| cisplatin-triggered activation of AMPK and subsequent suppression of mTOR activity can induce an autophagic response that protects tumour cells from cisplatin-mediated apoptotic death | AMPK-mediated autophagy inhibits apoptosis in cisplatin-treated tumour cells.
Harhaji-Trajkovic L, Vilimanovich U, Kravic-Stevovic T, Bumbasirevic V, Trajkovic V., Free PMC Article | 12/24/2011 |
| Studies indicate that in most species, AMPK exists as an obligate heterotrimer, containing a catalytic subunit (alpha), and two regulatory subunits (beta and gamma). | The AMPK signalling pathway coordinates cell growth, autophagy and metabolism.
Mihaylova MM, Shaw RJ., Free PMC Article | 12/10/2011 |
| NT5C1A suppression promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle | Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle.
Kulkarni SS, Karlsson HK, Szekeres F, Chibalin AV, Krook A, Zierath JR., Free PMC Article | 12/10/2011 |
| LKB1-AMPK negatively regulated mTOR function in tumor. | [Advances of LKB1-AMPK-mTOR Signaling Pathway in Tumor].
Zhang X, Sun L, Zhong D., Free PMC Article | 12/10/2011 |
| Inactivation of fumarate hydratase drives a metabolic shift to aerobic glycolysis in FH-de fi cient kidney tumors resulting in decreased levels of AMP-activated kinase. | The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels.
Tong WH, Sourbier C, Kovtunovych G, Jeong SY, Vira M, Ghosh M, Romero VV, Sougrat R, Vaulont S, Viollet B, Kim YS, Lee S, Trepel J, Srinivasan R, Bratslavsky G, Yang Y, Linehan WM, Rouault TA., Free PMC Article | 11/12/2011 |
| Findings reveal that hypoxia can trigger AMPK activation in the apparent absence of increased [AMP] through ROS-dependent CRAC channel activation, leading to increases in cytosolic calcium that activate the AMPK upstream kinase CaMKKbeta. | Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels.
Mungai PT, Waypa GB, Jairaman A, Prakriya M, Dokic D, Ball MK, Schumacker PT., Free PMC Article | 10/15/2011 |
| Phosphorylation of AMPK by Ulk1 represents a negative feedback circuit. | Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.
Löffler AS, Alers S, Dieterle AM, Keppeler H, Franz-Wachtel M, Kundu M, Campbell DG, Wesselborg S, Alessi DR, Stork B. | 10/8/2011 |
| Androgen deprivation and hypoxia augmented AMPK activation and triggered autophagy in androgen-dependent prostate cancer cells. | AMPK-mediated autophagy is a survival mechanism in androgen-dependent prostate cancer cells subjected to androgen deprivation and hypoxia.
Chhipa RR, Wu Y, Ip C., Free PMC Article | 10/8/2011 |
| Glucose deprivation resulted in activation of AMPK and inhibition of Akt phosphorylation | Glucose deprivation activates AMPK and induces cell death through modulation of Akt in ovarian cancer cells.
Priebe A, Tan L, Wahl H, Kueck A, He G, Kwok R, Opipari A, Liu JR. | 09/24/2011 |
| Glucose restriction or treatment of human diploid fibroblasts (HDFs) with the activators of the AMPK/p53 pathway induced the expression of IFI16 protein. | IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway.
Duan X, Ponomareva L, Veeranki S, Choubey D., Free PMC Article | 09/3/2011 |
| results of this study show that AMPK induces MUC5B expression through the p38 MAPK signaling pathway in airway epithelial cells. | AMPK induces MUC5B expression via p38 MAPK in NCI-H292 airway epithelial cells.
Bae CH, Kim JW, Ye SB, Song SY, Kim YW, Park SY, Kim YD. | 09/3/2011 |
| The connections between AMPK and FoxO3A, are reviewed. | The AMPK-FoxO3A axis as a target for cancer treatment.
Chiacchiera F, Simone C. | 09/3/2011 |
| The aim of this study was to investigate the effects of adiponectin on StAR protein expression, steroidogenic genes, and cortisol production and to dissect the signalling cascades involved in the activation of StAR expression. | Adiponectin (15-36) stimulates steroidogenic acute regulatory (StAR) protein expression and cortisol production in human adrenocortical cells: role of AMPK and MAPK kinase pathways.
Ramanjaneya M, Conner AC, Brown JE, Chen J, Digby JE, Barber TM, Lehnert H, Randeva HS. | 07/23/2011 |
| High AMPK expression is associated with ovarian carcinoma. | Prognostic impact of AMP-activated protein kinase expression in ovarian carcinoma: correlation of protein expression and GC/TOF-MS-based metabolomics.
Buckendahl AC, Budczies J, Fiehn O, Darb-Esfahani S, Kind T, Noske A, Weichert W, Sehouli J, Braicu E, Dietel M, Denkert C. | 07/16/2011 |
| Compared with slow-twitch fibers, there was less AMP-activated protein kinase (AMPK)-alpha(1) ( approximately 25%) and AMPK-beta(1) ( approximately 60%) in fast-twitch fibers from human skeletal muscle biopsies. | Enhanced technique to measure proteins in single segments of human skeletal muscle fibers: fiber-type dependence of AMPK-alpha1 and -beta1.
Murphy RM. | 07/9/2011 |
| AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer's disease and other tauopathies. | AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer's disease and other tauopathies.
Vingtdeux V, Davies P, Dickson DW, Marambaud P., Free PMC Article | 06/18/2011 |
| Results suggest that AMPK association with ULK1 plays an important role in autophagy induction. | The association of AMPK with ULK1 regulates autophagy.
Lee JW, Park S, Takahashi Y, Wang HG., Free PMC Article | 04/30/2011 |
| Endoplasmic reticulum stress triggers suppression of AMPK while increasing C/EBPbeta and pCREB expression which activates PEPCK gene transcription. | C/EBPβ is AMP kinase sensitive and up-regulates PEPCK in response to ER stress in hepatoma cells.
Choudhury M, Qadri I, Rahman SM, Schroeder-Gloeckler J, Janssen RC, Friedman JE., Free PMC Article | 03/5/2011 |
| There is a mutual suppressive interaction between AMPK and Akt. | Regulation of mutual inhibitory activities between AMPK and Akt with quercetin in MCF-7 breast cancer cells.
Lee YK, Park OJ. | 02/26/2011 |
| AMPK-mediated PLD1 activation is required for (14)C-glucose uptake through ERK stimulation | Phospholipase D1 mediates AMP-activated protein kinase signaling for glucose uptake.
Kim JH, Park JM, Yea K, Kim HW, Suh PG, Ryu SH., Free PMC Article | 01/15/2011 |
| The LKB1/AMPK/TSC tumor suppressor axis is functional in acute myeloid leukemia. | The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation.
Green AS, Chapuis N, Maciel TT, Willems L, Lambert M, Arnoult C, Boyer O, Bardet V, Park S, Foretz M, Viollet B, Ifrah N, Dreyfus F, Hermine O, Moura IC, Lacombe C, Mayeux P, Bouscary D, Tamburini J. | 01/1/2011 |
| These results suggest that the modification introduced by the laforin-malin complex could affect the subcellular distribution of AMPK beta subunits. | The laforin-malin complex, involved in Lafora disease, promotes the incorporation of K63-linked ubiquitin chains into AMP-activated protein kinase beta subunits.
Moreno D, Towler MC, Hardie DG, Knecht E, Sanz P., Free PMC Article | 11/27/2010 |
| Data suggest that AMPK is required for the serum starvation-related increase in insulin-stimulated glucose transport, with ATM as a possible downstream effector. | A role for AMPK in increased insulin action after serum starvation.
Ching JK, Rajguru P, Marupudi N, Banerjee S, Fisher JS., Free PMC Article | 11/27/2010 |
| The nuclear translocation of GAPDH might be regulated by the PI3K signaling pathway acting mainly as a nuclear export signal and the AMPK signaling pathway acting as a nuclear import signal. | Activation of AMP-activated protein kinase stimulates the nuclear localization of glyceraldehyde 3-phosphate dehydrogenase in human diploid fibroblasts.
Kwon HJ, Rhim JH, Jang IS, Kim GE, Park SC, Yeo EJ., Free PMC Article | 09/27/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.
Jablonski KA, McAteer JB, de Bakker PI, Franks PW, Pollin TI, Hanson RL, Saxena R, Fowler S, Shuldiner AR, Knowler WC, Altshuler D, Florez JC, Diabetes Prevention Program Research Group., Free PMC Article | 09/15/2010 |