| Results show that Depletion of CHD8 enhances HOXA2 expression and a loss of the WDR5/Ash2L/RbBP5 subcomplex. | Regulation of HOXA2 gene expression by the ATP-dependent chromatin remodeling enzyme CHD8.
Yates JA, Menon T, Thompson BA, Bochar DA. | 05/10/2010 |
| Ash2l and Saf-A are recruited to the inactive X chromosome at the onset of stable X inactivation. | The Trithorax group protein Ash2l and Saf-A are recruited to the inactive X chromosome at the onset of stable X inactivation.
Pullirsch D, Härtel R, Kishimoto H, Leeb M, Steiner G, Wutz A., Free PMC Article | 04/12/2010 |
| high dimethylation of histone H3 at lysine 4 expression is rare in hepatocellular carcinoma compared with other carcinomas, possibly due to complex epigenetic regulation involving Ash2 | H3K4 dimethylation in hepatocellular carcinoma is rare compared with other hepatobiliary and gastrointestinal carcinomas and correlates with expression of the methylase Ash2 and the demethylase LSD1.
Magerl C, Ellinger J, Braunschweig T, Kremmer E, Koch LK, Höller T, Büttner R, Lüscher B, Gütgemann I. | 02/22/2010 |
| The identified components revealed factors involved in histone methylation and cell cycle control and include Ash2L, RbBP5, WDR5, HCF-1, DBC-1, and EMSY. | Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation.
Garapaty S, Xu CF, Trojer P, Mahajan MA, Neubert TA, Samuels HH., Free PMC Article | 01/21/2010 |
| Although hASH2 expression at the mRNA level was not deregulated, hASH2 protein expression was increased in most human tumors and tumor cell lines. Knockdown of hASH2 inhibited tumor cell proliferation. These show hASH2 as a novel oncoprotein. | The human trithorax protein hASH2 functions as an oncoprotein.
Lüscher-Firzlaff J, Gawlista I, Vervoorts J, Kapelle K, Braunschweig T, Walsemann G, Rodgarkia-Schamberger C, Schuchlautz H, Dreschers S, Kremmer E, Lilischkis R, Cerni C, Wellmann A, Lüscher B. | 01/21/2010 |
| These findings offer insight into the molecular role of ASH2L, and by extension that of WDR5, in proper H3K4 trimethylation. | Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes.
Steward MM, Lee JS, O'Donovan A, Wyatt M, Bernstein BE, Shilatifard A. | 01/21/2010 |