| Populations with both COX-2 -765GG and PGIS CC genotypes were more at risk for myocardial infarction. | [Study on the association of cyclooxygenase-2 -765g>C and prostacyclin synthase C1117A polymorphisms and the risk of myocardial infarction in Uigur population of Xinjiang, China].
Xie X, Ma YT, Fu ZY, Yang YN, Wang YH, Chen BD, Liu F. | 01/21/2010 |
| Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) | A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers.
Young RP, Hopkins RJ, Hay BA, Epton MJ, Mills GD, Black PN, Gardner HD, Sullivan R, Gamble GD. | 12/2/2009 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Association of genetic variants with chronic kidney disease in individuals with different lipid profiles.
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nishigaki Y, Nozawa Y, Yamada Y. | 09/20/2009 |
| The CC genotype of CYP8A1 is associated with myocardial infarction(MI), respectively. | Association of polymorphisms of PTGS2 and CYP8A1 with myocardial infarction.
Xie X, Ma YT, Fu ZY, Yang YN, Ma X, Chen BD, Wang YH, Liu F, Xie X, Ma YT, Fu ZY, Yang YN, Ma X, Chen BD, Wang YH, Liu F. | 01/21/2010 |
| PTGIS genetic variation is associated with incident myocardial infarction. Carriers of rs20417C allele may derive greater benefits from aspirin use. | Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke.
Lemaitre RN, Rice K, Marciante K, Bis JC, Lumley TS, Wiggins KL, Smith NL, Heckbert SR, Psaty BM, Lemaitre RN, Rice K, Marciante K, Bis JC, Lumley TS, Wiggins KL, Smith NL, Heckbert SR, Psaty BM., Free PMC Articles: PMC2753183, PMC2753183 | 01/21/2010 |
| rs237484 is in proximity to the potassium voltage gate channel gene (KCNB1) and close to the prostaglandin I2 (prostacyclin) synthase gene (PTGIS). | A quantitative trait locus for SBP maps near KCNB1 and PTGIS in a population isolate.
Barbalić M, Narancić NS, Skarić-Jurić T, Salihović MP, Klarić IM, Lauc LB, Janićijević B, Farrall M, Rudan I, Campbell H, Wright AF, Hastie ND, Rudan P, Barbalić M, Narancić NS, Skarić-Jurić T, Salihović MP, Klarić IM, Lauc LB, Janićijević B, Farrall M, Rudan I, Campbell H, Wright AF, Hastie ND, Rudan P. | 01/21/2010 |
| Dengue virus could promote the expression of PGIS mRNA in HUVEC and increase the level of PGI(2), which may increase the vascular permeability. | [Effects of Dengue virus infection on PGIS expression and PGI2 secretion of human vascular endothelial cells].
Jiang ZY, Xiao R. | 01/21/2010 |
| The CC genotype and C allele of the prostacyclin synthase gene might be a risk factor of MI in Uigur population in Xinjiang. | [Association of polymorphism of the prostacyclin synthase gene with myocardial infarction in Uigur population of Xinjiang].
Xie X, Ma Y, Fu Z, Yang Y, Wang Y, Chen B, Liu F, Xie X, Ma Y, Fu Z, Yang Y, Wang Y, Chen B, Liu F. | 01/21/2010 |
| Characterization of the recombinant PGIS intermediates is reported in reactions with other peroxides, peracetic acid, and iodosylbenzene, providing a mechanistic model of a peroxidase reaction catalyzed by the class III cytochromes P450. | Characterization of the peroxidase mechanism upon reaction of prostacyclin synthase with peracetic acid. Identification of a tyrosyl radical intermediate.
Yeh HC, Gerfen GJ, Wang JS, Tsai AL, Wang LH., Free PMC Article | 01/21/2010 |
| Observational study and meta-analysis of gene-disease association. (HuGE Navigator) | Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.
Palmieri RT, Wilson MA, Iversen ES, Clyde MA, Calingaert B, Moorman PG, Poole C, Anderson AR, Anderson S, Anton-Culver H, Beesley J, Hogdall E, Brewster W, Carney ME, Chen X, Chenevix-Trench G, Chang-Claude J, Cunningham JM, Dicioccio RA, Doherty JA, Easton DF, Edlund CK, Gayther SA, Gentry-Maharaj A, Goode EL, Goodman MT, Kjaer SK, Hogdall CK, Hopkins MP, Jenison EL, Blaakaer J, Lurie G, McGuire V, Menon U, Moysich KB, Ness RB, Pearce CL, Pharoah PD, Pike MC, Ramus SJ, Rossing MA, Song H, Terada KY, Vandenberg D, Vierkant RA, Wang-Gohrke S, Webb PM, Whittemore AS, Wu AH, Ziogas A, Berchuck A, Schildkraut JM, Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer Group), Australian Ovarian Cancer Study Group., Free PMC Article | 01/11/2009 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | See all PubMed (2) articlesVariation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators. Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke.
Lemaitre RN, Rice K, Marciante K, Bis JC, Lumley TS, Wiggins KL, Smith NL, Heckbert SR, Psaty BM, Lemaitre RN, Rice K, Marciante K, Bis JC, Lumley TS, Wiggins KL, Smith NL, Heckbert SR, Psaty BM. | 01/11/2009 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | See all PubMed (2) articlesAssociation of polymorphisms of PTGS2 and CYP8A1 with myocardial infarction.
Xie X, Ma YT, Fu ZY, Yang YN, Ma X, Chen BD, Wang YH, Liu F, Xie X, Ma YT, Fu ZY, Yang YN, Ma X, Chen BD, Wang YH, Liu F. Assessment of the genetic component of hypertension.
Yamada Y, Matsuo H, Segawa T, Watanabe S, Kato K, Hibino T, Yokoi K, Ichihara S, Metoki N, Yoshida H, Satoh K, Nozawa Y. | 03/13/2008 |
| Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | See all PubMed (2) articlesIdentification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough.
Grilo A, Sáez-Rosas MP, Santos-Morano J, Sánchez E, Moreno-Rey C, Real LM, Ramírez-Lorca R, Sáez ME. Prostacyclin synthase and arachidonate 5-lipoxygenase polymorphisms and risk of colorectal polyps.
Poole EM, Bigler J, Whitton J, Sibert JG, Potter JD, Ulrich CM. | 03/13/2008 |
| Observational study of genotype prevalence. (HuGE Navigator) | Sequence analysis, frequency and ethnic distribution of VNTR polymorphism in the 5'-untranslated region of the human prostacyclin synthase gene (CYP8A1).
Chevalier D, Allorge D, Lo-Guidice JM, Cauffiez C, Lepetit C, Migot-Nabias F, Kenani A, Lhermitte M, Broly F. | 03/13/2008 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (19) articlesA Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC. Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease.
Roberts KE, Kawut SM, Krowka MJ, Brown RS Jr, Trotter JF, Shah V, Peter I, Tighiouart H, Mitra N, Handorf E, Knowles JA, Zacks S, Fallon MB, Pulmonary Vascular Complications of Liver Disease Study Group. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. [Haplotypes analysis of the prostacyclin synthase gene and myocardial infarction in Uigur population].
Ma YT, Xie X, Fu ZY, Yang YN, Ma X, Wang YH, Chen BD, Liu F. [Association of GLu461ALa polymorphism of prostacyclin synthase gene with myocardial infarction in Uigur population].
Xie X, Ma YT, Fu ZY, Yang YN, Ma X, Wang YH, Chen BD, Liu F. Determination of genetic predisposition to patent ductus arteriosus in preterm infants.
Dagle JM, Lepp NT, Cooper ME, Schaa KL, Kelsey KJ, Orr KL, Caprau D, Zimmerman CR, Steffen KM, Johnson KJ, Marazita ML, Murray JC. Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survival.
Abraham JE, Harrington P, Driver KE, Tyrer J, Easton DF, Dunning AM, Pharoah PD. A quantitative trait locus for SBP maps near KCNB1 and PTGIS in a population isolate.
Barbalić M, Narancić NS, Skarić-Jurić T, Salihović MP, Klarić IM, Lauc LB, Janićijević B, Farrall M, Rudan I, Campbell H, Wright AF, Hastie ND, Rudan P, Barbalić M, Narancić NS, Skarić-Jurić T, Salihović MP, Klarić IM, Lauc LB, Janićijević B, Farrall M, Rudan I, Campbell H, Wright AF, Hastie ND, Rudan P. Haplotype analysis of the CYP8A1 gene associated with myocardial infarction.
Xiang Xie, Ma YT, Fu ZY, Yang YN, Xiang Ma, Chen BD, Wang YH, Fen Liu. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.
Mavaddat N, Dunning AM, Ponder BA, Easton DF, Pharoah PD. [Association of polymorphism of the prostacyclin synthase gene with myocardial infarction in Uigur population of Xinjiang].
Xie X, Ma Y, Fu Z, Yang Y, Wang Y, Chen B, Liu F, Xie X, Ma Y, Fu Z, Yang Y, Wang Y, Chen B, Liu F. Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome.
Yoshida T, Kato K, Fujimaki T, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nishigaki Y, Tanaka M, Nozawa Y, Yamada Y. Functional polymorphism of the promoter region of the prostacyclin synthase gene and severity of RSV infection in hospitalized children.
Hashimoto K, Ishibashi K, Gebretsadik T, Hartert TV, Yamamoto A, Nakayama T, Ohashi K, Sakata H, Kawasaki Y, Katayose M, Sakuma H, Suzuki H, Hosoya M, Peebles RS Jr, Suzutani T. Polymorphism of the promoter region of prostacyclin synthase gene in chronic thromboembolic pulmonary hypertension.
Amano S, Tatsumi K, Tanabe N, Kasahara Y, Kurosu K, Takiguchi Y, Kasuya Y, Kimura S, Kuriyama T. Haplotype analysis of the prostacyclin synthase gene and essential hypertension.
Nakayama T, Soma M, Haketa A, Aoi N, Kosuge K, Sato M, Kanmatsuse K, Kokubun S. Association of a novel single nucleotide polymorphism of the prostacyclin synthase gene with myocardial infarction.
Nakayama T, Soma M, Saito S, Honye J, Yajima J, Rahmutula D, Kaneko Y, Sato M, Uwabo J, Aoi N, Kosuge K, Kunimoto M, Kanmatsuse K, Kokubun S. Association study between a novel single nucleotide polymorphism of the promoter region of the prostacyclin synthase gene and essential hypertension.
Nakayama T, Soma M, Rahmutula D, Tobe H, Sato M, Uwabo J, Aoi N, Kosuge K, Kunimoto M, Kanmatsuse K, Kokubun S, Nakayama T, Soma M, Rahmutula D, Tobe H, Sato M, Uwabo J, Aoi N, Kosuge K, Kunimoto M, Kanmatsuse K, Kokubun S. Polymorphism of the promoter region of prostacyclin synthase gene is not related to essential hypertension.
Nakayama T, Soma M, Takahashi Y, Rehemudula D, Tobe H, Sato M, Uwabo J, Kunimoto M, Izumi Y, Kanmatsuse K. Association of 5' upstream promoter region of prostacyclin synthase gene variant with cerebral infarction.
Nakayama T, Soma M, Rehemudula D, Takahashi Y, Tobe H, Satoh M, Uwabo J, Kunimoto M, Kanmatsuse K. | 03/13/2008 |
| These studies have provided the structural information for the interaction of the PGIS with its substrate mimic. | Characterization of the substrate mimic bound to engineered prostacyclin synthase in solution using high-resolution NMR spectroscopy and mutagenesis: implication of the molecular mechanism in biosynthesis of prostacyclin.
Ruan KH, Wu J, Cervantes V. | 01/21/2010 |
| Adenovirus PGIS gene transfer reduced PPAR delta expression and inhibited neointimal formation after balloon injury in accordance with the reduction in the phosphorylation of p38 MAPK | Prostacyclin synthase gene transfer inhibits neointimal formation by suppressing PPAR delta expression.
Imai H, Numaguchi Y, Ishii M, Kubota R, Yokouchi K, Ogawa Y, Kondo T, Okumura K, Murohara T. | 01/21/2010 |
| An intramuscular injection of AAV-PGIS prevents monocrotaline-pulmonary arterial hypertension in rats and provides a new therapeutic alternative for preventing pulmonary arterial hypertension in humans. | Adenoassociated virus-mediated prostacyclin synthase expression prevents pulmonary arterial hypertension in rats.
Ito T, Okada T, Mimuro J, Miyashita H, Uchibori R, Urabe M, Mizukami H, Kume A, Takahashi M, Ikeda U, Sakata Y, Shimada K, Ozawa K. | 01/21/2010 |
| Association study between a novel single nucleotide polymorphism of the promoter region of the prostacyclin synthase gene and essential hypertension. | Association study between a novel single nucleotide polymorphism of the promoter region of the prostacyclin synthase gene and essential hypertension.
Nakayama T, Soma M, Rahmutula D, Tobe H, Sato M, Uwabo J, Aoi N, Kosuge K, Kunimoto M, Kanmatsuse K, Kokubun S, Nakayama T, Soma M, Rahmutula D, Tobe H, Sato M, Uwabo J, Aoi N, Kosuge K, Kunimoto M, Kanmatsuse K, Kokubun S. | 01/21/2010 |
| the PGIS gene has a splicing mutation in familial hypertension | Splicing mutation of the prostacyclin synthase gene in a family associated with hypertension.
Nakayama T, Soma M, Watanabe Y, Hasimu B, Sato M, Aoi N, Kosuge K, Kanmatsuse K, Kokubun S, Marrow JD, Oates JA. | 01/21/2010 |
| Epigenetic inactivation of the PTGIS gene is a recurrent alteration in colorectal carcinogenesis | Hypermethylation of the prostacyclin synthase (PTGIS) promoter is a frequent event in colorectal cancer and associated with aneuploidy.
Frigola J, Muñoz M, Clark SJ, Moreno V, Capellà G, Peinado MA. | 01/21/2010 |
| effect of overexpression of this enzyme transfected into vascular smooth muscle cells in rats | Effects of overexpression of prostacyclin synthase in vascular smooth muscle cells.
Yokoyama C, Todaka T, Yanamoto H, Hatae T, Hara S, Shimonishi M, Ohkawara S, Wada M, Tanabe T. | 01/21/2010 |
| The two major genetic loci Pgis1 and Pgis2 of murine spondylitis are homologous to chromosome regions in human genome, which control ankylosing spondylitis in human patients. | Two major interacting chromosome loci control disease susceptibility in murine model of spondyloarthropathy.
Végvári A, Szabó Z, Szántó S, Nesterovitch AB, Mikecz K, Glant TT, Adarichev VA. | 01/21/2010 |
| NMR and circular dichroism solution structure of microsomal PGIS | Solution structure and topology of the N-terminal membrane anchor domain of a microsomal cytochrome P450: prostaglandin I2 synthase.
Ruan KH, So SP, Zheng W, Wu J, Li D, Kung J., Free PMC Article | 01/21/2010 |
| gestational age decrease in the inhibitory prostaglandin I2 synthase is consistent with lessening of its influence in myometrium at the time of labor | Expression of prostaglandin I(2) synthase, but not prostaglandin E synthase, changes in myometrium of women at term pregnancy.
Giannoulias D, Alfaidy N, Holloway AC, Gibb W, Sun M, Lye SJ, Challis JR. | 01/21/2010 |