| These data provide critical insights into the transcriptional regulation of the IP gene in human megakaryocytic and endothelial cells, identifying Sp1, PU.1 and Oct-1 as the critical factors involved in its basal regulation in humans. | Transcriptional regulation of the human prostacyclin receptor gene is dependent on Sp1, PU.1 and Oct-1 in megakaryocytes and endothelial cells.
Turner EC, Kinsella BT. | 01/21/2010 |
| The prostacyclin receptor plays a central role in regulating its recycling following agonist activation by rab11 protein binding domain within its C-tail domain. | Recycling of the human prostacyclin receptor is regulated through a direct interaction with Rab11a GTPase.
Wikström K, Reid HM, Hill M, English KA, O'Keeffe MB, Kimbembe CC, Kinsella BT. | 01/21/2010 |
| Co-stimulation of G(s) and G(q) can result in the fine-tuning of STAT3 activation status, and this may provide the basis for cell type-specific responses following activation of hIP. | Prostacyclin receptor-induced STAT3 phosphorylation in human erythroleukemia cells is mediated via Galpha(s) and Galpha(16) hybrid signaling.
Lo RK, Liu AM, Wise H, Wong YH. | 01/21/2010 |
| Data suggest that expression of prostanoid receptors (prostaglandin E2 EP3-I, prostacyclin, and thromboxane A2 receptors) in vascular inflammation could influence cell responses dependent on the constitutive activation of ghrelin receptors. | The constitutive activity of ghrelin receptors is decreased by co-expression with vasoactive prostanoid receptors when over-expressed in human embryonic kidney 293 cells.
Chow KB, Leung PK, Cheng CH, Cheung WT, Wise H. | 01/21/2010 |
| A propensity of enhanced platelet activation in deep vein thrombosis patients with PTGIR polymorphisms V53V/S328S; A dysfunctional PTGIR polymorphism (R212C) associated with intimal hyperplasia. | Differential association between human prostacyclin receptor polymorphisms and the development of venous thrombosis and intimal hyperplasia: a clinical biomarker study.
Patrignani P, Di Febbo C, Tacconelli S, Douville K, Guglielmi MD, Horvath RJ, Ding M, Sierra K, Stitham J, Gleim S, Baccante G, Moretta V, Di Francesco L, Capone ML, Porreca E, Hwa J, Patrignani P, Di Febbo C, Tacconelli S, Douville K, Guglielmi MD, Horvath RJ, Ding M, Sierra K, Stitham J, Gleim S, Baccante G, Moretta V, Di Francesco L, Capone ML, Porreca E, Hwa J. | 01/21/2010 |
| diminished prostacyclin receptor signaling may contribute, in part, to the underlying adverse cardiovascular outcomes observed with cyclooxygenase-2 inhibition. | Acceleration of cardiovascular disease by a dysfunctional prostacyclin receptor mutation: potential implications for cyclooxygenase-2 inhibition.
Arehart E, Stitham J, Asselbergs FW, Douville K, MacKenzie T, Fetalvero KM, Gleim S, Kasza Z, Rao Y, Martel L, Segel S, Robb J, Kaplan A, Simons M, Powell RJ, Moore JH, Rimm EB, Martin KA, Hwa J., Free PMC Article | 01/21/2010 |
| A profile of the residues in the second extracellular loop that are critical for ligand recognition of human prostacyclin receptor | A profile of the residues in the second extracellular loop that are critical for ligand recognition of human prostacyclin receptor.
Ni F, So SP, Cervantes V, Ruan KH., Free PMC Article | 01/21/2010 |
| The charged residues and the presence of naturally occurring mutations in prostacyclin receptor have important implications in the rational design of prostacyclin agonists for treating cardiovascular disease. | New insights into human prostacyclin receptor structure and function through natural and synthetic mutations of transmembrane charged residues.
Stitham J, Arehart E, Gleim SR, Li N, Douville K, Hwa J., Free PMC Article | 01/21/2010 |
| IP-receptor agonists may limit the mitogenic actions of thrombin in human SMC by downregulating PAR-1 via modulation of cAMP-/PKA- and Rac1-dependent signaling pathways. | Transcriptional inhibition of protease-activated receptor-1 expression by prostacyclin in human vascular smooth muscle cells.
Pape R, Rauch BH, Rosenkranz AC, Kaber G, Schrör K. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (5) articlesNew genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. A common variant in DRD3 receptor is associated with autism spectrum disorder.
de Krom M, Staal WG, Ophoff RA, Hendriks J, Buitelaar J, Franke B, de Jonge MV, Bolton P, Collier D, Curran S, van Engeland H, van Ree JM. Differential association between human prostacyclin receptor polymorphisms and the development of venous thrombosis and intimal hyperplasia: a clinical biomarker study.
Patrignani P, Di Febbo C, Tacconelli S, Douville K, Guglielmi MD, Horvath RJ, Ding M, Sierra K, Stitham J, Gleim S, Baccante G, Moretta V, Di Francesco L, Capone ML, Porreca E, Hwa J, Patrignani P, Di Febbo C, Tacconelli S, Douville K, Guglielmi MD, Horvath RJ, Ding M, Sierra K, Stitham J, Gleim S, Baccante G, Moretta V, Di Francesco L, Capone ML, Porreca E, Hwa J. Association between polymorphisms in prostanoid receptor genes and aspirin-intolerant asthma.
Kim SH, Kim YK, Park HW, Jee YK, Kim SH, Bahn JW, Chang YS, Kim SH, Ye YM, Shin ES, Lee JE, Park HS, Min KU. | 03/13/2008 |
| Prostaglandin I(2) receptor (IP) was more specifically expressed in hair cuticle layer and outer root sheath (ORS) basal layer. | Prostanoid receptors in anagen human hair follicles.
Colombe L, Michelet JF, Bernard BA. | 01/21/2010 |
| These data suggest that iloprost modulates VSMC phenotype via G(s) activation of the cAMP/PKA pathway. | The prostacyclin receptor induces human vascular smooth muscle cell differentiation via the protein kinase A pathway.
Fetalvero KM, Shyu M, Nomikos AP, Chiu YF, Wagner RJ, Powell RJ, Hwa J, Martin KA. | 01/21/2010 |
| PGI-IP interaction within glandular epithelial cells can promote the expression of proangiogenic genes in human endometrium via cross talk with the EGFR. | Prostacyclin receptor up-regulates the expression of angiogenic genes in human endometrium via cross talk with epidermal growth factor Receptor and the extracellular signaling receptor kinase 1/2 pathway.
Smith OP, Battersby S, Sales KJ, Critchley HO, Jabbour HN. | 01/21/2010 |
| the presence of a free heavy chain IgG in the circulation from spinal cord-injured subjects blocked insulin receptor binding sites and also blocked the prostacyclin receptor interaction in platelets; insulin-induced NO synthesis was markedly impaired. | Circulating heavy chain IgG, a pathological mediator for coronary artery disease, recognizes platelet surface receptors of both prostacyclin and insulin.
Kahn NN, Bauman WA, Sinha AK. | 01/21/2010 |
| The -CSLC motif of the IP is a direct target for inhibition by the FTI SCH66336, and in the presence of strong farnesyltransferase inhibition, the IP does not undergo compensatory geranylgeranylation. | The effect of the farnesyl protein transferase inhibitor SCH66336 on isoprenylation and signalling by the prostacyclin receptor.
O'Meara SJ, Kinsella BT., Free PMC Article | 01/21/2010 |
| Data show that prostacyclin receptor mediated increases in cAMP play a role in enhancing LPS/IFN-gamma-induced iNOS expression in human monocytes/macrophages and may contribute to the increased production of NO during peritonitis. | Prostacyclin enhances the expression of LPS/INF-gamma-induced nitric oxide synthase in human monocytes.
Plum J, Huang C, Grabensee B, Schrör K, Meyer-Kirchrath J. | 01/21/2010 |
| analysis of roles of cysteine residues in human prostacyclin receptor structure and function | Versatility and differential roles of cysteine residues in human prostacyclin receptor structure and function.
Stitham J, Gleim SR, Douville K, Arehart E, Hwa J. | 01/21/2010 |
| activation-dependent internalization of this receptor | Activation-dependent internalization of the human prostacyclin receptor.
Smyth EM, Austin SC, FitzGerald GA. | 01/21/2010 |
| current state of knowledge of the prostacyclin receptor, its signaling and regulation, and its biological role in vivo [review] | Human prostacyclin receptor.
Smyth EM, FitzGerald GA. | 01/21/2010 |
| AC6 overexpression in endothelial cells may have use as a means to enhance prostacyclin function and reduce endothelial barrier permeability. | Adenylyl cyclase 6 overexpression decreases the permeability of endothelial monolayers via preferential enhancement of prostacyclin receptor function.
Bundey RA, Insel PA. | 01/21/2010 |
| identification of a unique ligand-binding pocket by site-directed mutagenesis and molecular modeling | The unique ligand-binding pocket for the human prostacyclin receptor. Site-directed mutagenesis and molecular modeling.
Stitham J, Stojanovic A, Merenick BL, O'Hara KA, Hwa J. | 01/21/2010 |
| Iloprost stimulation (1 microM, 2 h) of IP prostanoid receptor expressed in HEK293 cells resulted in specific decrease of endogenous G(s)alpha protein in detergent-insensitive, caveolin-enriched, membrane domains | Long-term agonist stimulation of IP prostanoid receptor depletes the cognate G(s)alpha protein in membrane domains but does not change the receptor level.
Moravcová Z, Rudajev V, Stöhr J, Novotný J, Cerný J, Parenti M, Milligan G, Svoboda P. | 01/21/2010 |
| role in protein isoprenylation | Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor.
Miggin SM, Lawler OA, Kinsella BT. | 01/21/2010 |
| Impaired receptor binding and activation associated with polymorphism | Impaired receptor binding and activation associated with a human prostacyclin receptor polymorphism.
Stitham J, Stojanovic A, Hwa J. | 01/21/2010 |
| prostacyclin and thromboxane receptor dimerization facilitates thromboxane receptor-mediated cAMP generation | Dimerization of the human receptors for prostacyclin and thromboxane facilitates thromboxane receptor-mediated cAMP generation.
Wilson SJ, Roche AM, Kostetskaia E, Smyth EM. | 01/21/2010 |