditions of Recurrent Herpes Simplex Infection.
Karaulov AV, Shulzhenko AE, Karsonova AV. | 04/21/2018 |
| OAS1 rs2057778) genotype was significantly related to severe necroinflammatory activity (NIA) grade of chronic hepatitis C patients. | Interferon-related genetic markers of necroinflammatory activity in chronic hepatitis C.
López-Rodríguez R, Hernández-Bartolomé Á, Borque MJ, Rodríguez-Muñoz Y, Martín-Vílchez S, García-Buey L, González-Moreno L, Real-Martínez Y, Muñoz de Rueda P, Salmerón J, Vidal-Castiñeira JR, López-Larrea C, Rodrigo L, Moreno-Otero R, Sanz-Cameno P., Free PMC Article | 10/7/2017 |
| Our results establish OAS1 as a risk locus for Sjogren's syndrome and support a potential role for defective viral clearance due to altered IFN response as a genetic pathophysiological basis of this complex autoimmune disease | Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons.
Li H, Reksten TR, Ice JA, Kelly JA, Adrianto I, Rasmussen A, Wang S, He B, Grundahl KM, Glenn SB, Miceli-Richard C, Bowman S, Lester S, Eriksson P, Eloranta ML, Brun JG, Gøransson LG, Harboe E, Guthridge JM, Kaufman KM, Kvarnström M, Cunninghame Graham DS, Patel K, Adler AJ, Farris AD, Brennan MT, Chodosh J, Gopalakrishnan R, Weisman MH, Venuturupalli S, Wallace DJ, Hefner KS, Houston GD, Huang AJW, Hughes PJ, Lewis DM, Radfar L, Vista ES, Edgar CE, Rohrer MD, Stone DU, Vyse TJ, Harley JB, Gaffney PM, James JA, Turner S, Alevizos I, Anaya JM, Rhodus NL, Segal BM, Montgomery CG, Scofield RH, Kovats S, Mariette X, Rönnblom L, Witte T, Rischmueller M, Wahren-Herlenius M, Omdal R, Jonsson R, Ng WF, for UK Primary Sjögren's Syndrome Registry, Nordmark G, Lessard CJ, Sivils KL., Free PMC Article | 07/22/2017 |
| we characterized the functional consequences of the Neandertal haplotype in the transcriptional regulation of OAS genes at baseline and infected conditions. We found that cells from people with the Neandertal-like haplotype express lower levels of OAS3 upon infection, as well as distinct isoforms of OAS1 and OAS2 | Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans.
Sams AJ, Dumaine A, Nédélec Y, Yotova V, Alfieri C, Tanner JE, Messer PW, Barreiro LB., Free PMC Article | 06/24/2017 |
| In insulitic islets from living patients with recent-onset T1D, most of the overexpressed ISGs, including GBP1, TLR3, OAS1, EIF2AK2, HLA-E, IFI6, and STAT1, showed higher expression in the islet core compared with the peri-islet area containing the surrounding immune cells | Expression of Interferon-Stimulated Genes in Insulitic Pancreatic Islets of Patients Recently Diagnosed With Type 1 Diabetes.
Lundberg M, Krogvold L, Kuric E, Dahl-Jørgensen K, Skog O. | 05/20/2017 |
| ELF-1 binds an important duplicated GGAA cis-acting element at the OAS1 promoter and in cooperation with RB1 and SP1 recruitment contributes to regulation in response to IFN stimulation. | The hematopoietic regulator, ELF-1, enhances the transcriptional response to Interferon-β of the OAS1 anti-viral gene.
Larsen S, Kawamoto S, Tanuma S, Uchiumi F., Free PMC Article | 10/22/2016 |
| Knockdown of OAS1 rescues Lipopolysaccharide-induced cell death and thus may be a promising therapeutic strategy for orthopedic diseases. | Low expression of microRNA-21 contributes to LPS-induced osteoblast cell apoptosis through up-regulation of OAS1.
Li Y, Jiang JL, Yang JS, Gao L. | 08/20/2016 |
| The multivariate analysis showed that the OAS1 GA and AA genotypes were independent factors associated with liver fibrosis progression (p = 0.009, odds ratio [OR] 3.467, 95% confidence interval [CI] 1.273-7.584). | Impact of OAS1 Exon 7 rs10774671 Genetic Variation on Liver Fibrosis Progression in Egyptian HCV Genotype 4 Patients.
Bader El Din NG, Anany MA, Dawood RM, Ibrahim MK, El-Shenawy R, El Abd YS, El Awady MK. | 08/13/2016 |
| Preliminary study suggests that OAS gene cluster and CD209 gene polymorphisms influence the risk of developing clinical symptoms in Chikungunya virus-infected patients. | Association of Oligoadenylate Synthetase Gene Cluster and DC-SIGN (CD209) Gene Polymorphisms with Clinical Symptoms in Chikungunya Virus Infection.
Chaaithanya IK, Muruganandam N, Surya P, Anwesh M, Alagarasu K, Vijayachari P. | 05/28/2016 |
| While both OAS1-p42 and p46 showed antiviral activity against Dengue irus 2, only OAS1-p42 presented anti-Dengue irus 1 activity. | High Anti-Dengue Virus Activity of the OAS Gene Family Is Associated With Increased Severity of Dengue.
Simon-Loriere E, Lin RJ, Kalayanarooj SM, Chuansumrit A, Casademont I, Lin SY, Yu HP, Lert-Itthiporn W, Chaiyaratana W, Tangthawornchaikul N, Tangnararatchakit K, Vasanawathana S, Chang BL, Suriyaphol P, Yoksan S, Malasit P, Despres P, Paul R, Lin YL, Sakuntabhai A. | 03/12/2016 |
| No association is identified between OAS1 SNP and susceptibility to spontaneous preterm birth (SPTB) and preterm premature rupture of membranes (PPROM). | [A case-control study on association between OAS1 polymorphism and susceptibility to spontaneous preterm birth and preterm premature rupture of membranes].
Yang X, Zhang XA, Wu ZH, Peng W, Zhu LN, Wang Y. | 02/6/2016 |
| along with TLR3, functions as a virus recognition receptor on mast cells activating the latent form of RNase L, leading to viral RNA degradation | Roles of retinoic acid-inducible gene-I-like receptors (RLRs), Toll-like receptor (TLR) 3 and 2'-5' oligoadenylate synthetase as viral recognition receptors on human mast cells in response to viral infection.
Tsutsui-Takeuchi M, Ushio H, Fukuda M, Yamada T, Niyonsaba F, Okumura K, Ogawa H, Ikeda S., Free PMC Article | 12/19/2015 |
| our research shows that the OAS1 rs10774671 SNP is associated with CA16 susceptibility and is correlated with mild and severe HFMD. | Association analysis of polymorphisms in OAS1 with susceptibility and severity of hand, foot and mouth disease.
Cai Y, Chen Q, Zhou W, Chu C, Ji W, Ding Y, Xu J, Ji Z, You H, Wang J. | 05/30/2015 |
| The IFNs inhibit viral infections in part through the 2',5'-oligoadenylate (2-5A) synthetase (OAS)/RNase L pathway. | Viral phosphodiesterases that antagonize double-stranded RNA signaling to RNase L by degrading 2-5A.
Silverman RH, Weiss SR., Free PMC Article | 04/4/2015 |
| The findings represent discovery of a novel signature for OAS1 activation, the 3'-single-stranded pyrimidine (3'-ssPy) motif, with potential functional implications for OAS1 activity in its antiviral and other anti-proliferative roles. | A novel RNA molecular signature for activation of 2'-5' oligoadenylate synthetase-1.
Vachon VK, Calderon BM, Conn GL., Free PMC Article | 03/21/2015 |
| The OAS1 p46 isoform localizes to the mitochondria. | Mitochondrial localization of the OAS1 p46 isoform associated with a common single nucleotide polymorphism.
Kjær KH, Pahus J, Hansen MF, Poulsen JB, Christensen EI, Justesen J, Martensen PM., Free PMC Article | 01/24/2015 |