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    RUNX2 RUNX family transcription factor 2 [ Homo sapiens (human) ]

    Gene ID: 860, updated on 5-May-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Histone H3K9 demethylase JMJD2B/KDM4B promotes osteogenic differentiation of bone marrow-derived mesenchymal stem cells by regulating H3K9me2 on RUNX2.

    Histone H3K9 demethylase JMJD2B/KDM4B promotes osteogenic differentiation of bone marrow-derived mesenchymal stem cells by regulating H3K9me2 on RUNX2.
    Kang P, Wu Z, Huang Y, Luo Z, Huo S, Chen Q., Free PMC Article

    02/13/2023
    Diminished arachidonate 5-lipoxygenase perturbs phase separation and transcriptional response of Runx2 to reverse pathological ventricular remodeling.

    Diminished arachidonate 5-lipoxygenase perturbs phase separation and transcriptional response of Runx2 to reverse pathological ventricular remodeling.
    Xie S, Chen M, Fang W, Liu S, Wu Q, Liu C, Xing Y, Shi W, Xu M, Zhang M, Chen S, Zeng X, Wang S, Deng W, Tang Q., Free PMC Article

    01/14/2023
    RUNX2 stabilization by long non-coding RNAs contributes to hypertrophic changes in human chondrocytes.

    RUNX2 stabilization by long non-coding RNAs contributes to hypertrophic changes in human chondrocytes.
    Yoon DS, Kim EJ, Cho S, Jung S, Lee KM, Park KH, Lee JW, Kim SH., Free PMC Article

    01/11/2023
    YTHDF2-mediated FGF14-AS2 decay promotes osteolytic metastasis of breast cancer by enhancing RUNX2 mRNA translation.

    YTHDF2-mediated FGF14-AS2 decay promotes osteolytic metastasis of breast cancer by enhancing RUNX2 mRNA translation.
    Zhang M, Wang J, Jin Y, Zheng Q, Xing M, Tang Y, Ma Y, Li L, Yao B, Wu H, Ma C., Free PMC Article

    12/17/2022
    LncKCNQ1OT1 Promotes the Odontoblastic Differentiation of Dental Pulp Stem Cells via Regulating hsa-miR-153-3p/RUNX2 Axis.

    LncKCNQ1OT1 Promotes the Odontoblastic Differentiation of Dental Pulp Stem Cells via Regulating hsa-miR-153-3p/RUNX2 Axis.
    Lu X, Zhang J, Lu Y, Xing J, Lian M, Feng G, Huang D, Wang C, Shen N, Feng X., Free PMC Article

    11/19/2022
    RUNX2 recruits the NuRD(MTA1)/CRL4B complex to promote breast cancer progression and bone metastasis.

    RUNX2 recruits the NuRD(MTA1)/CRL4B complex to promote breast cancer progression and bone metastasis.
    Yin X, Teng X, Ma T, Yang T, Zhang J, Huo M, Liu W, Yang Y, Yuan B, Yu H, Huang W, Wang Y., Free PMC Article

    11/5/2022
    Runx2 and Nell-1 in dental follicle progenitor cells regulate bone remodeling and tooth eruption.

    Runx2 and Nell-1 in dental follicle progenitor cells regulate bone remodeling and tooth eruption.
    Zeng L, He H, Sun M, Gong X, Zhou M, Hong Y, Wu Y, Chen X, Chen Q., Free PMC Article

    10/15/2022
    RUNX2 Regulates Osteoblast Differentiation via the BMP4 Signaling Pathway.

    RUNX2 Regulates Osteoblast Differentiation via the BMP4 Signaling Pathway.
    Liu DD, Zhang CY, Liu Y, Li J, Wang YX, Zheng SG.

    08/27/2022
    A Novel 90-kbp Deletion of RUNX2 Associated with Cleidocranial Dysplasia.

    A Novel 90-kbp Deletion of RUNX2 Associated with Cleidocranial Dysplasia.
    Zhang Y, Duan X., Free PMC Article

    08/6/2022
    Fibroblast-like Synoviocytes-derived Exosomal PCGEM1 Accelerates IL-1beta-induced Apoptosis and Cartilage Matrix Degradation by miR-142-5p/RUNX2 in Chondrocytes.

    Fibroblast-like Synoviocytes-derived Exosomal PCGEM1 Accelerates IL-1β-induced Apoptosis and Cartilage Matrix Degradation by miR-142-5p/RUNX2 in Chondrocytes.
    Zeng G, Deng G, Xiao S, Li F.

    07/23/2022
    The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency.

    The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency.
    Wahlen S, Matthijssens F, Van Loocke W, Taveirne S, Kiekens L, Persyn E, Van Ammel E, De Vos Z, De Munter S, Matthys P, Van Nieuwerburgh F, Taghon T, Vandekerckhove B, Van Vlierberghe P, Leclercq G., Free PMC Article

    07/16/2022
    Cleidocranial dysplasia and novel RUNX2 variants: dental, craniofacial, and osseous manifestations.

    Cleidocranial dysplasia and novel RUNX2 variants: dental, craniofacial, and osseous manifestations.
    Thaweesapphithak S, Saengsin J, Kamolvisit W, Theerapanon T, Porntaveetus T, Shotelersuk V., Free PMC Article

    06/18/2022
    The Polymorphism at PLCB4 Promoter (rs6086746) Changes the Binding Affinity of RUNX2 and Affects Osteoporosis Susceptibility: An Analysis of Bioinformatics-Based Case-Control Study and Functional Validation.

    The Polymorphism at PLCB4 Promoter (rs6086746) Changes the Binding Affinity of RUNX2 and Affects Osteoporosis Susceptibility: An Analysis of Bioinformatics-Based Case-Control Study and Functional Validation.
    Tsai DJ, Fang WH, Wu LW, Tai MC, Kao CC, Huang SM, Chen WT, Hsiao PJ, Chiu CC, Su W, Wu CC, Su SL., Free PMC Article

    04/30/2022
    Epithelial microRNA-30a-3p targets RUNX2/HMGB1 axis to suppress airway eosinophilic inflammation in asthma.

    Epithelial microRNA-30a-3p targets RUNX2/HMGB1 axis to suppress airway eosinophilic inflammation in asthma.
    Wu W, Gao J, Chen D, Chen G, Feng Y, Chang C, Chen S, Yi L, Zhen G., Free PMC Article

    03/26/2022
    Regulation of Runx2 and Its Signaling Pathways by MicroRNAs in Breast Cancer Metastasis.

    Regulation of Runx2 and Its Signaling Pathways by MicroRNAs in Breast Cancer Metastasis.
    Pranavkrishna S, Sanjeev G, Akshaya RL, Rohini M, Selvamurugan N.

    03/19/2022
    miR-23b mediates TNF-alpha-Inhibited Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Targeting Runx2.

    miR-23b mediates TNF-α-Inhibited Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Targeting Runx2.
    Sun X, Li M, Ban J, Li Z., Free PMC Article

    03/12/2022
    Thrap3 promotes osteogenesis by inhibiting the degradation of Runx2.

    Thrap3 promotes osteogenesis by inhibiting the degradation of Runx2.
    Zhou L, Li H, Sun S, Zhang T, Yu Y, Xu L, Wang M.

    03/12/2022
    MiR-138-5p targets RUNX2 to inhibit osteogenic differentiation of aortic valve interstitial cells via Wnt/beta-catenin signaling pathway.

    MiR-138-5p targets RUNX2 to inhibit osteogenic differentiation of aortic valve interstitial cells via Wnt/β-catenin signaling pathway.
    Yan F, Huo Q, Zhang W, Wu T, Dilimulati D, Shi L., Free PMC Article

    03/5/2022
    MiR-30a-5p ameliorates LPS-induced inflammatory injury in human A549 cells and mice via targeting RUNX2.

    MiR-30a-5p ameliorates LPS-induced inflammatory injury in human A549 cells and mice via targeting RUNX2.
    Li P, Yao Y, Ma Y, Chen Y., Free PMC Article

    02/26/2022
    SIRT6 protects vascular smooth muscle cells from osteogenic transdifferentiation via Runx2 in chronic kidney disease.

    SIRT6 protects vascular smooth muscle cells from osteogenic transdifferentiation via Runx2 in chronic kidney disease.
    Li W, Feng W, Su X, Luo D, Li Z, Zhou Y, Zhu Y, Zhang M, Chen J, Liu B, Huang H., Free PMC Article

    02/19/2022
    Extracellular matrix stiffness controls VEGF165 secretion and neuroblastoma angiogenesis via the YAP/RUNX2/SRSF1 axis.

    Extracellular matrix stiffness controls VEGF(165) secretion and neuroblastoma angiogenesis via the YAP/RUNX2/SRSF1 axis.
    Bao M, Chen Y, Liu JT, Bao H, Wang WB, Qi YX, Lv F.

    02/19/2022
    Micro-RNA378a-3p Induces Apoptosis in Sarcomatoid Renal Cell Carcinoma and Regulates POLR2A and RUNX2 Expression.

    Micro-RNA378a-3p Induces Apoptosis in Sarcomatoid Renal Cell Carcinoma and Regulates POLR2A and RUNX2 Expression.
    Weng WH, Yu KJ, Jhan JW, Pang SN, Chiou YE, Pang ST.

    02/12/2022
    IRF2-mediated upregulation of lncRNA HHAS1 facilitates the osteogenic differentiation of bone marrow-derived mesenchymal stem cells by acting as a competing endogenous RNA.

    IRF2-mediated upregulation of lncRNA HHAS1 facilitates the osteogenic differentiation of bone marrow-derived mesenchymal stem cells by acting as a competing endogenous RNA.
    Ye G, Wang P, Xie Z, Li J, Zheng G, Liu W, Cao Q, Li M, Cen S, Li Z, Yu W, Wu Y, Shen H., Free PMC Article

    02/12/2022
    The roles of RUNX2 and osteoclasts in regulating expression of steroidogenic enzymes in castration-resistant prostate cancer cells.

    The roles of RUNX2 and osteoclasts in regulating expression of steroidogenic enzymes in castration-resistant prostate cancer cells.
    Huang J, Hagberg Thulin M, Damber JE, Welén K.

    01/29/2022
    Skeletal and molecular findings in 51 Cleidocranial dysplasia patients from Turkey.

    Skeletal and molecular findings in 51 Cleidocranial dysplasia patients from Turkey.
    Berkay EG, Elkanova L, Kalaycı T, Uludağ Alkaya D, Altunoğlu U, Cefle K, Mıhçı E, Nur B, Taşdelen E, Bayramoğlu Z, Karaman V, Toksoy G, Güneş N, Öztürk Ş, Palandüz Ş, Kayserili H, Tüysüz B, Uyguner ZO.

    01/15/2022