| In the absence of any N-linked glycans, TEM8 fails to fold correctly and is recognized by the ER quality control machinery. | Differential dependence on N-glycosylation of anthrax toxin receptors CMG2 and TEM8.
Friebe S, Deuquet J, van der Goot FG., Free PMC Article | 03/19/2016 |
| These studies expand the allelic spectrum in this rare condition and potentially provide insight into the role of ANTXR1 in the regulation of the extracellular matrix. | Whole exome sequencing identifies three novel mutations in ANTXR1 in families with GAPO syndrome.
Bayram Y, Pehlivan D, Karaca E, Gambin T, Jhangiani SN, Erdin S, Gonzaga-Jauregui C, Wiszniewski W, Muzny D, Baylor-Hopkins Center for Mendelian Genomics, Elcioglu NH, Yildirim MS, Bozkurt B, Zamani AG, Boerwinkle E, Gibbs RA, Lupski JR., Free PMC Article | 04/25/2015 |
| TEM8-targeted siRNAs also offered significant protection against lethal toxin in human macrophage-like cells. | Targeted silencing of anthrax toxin receptors protects against anthrax toxins.
Arévalo MT, Navarro A, Arico CD, Li J, Alkhatib O, Chen S, Diaz-Arévalo D, Zeng M., Free PMC Article | 10/11/2014 |
| ANTXR2 is expressed by human uterine smooth muscle cell and appears important for normal human uterine smooth muscle cell viability, migration and contractility. | Anthrax toxin receptor 2 promotes human uterine smooth muscle cell viability, migration and contractility.
Vink JY, Charles-Horvath PC, Kitajewski JK, Reeves CV., Free PMC Article | 03/22/2014 |
| High ANTXR1 accelerates breast tumor growth and lung metastasis. | ANTXR1, a stem cell-enriched functional biomarker, connects collagen signaling to cancer stem-like cells and metastasis in breast cancer.
Chen D, Bhat-Nakshatri P, Goswami C, Badve S, Nakshatri H., Free PMC Article | 11/16/2013 |
| There is an attenuation of ANTXR1 expression post-infection which may be a protective mechanism that has evolved to prevent reinfection. | Exposure to anthrax toxin alters human leucocyte expression of anthrax toxin receptor 1.
Ingram RJ, Harris A, Ascough S, Metan G, Doganay M, Ballie L, Williamson ED, Dyson H, Robinson JH, Sriskandan S, Altmann DM., Free PMC Article | 08/10/2013 |
| Mutations affecting ANTXR1 function are responsible for GAPO syndrome's characteristic generalized defect in extracellular-matrix homeostasis. | Mutations in ANTXR1 cause GAPO syndrome.
Stránecký V, Hoischen A, Hartmannová H, Zaki MS, Chaudhary A, Zudaire E, Nosková L, Barešová V, Přistoupilová A, Hodaňová K, Sovová J, Hůlková H, Piherová L, Hehir-Kwa JY, de Silva D, Senanayake MP, Farrag S, Zeman J, Martásek P, Baxová A, Afifi HH, St Croix B, Brunner HG, Temtamy S, Kmoch S., Free PMC Article | 07/6/2013 |
| Two new splice variants, one encoding a membrane-bound form of the receptor and the other secreted, which we have designated V4 and V5 (the latter being the only variant expressed in the prostate). | Broad expression analysis of human ANTXR1/TEM8 transcripts reveals differential expression and novel splizce variants.
Vargas M, Karamsetty R, Leppla SH, Chaudry GJ., Free PMC Article | 05/4/2013 |
| An acidic region in the cytosolic tail of ANTXR1 decreases actin association, sending a signal that prevents binding of ANTXR1 to the protective antigen and providing evidence that cytoskeletal dynamics regulate ANTXR1 function. | Binding of filamentous actin to anthrax toxin receptor 1 decreases its association with protective antigen.
Garlick KM, Batty S, Mogridge J., Free PMC Article | 05/5/2012 |
| Disruption of Tem8 results in impaired growth of human tumor xenografts of diverse origin including melanoma, breast, colon, and lung cancer. | TEM8/ANTXR1 blockade inhibits pathological angiogenesis and potentiates tumoricidal responses against multiple cancer types.
Chaudhary A, Hilton MB, Seaman S, Haines DC, Stevenson S, Lemotte PK, Tschantz WR, Zhang XM, Saha S, Fleming T, St Croix B., Free PMC Article | 05/5/2012 |
| The copy number of CEA and TEM-8 mRNA, as detected by a real-time quantitative PCR, appears to be a promising marker for evaluating the risk of tumor spread. | Quantitative analysis of TEM-8 and CEA tumor markers indicating free tumor cells in the peripheral blood of colorectal cancer patients.
Raeisossadati R, Farshchian M, Ganji A, Tavassoli A, Velayati A, Dadkhah E, Chavoshi S, Mehrabi Bahar M, Memar B, Rajabi Mashhadi MT, Naseh H, Forghanifard MM, Moghbeli M, Moaven O, Abbaszadegan MR. | 01/14/2012 |
| postulate that the developmentally controlled expression of TEM8 modulates endothelial cell response to canonical Wnt signaling to regulate vessel patterning and density | Tumor endothelial marker 8 amplifies canonical Wnt signaling in blood vessels.
Verma K, Gu J, Werner E., Free PMC Article | 12/31/2011 |
| TEM8.1 expression in breast cancer cells confers a more aggressive, proangiogenic phenotype. | Tumor endothelial marker 8 overexpression in breast cancer cells enhances tumor growth and metastasis.
Opoku-Darko M, Yuen C, Gratton K, Sampson E, Bathe OF. | 12/31/2011 |
| TEM8 was expressed at a higher level in the stroma adjacent to the triple-negative breast cancer in all cases, with focal immunoreactive areas within the tumor. | Tumor endothelial marker 8 expression in triple-negative breast cancer.
Gutwein LG, Al-Quran SZ, Fernando S, Fletcher BS, Copeland EM, Grobmyer SR. | 11/26/2011 |
| studies reveal that TEM8 exists in different forms at the cell surface, a structure dependent on interactions with components of the actin cytoskeleton | The cell surface structure of tumor endothelial marker 8 (TEM8) is regulated by the actin cytoskeleton.
Yang MY, Chaudhary A, Seaman S, Dunty J, Stevens J, Elzarrad MK, Frankel AE, St Croix B., Free PMC Article | 05/7/2011 |
| Data show that the two different PA oligomers are equally stabilized by ANTXR interactions. | Anthrax toxin receptor drives protective antigen oligomerization and stabilizes the heptameric and octameric oligomer by a similar mechanism.
Kintzer AF, Sterling HJ, Tang II, Williams ER, Krantz BA., Free PMC Article | 04/30/2011 |
| Results describe the expression, purification and crystallization of human anthrax toxin receptor 1 vWA domain to 1.8 A resolution from a single crystal. | Crystallization and preliminary X-ray analysis of the vWA domain of human anthrax toxin receptor 1.
Cai C, Zhao Y, Tong X, Fu S, Li Y, Wu Y, Li X, Lou Z., Free PMC Article | 04/16/2011 |
| the crystal structure of the TEM8 extracellular vWA domain at 1.7 A resolution. | The structure of tumor endothelial marker 8 (TEM8) extracellular domain and implications for its receptor function for recognizing anthrax toxin.
Fu S, Tong X, Cai C, Zhao Y, Wu Y, Li Y, Xu J, Zhang XC, Xu L, Chen W, Rao Z., Free PMC Article | 02/26/2011 |
| actin was also found to be essential for efficient heptamerization of anthrax toxin PA, but only when bound to one of its 2 receptors, TEM8 | Endocytosis of the anthrax toxin is mediated by clathrin, actin and unconventional adaptors.
Abrami L, Bischofberger M, Kunz B, Groux R, van der Goot FG., Free PMC Article | 06/28/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.
Wheeler HE, Metter EJ, Tanaka T, Absher D, Higgins J, Zahn JM, Wilhelmy J, Davis RW, Singleton A, Myers RM, Ferrucci L, Kim SK., Free PMC Article | 12/2/2009 |
| TEM8 expression levels in DC-based therapeutic vaccines would allow the selection of a subgroup of patients who are most likely to benefit from therapeutic vaccination. | Tumor endothelial marker 8 expression levels in dendritic cell-based cancer vaccines are related to clinical outcome.
Venanzi FM, Petrini M, Fiammenghi L, Bolli E, Granato AM, Ridolfi L, Gabrielli F, Barucca A, Concetti A, Ridolfi R, Riccobon A., Free PMC Article | 01/21/2010 |
| ANTXR1 does not use an adaptor to bind the cytoskeleton. This peptide orders actin filaments into arrays, demonstrating an actin bundling activity that is novel for a membrane protein | Direct interaction between anthrax toxin receptor 1 and the actin cytoskeleton.
Garlick KM, Mogridge J., Free PMC Article | 01/21/2010 |
| This is the first demonstration that the ATR/TEM8 protein is highly expressed in epithelial cells, suggesting that the ATR/TEM8 expression pattern is highly relevant for understanding the pathogenesis of anthrax infection. | ATR/TEM8 is highly expressed in epithelial cells lining Bacillus anthracis' three sites of entry: implications for the pathogenesis of anthrax infection.
Bonuccelli G, Sotgia F, Frank PG, Williams TM, de Almeida CJ, Tanowitz HB, Scherer PE, Hotchkiss KA, Terman BI, Rollman B, Alileche A, Brojatsch J, Lisanti MP. | 01/21/2010 |
| Data show that cells expressing palmitoylation-defective mutant receptors are less sensitive to anthrax toxin due to a lower number of surface receptors as well as premature internalization of protective antigen without a requirement for heptamerization. | Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis.
Abrami L, Leppla SH, van der Goot FG., Free PMC Article | 01/21/2010 |
| Here we describe the cloning of the human PA receptor using a genetic complementation approach | Identification of the cellular receptor for anthrax toxin.
Bradley KA, Mogridge J, Mourez M, Collier RJ, Young JA. | 01/21/2010 |