| Overexpression of cyclin A1 in FSHD indicates cell cycle dysregulation in FSHD and might contribute to clinical symptoms of this disease | Altered expression of cyclin A 1 in muscle of patients with facioscapulohumeral muscle dystrophy (FSHD-1).
Pakula A, Schneider J, Janke J, Zacharias U, Schulz H, Hübner N, Mähler A, Spuler A, Spuler S, Carlier P, Boschmann M., Free PMC Article | 05/17/2014 |
| Data indicate that induction of cyclin A1 overexpression in breast cancer cell line MCF-7 results in an enhanced invasiveness and a concomitant increase in vascular endothelial growth factor (VEGF) expression. | Cyclin A1 modulates the expression of vascular endothelial growth factor and promotes hormone-dependent growth and angiogenesis of breast cancer.
Syed Khaja AS, Dizeyi N, Kopparapu PK, Anagnostaki L, Härkönen P, Persson JL., Free PMC Article | 04/26/2014 |
| Nuclear FoxO3a promotes cell cycle progression by transcriptional upregulation of cyclin A1, promoting proliferation of human anaplastic thyroid carcinoma cells. | Foxo3a drives proliferation in anaplastic thyroid carcinoma through transcriptional regulation of cyclin A1: a paradigm shift that impacts current therapeutic strategies.
Marlow LA, von Roemeling CA, Cooper SJ, Zhang Y, Rohl SD, Arora S, Gonzales IM, Azorsa DO, Reddi HV, Tun HW, Döppler HR, Storz P, Smallridge RC, Copland JA., Free PMC Article | 04/27/2013 |
| These findings indicate the possible involvement of cyclins A and E in the pathogenesis of malignant melanoma. | Expression of cyclins A and E in melanocytic skin lesions and its correlation with some clinicopathologic features.
Alekseenko A, Wojas-Pelc A, Lis GJ, Wiśniowski Z, Czerwińska M, Niewiara Ł, Litwin JA. | 03/30/2013 |
| The organization of actin and cytokeratin cytoskeleton and the expression of TCTP, p53,cyclin A, RhoA and actin in HIO180 non-transformed ovarian epithelial cells, and OVCAR3 and SKOV3 ovarian epithelial cancer cells, was studied. | Inverse relationship between TCTP/RhoA and p53 /cyclin A/actin expression in ovarian cancer cells.
Kloc M, Tejpal N, Sidhu J, Ganachari M, Flores-Villanueva P, Jennings NB, Sood AK, Kubiak JZ, Ghobrial RM., Free PMC Article | 03/9/2013 |
| Cyclin A1 as overexpressed in induced lpuripotent stem cells cells compared to embryonic stem cells, suggesting that during reprogramming, cyclin A1 protein expression levels are not set correctly. | Cyclin A1 is essential for setting the pluripotent state and reducing tumorigenicity of induced pluripotent stem cells.
McLenachan S, Menchón C, Raya A, Consiglio A, Edel MJ., Free PMC Article | 03/2/2013 |
| Cyclin A1 is an important cell cycle regulator with age-related increased expression in tonsils of children. HPV16 induces overexpression of Cyclin A1 in HNSCC despite promoter methylation. | Cyclin A1 shows age-related expression in benign tonsils, HPV16-dependent overexpression in HNSCC and predicts lower recurrence rate in HNSCC independently of HPV16.
Weiss D, Koopmann M, Basel T, Rudack C., Free PMC Article | 12/22/2012 |
| Increased cyclin A1 in human bladder cancer cells may be regulated by activity of the USP2a deubiquitinase. | The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer.
Kim J, Kim WJ, Liu Z, Loda M, Freeman MR., Free PMC Article | 09/15/2012 |
| Cyclin-A1 is the first prototypic leukemia-testis-antigen to be expressed in acute myeloid leukemia leukemic stem cells. | Cyclin-A1 represents a new immunogenic targetable antigen expressed in acute myeloid leukemia stem cells with characteristics of a cancer-testis antigen.
Ochsenreither S, Majeti R, Schmitt T, Stirewalt D, Keilholz U, Loeb KR, Wood B, Choi YE, Bleakley M, Warren EH, Hudecek M, Akatsuka Y, Weissman IL, Greenberg PD., Free PMC Article | 08/18/2012 |
| Oxidized low density lipoprotein induces cyclin A synthesis in a process involving ERK, JNK and NFkappaB | Oxidized low density lipoprotein induces cyclin A synthesis. Involvement of ERK, JNK and NFkappaB.
Mazière C, Trécherel E, Ausseil J, Louandre C, Mazière JC. | 04/14/2012 |
| The integrated form of HPV might lead to CCNA1 promoter methylation in cervical cancer by some mechanisms. | Human papillomavirus's physical state and cyclin A1 promoter methylation in cervical cancer.
Yanatatsaneejit P, Mutirangura A, Kitkumthorn N. | 12/10/2011 |
| CCNA1 methylation may play a crucial role in HPV16-induced carcinogenesis of HNSCC independently of p53 | Promoter methylation of cyclin A1 is associated with human papillomavirus 16 induced head and neck squamous cell carcinoma independently of p53 mutation.
Weiss D, Basel T, Sachse F, Braeuninger A, Rudack C. | 09/24/2011 |
| anti-oncogenic role of miR-372 may be through control of cell growth and cell cycle progression by down-regulating the cell cycle genes CDK2 and cyclin A1 | MicroRNA-372 is down-regulated and targets cyclin-dependent kinase 2 (CDK2) and cyclin A1 in human cervical cancer, which may contribute to tumorigenesis.
Tian RQ, Wang XH, Hou LJ, Jia WH, Yang Q, Li YX, Liu M, Li X, Tang H., Free PMC Article | 09/17/2011 |
| mRNA expression of cyclin A1 in myelodysplastic syndrome patients is higher than in normal controls. | [Expression of cyclin A1 mRNA in patients with myelodysplastic syndrome and its clinical significance].
Jia JS, Xu SR. | 07/16/2011 |
| An increase in cyclin A1 expression was the only differentially expressed cell cycle regulatory gene found. Greater cyclin A protein levels were consistently observed in cells with active IRE1alpha and were dependent on XBP-1. | IRE1alpha controls cyclin A1 expression and promotes cell proliferation through XBP-1.
Thorpe JA, Schwarze SR., Free PMC Article | 11/27/2010 |
| revealed that KDM8 occupies the coding region of cyclin A1 and directly regulates transcription. | KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation.
Hsia DA, Tepper CG, Pochampalli MR, Hsia EY, Izumiya C, Huerta SB, Wright ME, Chen HW, Kung HJ, Izumiya Y., Free PMC Article | 07/5/2010 |
| These results indicate that HIV-1 integrase is required during uncoating for maintaining CypA-capsid protein interaction, which promotes optimal stability of the viral core. | Role of human immunodeficiency virus type 1 integrase in uncoating of the viral core.
Briones MS, Dobard CW, Chow SA., Free PMC Article | 05/10/2010 |
| Methylation of CCNA1 in cervical scrapings is strongly associated with high-grade cervical intraepithelial neoplasia and cervical cancer. | Methylation markers for CCNA1 and C13ORF18 are strongly associated with high-grade cervical intraepithelial neoplasia and cervical cancer in cervical scrapings.
Yang N, Eijsink JJ, Lendvai A, Volders HH, Klip H, Buikema HJ, van Hemel BM, Schuuring E, van der Zee AG, Wisman GB. | 02/1/2010 |
| Four point mutations, c.321T>C, IVS3 +32G>C, IVS5+38A>G and c.1158G>A, are not associated with spermatogenesis impairment. | Mutations of the cyclin A1 gene are not a common cause of male infertility.
Zhoucun A, Zhang S, Yang Y, Zhoucun A, Zhang S, Yang Y. | 01/21/2010 |
| Study shows that transcription corepressor CtBP2 directly binds acinus, which is regulated by nerve growth factor (NGF), inhibiting its stimulatory effect on cyclin A1, but not cyclin A2, expression in leukemia. | NGF inhibits human leukemia proliferation by downregulating cyclin A1 expression through promoting acinus/CtBP2 association.
Chan CB, Liu X, Jang SW, Hsu SI, Williams I, Kang S, Chen J, Ye K., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesMutations of the cyclin A1 gene are not a common cause of male infertility.
Zhoucun A, Zhang S, Yang Y, Zhoucun A, Zhang S, Yang Y. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.
Cunningham JM, Vierkant RA, Sellers TA, Phelan C, Rider DN, Liebow M, Schildkraut J, Berchuck A, Couch FJ, Wang X, Fridley BL, Ovarian Cancer Association Consortium, Gentry-Maharaj A, Menon U, Hogdall E, Kjaer S, Whittemore A, DiCioccio R, Song H, Gayther SA, Ramus SJ, Pharaoh PD, Goode EL. | 12/2/2009 |
| Results suggest that cyclin A1 protein is stabilized via post-transcriptional modification in response to apoptosis induced by staurosporine or TNFalpha. | Post-translational modification of cyclin A1 is associated with staurosporine and TNFalpha induced apoptosis in leukemic cells.
Ekberg J, Persson JL. | 01/21/2010 |
| The CCNA1, CCNB1, CCNB2, PRM1, and PRM2 messenger RNA transcript ratios were significantly decreased in patients with spermatogenic disorders. Transcript ratios in patients with successful sperm retrieval were higher than with failed sperm retrieval. | Cyclin and protamine as prognostic molecular marker for testicular sperm extraction in patients with azoospermia.
Haraguchi T, Ishikawa T, Yamaguchi K, Fujisawa M. | 01/21/2010 |
| Cyclin A1- and cyclin A2-containing CDK complexes were compared in vitro by determining kinetic constants and by examining the complexes for their ability to phosphorylate pRb and p53. | Distinct properties of cyclin-dependent kinase complexes containing cyclin A1 and cyclin A2.
Joshi AR, Jobanputra V, Lele KM, Wolgemuth DJ., Free PMC Article | 01/21/2010 |
| Cyclin A1 contributes to prostate cancer invasion by modulating the expression of MMPs and VEGF and by interacting with AR (androgen receptor). | Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis.
Wegiel B, Bjartell A, Tuomela J, Dizeyi N, Tinzl M, Helczynski L, Nilsson E, Otterbein LE, Härkönen P, Persson JL., Free PMC Article | 01/21/2010 |