| Hepatic Regulator of G Protein Signaling 5 Ameliorates Nonalcoholic Fatty Liver Disease by Suppressing Transforming Growth Factor Beta-Activated Kinase 1-c-Jun-N-Terminal Kinase/p38 Signaling. | Hepatic Regulator of G Protein Signaling 5 Ameliorates Nonalcoholic Fatty Liver Disease by Suppressing Transforming Growth Factor Beta-Activated Kinase 1-c-Jun-N-Terminal Kinase/p38 Signaling.
Wang J, Ma J, Nie H, Zhang XJ, Zhang P, She ZG, Li H, Ji YX, Cai J. | 06/19/2021 |
| A novel variant in MAP3K7 associated with an expanded cardiospondylocarpofacial syndrome phenotype. | A novel variant in MAP3K7 associated with an expanded cardiospondylocarpofacial syndrome phenotype.
AbuBakr F, Jeffries L, Ji W, McGrath JM, Lakhani SA., Free PMC Article | 05/29/2021 |
| Long non-coding RNA CCDC144NL-AS1 sponges miR-143-3p and regulates MAP3K7 by acting as a competing endogenous RNA in gastric cancer. | Long non-coding RNA CCDC144NL-AS1 sponges miR-143-3p and regulates MAP3K7 by acting as a competing endogenous RNA in gastric cancer.
Fan H, Ge Y, Ma X, Li Z, Shi L, Lin L, Xiao J, Chen W, Ni P, Yang L, Xu Z., Free PMC Article | 04/17/2021 |
| TAK1 lessens the activity of the paracaspase MALT1 during T cell receptor signaling. | TAK1 lessens the activity of the paracaspase MALT1 during T cell receptor signaling.
Nicolau CA, Gavard J, Bidère N. | 01/9/2021 |
| Modulating TAK1 Expression Inhibits YAP and TAZ Oncogenic Functions in Pancreatic Cancer. | Modulating TAK1 Expression Inhibits YAP and TAZ Oncogenic Functions in Pancreatic Cancer.
Santoro R, Zanotto M, Simionato F, Zecchetto C, Merz V, Cavallini C, Piro G, Sabbadini F, Boschi F, Scarpa A, Melisi D. | 12/12/2020 |
| Cytokine Production and NET Formation by Monosodium Urate-Activated Human Neutrophils Involves Early and Late Events, and Requires Upstream TAK1 and Syk. | Cytokine Production and NET Formation by Monosodium Urate-Activated Human Neutrophils Involves Early and Late Events, and Requires Upstream TAK1 and Syk.
Tatsiy O, Mayer TZ, de Carvalho Oliveira V, Sylvain-Prévost S, Isabel M, Dubois CM, McDonald PP., Free PMC Article | 12/5/2020 |
| SHARPIN overexpression promotes TAK1 expression and activates JNKs and NF-kappaB pathway in Mycosis Fungoides. | SHARPIN overexpression promotes TAK1 expression and activates JNKs and NF-κB pathway in Mycosis Fungoides.
Chen B, Zheng Y, Zhu J, Liang Y. | 10/31/2020 |
| Insights into the molecular pathogenesis of cardiospondylocarpofacial syndrome: MAP3K7 c.737-7A > G variant alters the TGFbeta-mediated alpha-SMA cytoskeleton assembly and autophagy. | Insights into the molecular pathogenesis of cardiospondylocarpofacial syndrome: MAP3K7 c.737-7A > G variant alters the TGFβ-mediated α-SMA cytoskeleton assembly and autophagy.
Micale L, Morlino S, Biagini T, Carbone A, Fusco C, Ritelli M, Giambra V, Zoppi N, Nardella G, Notarangelo A, Schirizzi A, Mazzoccoli G, Grammatico P, Wade EM, Mazza T, Colombi M, Castori M. | 10/24/2020 |
| TAK1 regulates endothelial cell necroptosis and tumor metastasis. | TAK1 regulates endothelial cell necroptosis and tumor metastasis.
Yang L, Joseph S, Sun T, Hoffmann J, Thevissen S, Offermanns S, Strilic B., Free PMC Article | 10/3/2020 |
| TAK1 suppresses RIPK1-dependent cell death and is associated with disease progression in melanoma. | TAK1 suppresses RIPK1-dependent cell death and is associated with disease progression in melanoma.
Podder B, Guttà C, Rožanc J, Gerlach E, Feoktistova M, Panayotova-Dimitrova D, Alexopoulos LG, Leverkus M, Rehm M., Free PMC Article | 10/3/2020 |
| hese findings demonstrate that loss of MAP3K7 is a main contributing factor to drug response through disruption of HR in prostate cancer. | Loss of MAP3K7 Sensitizes Prostate Cancer Cells to CDK1/2 Inhibition and DNA Damage by Disrupting Homologous Recombination.
Washino S, Rider LC, Romero L, Jillson LK, Affandi T, Ohm AM, Lam ET, Reyland ME, Costello JC, Cramer SD., Free PMC Article | 07/18/2020 |
| TAK1 mRNA and protein levels were upregulated in renal cell carcinoma (RCC) tissues. TAK1 is a potential target gene of miR-486 in RCC cells. | Role of miR-486-5p in regulating renal cell carcinoma cell proliferation and apoptosis via TGF-β-activated kinase 1.
He Y, Liu J, Wang Y, Zhu X, Fan Z, Li C, Yin H, Liu Y. | 06/27/2020 |
| The authors showed that TAK1, MAP kinase kinase 4 (MKK4), and JNK were activated in 293T cells transfected with the NS1 gene of the H5N1 virus. | Role of TGF-β-activated kinase 1 (TAK1) activation in H5N1 influenza A virus-induced c-Jun terminal kinase activation and virus replication.
Sheng T, Sun Y, Sun J, Prinz RA, Peng D, Liu X, Xu X. | 06/13/2020 |
| This review highlights how TAK1 orchestrates regulation of energy homeostasis via AMPK and its emerging role in influencing mTORC1 pathway to regulate death or survival in tandem. [review] | TAK1 mediates convergence of cellular signals for death and survival.
Aashaq S, Batool A, Andrabi KI. | 04/25/2020 |
| HSP70 inhibition upregulates Egr-1 via TAK1, inducing apoptosis and restricting proliferation in Acute lymphoblastic leukemia cells. | Suppression of HSP70 inhibits the development of acute lymphoblastic leukemia via TAK1/Egr-1.
Guo D, Zhang A, Huang J, Suo M, Zhong Y, Liang Y. | 02/29/2020 |
| Sirt1 expression was decreased, and the decreased Sirt1 level was correlated with increased pro-flammatory cytokines and TAK1 phosphorylation in active TB patients. Our mechanistic experiments showed that Sirt1 direclty interacted with TAK1 and suppressed its activation. | Role of Sirt1 in innate immune mechanisms against Mycobacterium tuberculosis via the inhibition of TAK1 activation.
Yang H, Hu J, Chen YJ, Ge B. | 02/15/2020 |
| results strongly suggest that TAK1 activation leads to AMPK activation, which activates ULK1 by phosphorylating ULK1(S317) and suppressing mTOR activity and ULK1(S757) phosphorylation. | Activation of TGF-β-activated kinase 1 (TAK1) restricts Salmonella Typhimurium growth by inducing AMPK activation and autophagy.
Liu W, Jiang Y, Sun J, Geng S, Pan Z, Prinz RA, Wang C, Sun J, Jiao X, Xu X., Free PMC Article | 11/9/2019 |
| TAK1 up regulates the expression of BMP-2 at all concentration under the inhibition of p38 and JNK. | Effect of TAK1 on osteogenic differentiation of mesenchymal stem cells by regulating BMP-2 via Wnt/β-catenin and MAPK pathway.
Yang H, Guo Y, Wang D, Yang X, Ha C., Free PMC Article | 09/21/2019 |
| TAK1 as a potential biomarker and therapeutic target for CTCL therapy. | Novel phosphorylated TAK1 species with functional impact on NF-κB and β-catenin signaling in human Cutaneous T-cell lymphoma.
Gallardo F, Bertran J, López-Arribillaga E, González J, Menéndez S, Sánchez I, Colomo L, Iglesias M, Garrido M, Santamaría-Babí LF, Torres F, Pujol RM, Bigas A, Espinosa L., Free PMC Article | 06/15/2019 |
| USP8 interacted with transforming growth factorbetaactivated kinase1 (TAK1) and deubiquitinated the K63linked ubiquitination of TAK1. | Effect of deubiquitinase USP8 on hypoxia/reoxygenation‑induced inflammation by deubiquitination of TAK1 in renal tubular epithelial cells.
Zhang Y, Luo Y, Wang Y, Liu H, Yang Y, Wang Q. | 03/2/2019 |
| This study revealed that the recurrent deletion of MAP3K7/CASP8AP2 is associated with SIL-TAL1 fusions and a mature immunophenotype, but not with response to treatment and risk of relapse in pediatric T-cell acute lymphoblastic leukemia | MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-κB.
Cordas Dos Santos DM, Eilers J, Sosa Vizcaino A, Orlova E, Zimmermann M, Stanulla M, Schrappe M, Börner K, Grimm D, Muckenthaler MU, Kulozik AE, Kunz JB., Free PMC Article | 02/9/2019 |
| De novo splicing variant in MAP3K7 was identified in a patient with cardiospondylocarpofacial syndrome with features of hereditary connective tissue disorder. | A novel MAP3K7 splice mutation causes cardiospondylocarpofacial syndrome with features of hereditary connective tissue disorder.
Morlino S, Castori M, Dordoni C, Cinquina V, Santoro G, Grammatico P, Venturini M, Colombi M, Ritelli M., Free PMC Article | 12/29/2018 |
| TAK1 plays a central role in promoting triple-negative breast cancer cell adaptation to the lung microenvironment by facilitating positive feedback signaling mediated by P38. | TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis.
Iriondo O, Liu Y, Lee G, Elhodaky M, Jimenez C, Li L, Lang J, Wang P, Yu M., Free PMC Article | 12/22/2018 |
| In brief, TAK1 can function as direct AMPK upstream kinase in specific contexts and in response to a subset of TAK1 activating stimuli. Further research is needed to define the intricate signals that are conditional for TAK1 to phosphorylate and activate AMPKalpha at T172. [review] | Is TAK1 a Direct Upstream Kinase of AMPK?
Neumann D., Free PMC Article | 12/22/2018 |
| The expression of IL-6 gene and protein was significantly induced by IL-17F. IL-17F activated TAK1 and NF-kappaB in airway smooth muscle cells. | IL-17F induces IL-6 via TAK1-NFκB pathway in airway smooth muscle cells.
Nakajima M, Kawaguchi M, Ota K, Fujita J, Matsukura S, Huang SK, Morishima Y, Ishii Y, Satoh H, Sakamoto T, Hizawa N., Free PMC Article | 11/17/2018 |