| SOX5 promoted epithelial-mesenchymal transition (EMT) by regulation of Snail. | SOX5 promotes epithelial-mesenchymal transition in osteosarcoma via regulation of Snail.
Zhang D, Liu S. | 09/2/2017 |
| Short-SOX5 regulates transcription of human SPAG16L gene via directly binding to the promoter of SPAG16L. | Transcriptional regulation of human sperm-associated antigen 16 gene by S-SOX5.
Zhang L, Liu Y, Li W, Zhang Q, Li Y, Liu J, Min J, Shuang C, Song S, Zhang Z., Free PMC Article | 08/26/2017 |
| results suggest that lnc-Sox5, which was stabilized by HuR, could regulate carcinogenesis of tongue cancer and may serve as a predicted target for tongue carcinoma therapies | HuR Stabilizes lnc-Sox5 mRNA to Promote Tongue Carcinogenesis.
Wang L, Ye S, Wang J, Gu Z, Zhang Y, Zhang C, Ma X. | 06/3/2017 |
| Collectively, these findings indicate that SOX5 is a novel candidate gene for Alzheimer's disease(AD) with an important role in neuronal function. The genetic findings warrant further studies to identify and characterize SOX5 variants that confer risk for AD, amyotrophic lateral sclerosis and intellectual disability. | Silencing of the Drosophila ortholog of SOX5 leads to abnormal neuronal development and behavioral impairment.
Li A, Hooli B, Mullin K, Tate RE, Bubnys A, Kirchner R, Chapman B, Hofmann O, Hide W, Tanzi RE., Free PMC Article | 05/20/2017 |
| The results of the present study suggest a role for SOX5 in the molecular pathogenesis of FL. | Identification of the SOX5 gene as a novel IGH-involved translocation partner in BCL2-negative follicular lymphoma with t(12;14)(p12.2;q32).
Shiseki M, Masuda A, Yoshinaga K, Mori N, Okada M, Motoji T, Tanaka J. | 10/8/2016 |
| SOX5 has a strong inhibitory effect on MITF expression and seems to have a decisive clinical impact on melanoma during tumor progression. | SOX5 is involved in balanced MITF regulation in human melanoma cells.
Kordaß T, Weber CE, Oswald M, Ast V, Bernhardt M, Novak D, Utikal J, Eichmüller SB, König R., Free PMC Article | 10/1/2016 |
| Our results indicate for the first time that SOX5 is a novel regulator of epithelial-mesenchymal transition in hepatocellular carcinoma | SOX5 promotes epithelial-mesenchymal transition and cell invasion via regulation of Twist1 in hepatocellular carcinoma.
Wang D, Han S, Wang X, Peng R, Li X. | 10/17/2015 |
| Sox5-PAX5 fusion transcript is associated with B-cell precursor acute lymphoblastic leukemia. | Three novel fusion transcripts of the paired box 5 gene in B-cell precursor acute lymphoblastic leukemia.
Fazio G, Daniele G, Cazzaniga V, Impera L, Severgnini M, Iacobucci I, Galbiati M, Leszl A, Cifola I, De Bellis G, Bresciani P, Martinelli G, Basso G, Biondi A, Storlazzi CT, Cazzaniga G., Free PMC Article | 10/17/2015 |
| These findings describe for the first time a functional role of SOX5 during late B cell development reducing the proliferative capacity and thus potentially affecting the differentiation of B cells. | High levels of SOX5 decrease proliferative capacity of human B cells, but permit plasmablast differentiation.
Rakhmanov M, Sic H, Kienzler AK, Fischer B, Rizzi M, Seidl M, Melkaoui K, Unger S, Moehle L, Schmit NE, Deshmukh SD, Ayata CK, Schuh W, Zhang Z, Cosset FL, Verhoeyen E, Peter HH, Voll RE, Salzer U, Eibel H, Warnatz K, Rakhmanov M, Sic H, Kienzler AK, Fischer B, Rizzi M, Seidl M, Melkaoui K, Unger S, Moehle L, Schmit NE, Deshmukh SD, Ayata CK, Schuh W, Zhang Z, Cosset FL, Verhoeyen E, Peter HH, Voll RE, Salzer U, Eibel H, Warnatz K., Free PMC Articles: PMC4063782, PMC4063782 | 03/21/2015 |
| High Sox5 expression is associated with pituitary tumor. | MiR-132, miR-15a and miR-16 synergistically inhibit pituitary tumor cell proliferation, invasion and migration by targeting Sox5.
Renjie W, Haiqian L. | 03/7/2015 |
| detection of SOX5 polymorphism in nonobstructive azoospermia contributing to predicting males at high risk of disease in Han Chinese population | Association study between polymorphisms of PRMT6, PEX10, SOX5, and nonobstructive azoospermia in the Han Chinese population.
Zou S, Li Z, Wang Y, Chen T, Song P, Chen J, He X, Xu P, Liang M, Luo K, Zhu X, Tian E, Du Q, Wen Z, Li Z, Wang M, Sha Y, Cao Y, Shi Y, Hu H. | 03/7/2015 |
| Sox5 and Sox9 cause a significant increase in transactivation of the Catsper1 promoter. | The transcription factors Sox5 and Sox9 regulate Catsper1 gene expression.
Mata-Rocha M, Hernández-Sánchez J, Guarneros G, de la Chesnaye E, Sánchez-Tusié AA, Treviño CL, Felix R, Oviedo N. | 11/22/2014 |
| Identified two new splice variants of SOX5 in human B cells, encoding the known L-SOX5B isoform and a new shorter isoform L-SOX5F. SOX5 limits the proliferative capacity of human primary B lymphocytes and potentially affects the differentiation of human B cells during the germinal center responses. | High levels of SOX5 decrease proliferative capacity of human B cells, but permit plasmablast differentiation.
Rakhmanov M, Sic H, Kienzler AK, Fischer B, Rizzi M, Seidl M, Melkaoui K, Unger S, Moehle L, Schmit NE, Deshmukh SD, Ayata CK, Schuh W, Zhang Z, Cosset FL, Verhoeyen E, Peter HH, Voll RE, Salzer U, Eibel H, Warnatz K, Rakhmanov M, Sic H, Kienzler AK, Fischer B, Rizzi M, Seidl M, Melkaoui K, Unger S, Moehle L, Schmit NE, Deshmukh SD, Ayata CK, Schuh W, Zhang Z, Cosset FL, Verhoeyen E, Peter HH, Voll RE, Salzer U, Eibel H, Warnatz K., Free PMC Articles: PMC4063782, PMC4063782 | 07/30/2014 |
| depletion of Sox5 in breast cancer cells caused a dramatic decrease in Twist1 and chromosome immunoprecipitation assay showed that Sox5 can bind directly to the Twist1 promoter, suggesting that Sox5 transactivates Twist1 expression | Sox5 induces epithelial to mesenchymal transition by transactivation of Twist1.
Pei XH, Lv XQ, Li HX. | 06/14/2014 |
| Sox5 regulates the proliferation of malignant B cells. | Expression and function of a novel isoform of Sox5 in malignant B cells.
Edwards SK, Desai A, Liu Y, Moore CR, Xie P., Free PMC Article | 04/26/2014 |
| Two cases of 12p12.1 deletion involving SOX5 present with dysmorphic features and developmental delay. | Deletion 12p12 involving SOX5 in two children with developmental delay and dysmorphic features.
Lee RW, Bodurtha J, Cohen J, Fatemi A, Batista D. | 12/21/2013 |
| Our findings indicate that haploinsufficiency of SOX5 is a cause of intellectual disability without any striking physical anomalies. | Haploinsufficiency of SOX5, a member of the SOX (SRY-related HMG-box) family of transcription factors is a cause of intellectual disability.
Schanze I, Schanze D, Bacino CA, Douzgou S, Kerr B, Zenker M. | 07/20/2013 |
| L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity | L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity.
Yamashita S, Miyaki S, Kato Y, Yokoyama S, Sato T, Barrionuevo F, Akiyama H, Scherer G, Takada S, Asahara H., Free PMC Article | 09/22/2012 |
| MiR-194 regulates chondrogenic differentiation of adipose-derived stem cells by targeting Sox5 | MiR-194 regulates chondrogenic differentiation of human adipose-derived stem cells by targeting Sox5.
Xu J, Kang Y, Liao WM, Yu L., Free PMC Article | 07/28/2012 |
| Haploinsufficiency of SOX5 at 12p12.1 is associated with developmental delays with prominent language delay, behavior problems, and mild dysmorphic features | Haploinsufficiency of SOX5 at 12p12.1 is associated with developmental delays with prominent language delay, behavior problems, and mild dysmorphic features.
Lamb AN, Rosenfeld JA, Neill NJ, Talkowski ME, Blumenthal I, Girirajan S, Keelean-Fuller D, Fan Z, Pouncey J, Stevens C, Mackay-Loder L, Terespolsky D, Bader PI, Rosenbaum K, Vallee SE, Moeschler JB, Ladda R, Sell S, Martin J, Ryan S, Jones MC, Moran R, Shealy A, Madan-Khetarpal S, McConnell J, Surti U, Delahaye A, Heron-Longe B, Pipiras E, Benzacken B, Passemard S, Verloes A, Isidor B, Le Caignec C, Glew GM, Opheim KE, Descartes M, Eichler EE, Morton CC, Gusella JF, Schultz RA, Ballif BC, Shaffer LG., Free PMC Article | 07/14/2012 |
| SOX trio gene and protein decreased with advancement of osteoarthritis in human articular cartilage. | SOX trio decrease in the articular cartilage with the advancement of osteoarthritis.
Lee JS, Im GI. | 03/10/2012 |
| Genetic variation in the transcription factor SOX5 is associated with COPD susceptibility | SOX5 is a candidate gene for chronic obstructive pulmonary disease susceptibility and is necessary for lung development.
Hersh CP, Silverman EK, Gascon J, Bhattacharya S, Klanderman BJ, Litonjua AA, Lefebvre V, Sparrow D, Reilly JJ, Anderson WH, Lomas DA, Mariani TJ., Free PMC Article | 08/20/2011 |
| identified SOX5 and SOX6 as the first two SHOX-interacting proteins and have shown that this interaction regulates aggrecan expression, an essential factor in chondrogenesis and skeletal development. | SHOX interacts with the chondrogenic transcription factors SOX5 and SOX6 to activate the aggrecan enhancer.
Aza-Carmona M, Shears DJ, Yuste-Checa P, Barca-Tierno V, Hisado-Oliva A, Belinchón A, Benito-Sanz S, Rodríguez JI, Argente J, Campos-Barros A, Scambler PJ, Heath KE. | 07/23/2011 |
| SPAG6 is a S-SOX5 target gene, indicating a key role for S-SOX5 in the formation and function of motile cilia. | Transcriptional regulation of an axonemal central apparatus gene, sperm-associated antigen 6, by a SRY-related high mobility group transcription factor, S-SOX5.
Kiselak EA, Shen X, Song J, Gude DR, Wang J, Brody SL, Strauss JF 3rd, Zhang Z., Free PMC Article | 10/30/2010 |
| Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator) | Genome-wide association analysis identifies multiple loci related to resting heart rate.
Eijgelsheim M, Newton-Cheh C, Sotoodehnia N, de Bakker PI, Müller M, Morrison AC, Smith AV, Isaacs A, Sanna S, Dörr M, Navarro P, Fuchsberger C, Nolte IM, de Geus EJ, Estrada K, Hwang SJ, Bis JC, Rückert IM, Alonso A, Launer LJ, Hottenga JJ, Rivadeneira F, Noseworthy PA, Rice KM, Perz S, Arking DE, Spector TD, Kors JA, Aulchenko YS, Tarasov KV, Homuth G, Wild SH, Marroni F, Gieger C, Licht CM, Prineas RJ, Hofman A, Rotter JI, Hicks AA, Ernst F, Najjar SS, Wright AF, Peters A, Fox ER, Oostra BA, Kroemer HK, Couper D, Völzke H, Campbell H, Meitinger T, Uda M, Witteman JC, Psaty BM, Wichmann HE, Harris TB, Kääb S, Siscovick DS, Jamshidi Y, Uitterlinden AG, Folsom AR, Larson MG, Wilson JF, Penninx BW, Snieder H, Pramstaller PP, van Duijn CM, Lakatta EG, Felix SB, Gudnason V, Pfeufer A, Heckbert SR, Stricker BH, Boerwinkle E, O'Donnell CJ., Free PMC Article | 09/15/2010 |