| Molecular determinants of SR-B1-dependent Plasmodium sporozoite entry into hepatocytes. | Molecular determinants of SR-B1-dependent Plasmodium sporozoite entry into hepatocytes.
Langlois AC, Manzoni G, Vincensini L, Coppée R, Marinach C, Guérin M, Huby T, Carrière V, Cosset FL, Dreux M, Rubinstein E, Silvie O., Free PMC Article | 12/26/2020 |
| CETP, LIPC, and SCARB1 variants in individuals with extremely high high-density lipoprotein-cholesterol levels. | CETP, LIPC, and SCARB1 variants in individuals with extremely high high-density lipoprotein-cholesterol levels.
Lee CJ, Park MS, Kim M, Ann SJ, Lee J, Park S, Kang SM, Jang Y, Lee JH, Lee SH., Free PMC Article | 11/21/2020 |
| Identification of scavenger receptor BI as a potential screening candidate for congenital primary adrenal insufficiency in humans. | Identification of scavenger receptor BI as a potential screening candidate for congenital primary adrenal insufficiency in humans.
Hoekstra M. | 10/31/2020 |
| High SR-B1 expression is associated with metastatic Prostate Cancer. | Upregulation of Scavenger Receptor B1 Is Required for Steroidogenic and Nonsteroidogenic Cholesterol Metabolism in Prostate Cancer.
Gordon JA, Noble JW, Midha A, Derakhshan F, Wang G, Adomat HH, Tomlinson Guns ES, Lin YY, Ren S, Collins CC, Nelson PS, Morrissey C, Wasan KM, Cox ME., Free PMC Article | 04/11/2020 |
| one of the main functions of SR-B1 in the skin is to regulate ceramide levels and thereby maintain the barrier function of the skin, resulting in the protection of cutaneous tissues from outdoor insults | Involvement of cutaneous SR-B1 in skin lipid homeostasis.
Muresan XM, Narzt MS, Woodby B, Ferrara F, Gruber F, Valacchi G. | 02/29/2020 |
| SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis | SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis.
Huang L, Chambliss KL, Gao X, Yuhanna IS, Behling-Kelly E, Bergaya S, Ahmed M, Michaely P, Luby-Phelps K, Darehshouri A, Xu L, Fisher EA, Ge WP, Mineo C, Shaul PW., Free PMC Article | 02/8/2020 |
| key proline residues play an important role in SR-BI function by allowing for the efficient transport of cholesterol between cells and HDL. | Proline residues in scavenger receptor-BI's C-terminal region support efficient cholesterol transport.
Proudfoot SC, Sahoo D., Free PMC Article | 12/21/2019 |
| Three rare SCARB1 mutations, encoding p.G319V, p.V111M, and p.V32M (combined allelic frequency = 0.2%) associate with elevated levels of HDL-C, but do not associate with coronary artery disease. | Rare SCARB1 mutations associate with high-density lipoprotein cholesterol but not with coronary artery disease.
Helgadottir A, Sulem P, Thorgeirsson G, Gretarsdottir S, Thorleifsson G, Jensson BÖ, Arnadottir GA, Olafsson I, Eyjolfsson GI, Sigurdardottir O, Thorsteinsdottir U, Gudbjartsson DF, Holm H, Stefansson K., Free PMC Article | 12/7/2019 |
| the rs5888 SNP in the SCARB1 gene is associated with CAD; furthermore, the TT genotype is associated with a higher HDL-C concentration. | Association of rs5888 SNP in SCARB1 gene with coronary artery disease : Study of a Han Chinese population.
Xie L, Lv X, Sun Y, Tong Y, Zhang S, Deng Y. | 11/30/2019 |
| Rare P376L variant in the SR-BI gene associates with HDL dysfunction and risk of cardiovascular disease. | Rare P376L variant in the SR-BI gene associates with HDL dysfunction and risk of cardiovascular disease.
Samadi S, Farjami Z, Hosseini ZS, Ferns GA, Mohammadpour AH, Tayefi M, Fal-Soleiman H, Moohebati M, Ghayour-Mobarhan M, Esmaily H, Avan A. | 11/23/2019 |
| To characterize the molecular mechanism involved in the redox modulation of SRB1, its cellular levels were assessed in human alveolar epithelial cells after O3 exposure. The results demonstrated that O3 induced the loss of SRB1 protein levels. | Tropospheric ozone affects SRB1 levels via oxidative post-translational modifications in lung cells.
Sticozzi C, Pecorelli A, Romani A, Belmonte G, Cervellati F, Maioli E, Lila MA, Cervellati C, Valacchi G. | 09/21/2019 |
| Attenuated LRP1 function decreases ABCA1 and increases SR-B1 plasma membrane expression, which combined may explain reduced HDL-C levels in individuals with loss-of-function LRP1 variants. | Naturally Occurring Variants in LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Affect HDL (High-Density Lipoprotein) Metabolism Through ABCA1 (ATP-Binding Cassette A1) and SR-B1 (Scavenger Receptor Class B Type 1) in Humans.
Oldoni F, van Capelleveen JC, Dalila N, Wolters JC, Heeren J, Sinke RJ, Hui DY, Dallinga-Thie GM, Frikke-Schmidt R, Hovingh KG, van de Sluis B, Tybjærg-Hansen A, Kuivenhoven JA., Free PMC Article | 07/20/2019 |
| SCARB1 knockdown decreases MITF expression and extracellular vesicle release in melanoma cells. | Loss of SR-BI Down-Regulates MITF and Suppresses Extracellular Vesicle Release in Human Melanoma.
Kinslechner K, Schütz B, Pistek M, Rapolter P, Weitzenböck HP, Hundsberger H, Mikulits W, Grillari J, Röhrl C, Hengstschläger M, Stangl H, Mikula M., Free PMC Article | 06/8/2019 |
| miR-24 accelerates atherogenesis by repressing SR-BI-mediated selective lipid uptake from HDL-C. | MicroRNA-24 aggravates atherosclerosis by inhibiting selective lipid uptake from HDL cholesterol via the post-transcriptional repression of scavenger receptor class B type I.
Ren K, Zhu X, Zheng Z, Mo ZC, Peng XS, Zeng YZ, Ou HX, Zhang QH, Qi HZ, Zhao GJ, Yi GH. | 06/1/2019 |
| This study concluded that CD81 and SCARB1 SNPs may serve as powerful predictor factors for treatment responses in CHC patients, and this effect is correlated with serum lipoprotein and FBS levels. | Correlation of CD81 and SCARB1 polymorphisms on virological responses in Iranian patients with chronic hepatitis C virus genotype 1.
Nafari M, Irani S, Vaziri F, Gharibzadeh S, Sakhaee F, Khazeni M, Kalhor N, Jamnani FR, Siadat SD, Fateh A. | 06/1/2019 |
| High-density lipoprotein increases expression of SR-B1 in placental cells but also reduces uptake of transthyretin-thyroid hormone through the SR-B1 transporter. | Transthyretin uptake in placental cells is regulated by the high-density lipoprotein receptor, scavenger receptor class B member 1.
Landers KA, Li H, Mortimer RH, McLeod DSA, d'Emden MC, Richard K. | 05/11/2019 |
| Findings showed that the expression of hSR-B1 was significantly reduced on the surface of platelets from CAD patients with atherosclerotic disease, as compared with healthy controls (6/8% vs. 13/6%) (P < 0,001). | The expression of hSR-B1 on platelets of patients with coronary artery disease (CAD).
Hamidpour M, Bashash D, Nehzati P, Abbasalizadeh M, Nikoogoftar M, Hamidpour R. | 04/27/2019 |
| Results provide strong evidence for the association of rs10846744, which resides within an enhancer region, with Lp-PLA2 activity and evidence from a number of large genetic studies for association with cardiovascular disease events. | Lp-PLA2, scavenger receptor class B type I gene (SCARB1) rs10846744 variant, and cardiovascular disease.
Manichaikul A, Wang XQ, Li L, Erdmann J, Lettre G, Bis JC, Waterworth D, Cushman M, Jenny NS, Post WS, Palmas W, Tsai MY, Wallentin L, White H, Schunkert H, O'Donnell CJ, Herrington DM, Rich SS, O'Donoghue ML, Rodriguez A., Free PMC Article | 03/30/2019 |
| Results demonstrate that SR-BI is a highly expressed receptor in human metastatic melanoma and is crucial for the maintenance of the metastatic phenotype. | Malignant Phenotypes in Metastatic Melanoma are Governed by SR-BI and its Association with Glycosylation and STAT5 Activation.
Kinslechner K, Schörghofer D, Schütz B, Vallianou M, Wingelhofer B, Mikulits W, Röhrl C, Hengstschläger M, Moriggl R, Stangl H, Mikula M., Free PMC Article | 01/19/2019 |
| The data obtained showed that not only cigarette, but also the other environmental stressors reduced SR-B1 expression in epidermal cutaneous tissues and that this effect might be involved in impaired wound healing. | Modulation of cutaneous scavenger receptor B1 levels by exogenous stressors impairs "in vitro" wound closure.
Muresan XM, Sticozzi C, Belmonte G, Savelli V, Evelson P, Valacchi G. | 11/17/2018 |
| Findings suggested that polymorphism rs5888 had negative association with coronary heart disease, especially in male. [review] | SCARB1 rs5888 gene polymorphisms in coronary heart disease: A systematic review and a meta-analysis.
Ma R, Zhu X, Yan B. | 10/27/2018 |
| We demonstrate that 4F and Cl/NO2-HDL act on scavenger receptor type I (SR-B1) using human aorta endothelial cells (HAEC) and SR-B1 ((-/-)) mouse aortic endothelial cells. | Apolipoprotein A-1 mimetic peptide 4F promotes endothelial repairing and compromises reendothelialization impaired by oxidized HDL through SR-B1.
He D, Zhao M, Wu C, Zhang W, Niu C, Yu B, Jin J, Ji L, Willard B, Mathew AV, Chen YE, Pennathur S, Yin H, He Y, Pan B, Zheng L., Free PMC Article | 10/13/2018 |
| Our results demonstrate that SR-BI functions as an oncogene and promotes progression of clear cell renal cell carcinoma (ccRCC). SR-BI may serve as a potential prognostic biomarker and therapeutic target for ccRCC. | Up-regulation of SR-BI promotes progression and serves as a prognostic biomarker in clear cell renal cell carcinoma.
Xu GH, Lou N, Shi HC, Xu YC, Ruan HL, Xiao W, Liu L, Li X, Xiao HB, Qiu B, Bao L, Yuan CF, Zhou YL, Hu WJ, Chen K, Yang HM, Zhang XP., Free PMC Article | 08/18/2018 |
| SCARB1 gene polymorphisms may serve as a potential predictor of treatment responses in chronic hepatitis C patients receiving interferon-based therapy | Association of SCARB1 Gene Polymorphisms with Virological Response in Chronic Hepatitis C Patients Receiving Pegylated Interferon plus Ribavirin Therapy.
Hsu CS, Hsu SJ, Liu WL, Chen DS, Kao JH., Free PMC Article | 05/19/2018 |
| The S112F single amino acid mutation in SR-BI inhibited the infectivity of hepatitis C virus derived from cell culture in a cell culture model by downregulating the expression of the SR-BI protein. | Single amino acid mutation of SR-BI decreases infectivity of hepatitis C virus derived from cell culture in a cell culture model.
Gao R, Gao W, Xu G, Xu J, Ren H., Free PMC Article | 05/12/2018 |