| DC-10 represents a novel subset of tolerogenic dendritic cells, which secrete high levels of IL-10, express ILT4 and HLA-G, and have the specific function to induce Tr1 cells | Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway.
Gregori S, Tomasoni D, Pacciani V, Scirpoli M, Battaglia M, Magnani CF, Hauben E, Roncarolo MG. | 09/20/2010 |
| upregulated on antigen-presenting cells in response to Salmonella infection | The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infection.
Brown DP, Jones DC, Anderson KJ, Lapaque N, Buerki RA, Trowsdale J, Allen RL., Free PMC Article | 05/31/2010 |
| Low-tryptophan-conditioned dendritic cells acquire strong tolerogenic capacity associated with a significant increase in inhibitory receptors ILT3 and ILT4 and favor induction of CD4+CD25+Foxp3+ T cells with suppressive function. | Tryptophan deprivation induces inhibitory receptors ILT3 and ILT4 on dendritic cells favoring the induction of human CD4+CD25+ Foxp3+ T regulatory cells.
Brenk M, Scheler M, Koch S, Neumann J, Takikawa O, Häcker G, Bieber T, von Bubnoff D. | 01/21/2010 |
| crystals of the LILRB2/HLA-G complex belong to space group P3(1)21 (a=b=81.4 A, c=186.7 A, gamma=120 degrees). | Crystallization and preliminary X-ray analysis of the low-affinity complex between human leukocyte antigen-G (HLA-G) and leukocyte Ig-like receptor B2 (LILRB2).
Shiroishi M, Maenaka K. | 01/21/2010 |
| A significant association is observed between ILT4 dendritic cells in kidney transplants and donor age. | Changes in the expression of the immunoglobulin-like transcript 3 (ILT3) and ILT4 receptors in renal allograft recipients: effect of donor and recipient aging.
Benito MJ, Lopez-Hoyos M, Fernandez-Fresnedo G, Ruiz JC, Benito A, San Segundo D, Gomez-Alamillo C, Arias M. | 01/21/2010 |
| Membrane-associated ILT4 is a a novel receptor for CD1d antigen that inhibits CD1d-mediated immune responses by blocking the loading of lipid antigens such as alpha-galactosylceramide, consequently inhibiting natural killer (NK)T cell recognition. | Ig-like transcript 4 inhibits lipid antigen presentation through direct CD1d interaction.
Li D, Wang L, Yu L, Freundt EC, Jin B, Screaton GR, Xu XN., Free PMC Article | 01/21/2010 |
| The presence of LILRB1 in placental stromal cells and LILRB2 in vascular smooth muscle strongly suggest that HLA-G has novel functions in regulation of placental immunity, development and function of the extraembryonic vasculature. | Novel HLA-G-binding leukocyte immunoglobulin-like receptor (LILR) expression patterns in human placentas and umbilical cords.
McIntire RH, Sifers T, Platt JS, Ganacias KG, Langat DK, Hunt JS., Free PMC Article | 01/21/2010 |
| Triggering of ILT4 in vitro and in vivo by certain isoforms of HLA-G phosphorylates ILT4 receptor, recruits SHP-1 and SHP-2, up-regulates the expression of IL-6, and down-regulates the differentiation of DCs via the IL-6-STAT3 pathway. | Modulation of dendritic cell differentiation by HLA-G and ILT4 requires the IL-6--STAT3 signaling pathway.
Liang S, Ristich V, Arase H, Dausset J, Carosella ED, Horuzsko A., Free PMC Article | 01/21/2010 |
| our results suggest that both the nonfunctional LILRA3 alleles and the low-expressing LILRB2 alleles identified in our study have increased in Northeast Asians because of natural selection. | Evidence for natural selection on leukocyte immunoglobulin-like receptors for HLA class I in Northeast Asians.
Hirayasu K, Ohashi J, Tanaka H, Kashiwase K, Ogawa A, Takanashi M, Satake M, Jia GJ, Chimge NO, Sideltseva EW, Tokunaga K, Yabe T., Free PMC Article | 01/21/2010 |
| Progenitor mast cells expressed cell surface inhibitory LILRB2. Mature cord-blood-derived mast cells had detectable mRNA encoding multiple LILRs, none were expressed on the cell surface. | Differential expression of leukocyte immunoglobulin-like receptors on cord-blood-derived human mast cell progenitors and mature mast cells.
Tedla N, Lee CW, Borges L, Geczy CL, Arm JP. | 01/21/2010 |
| Tolerogenicity of professional and non-professional human APC, such as dendritic cells and endothelial cells, respectively is due to the upregulation of the inhibitory receptors ILT3 and ILT4. | Central role of ILT3 in the T suppressor cell cascade.
Suciu-Foca N, Cortesini R. | 01/21/2010 |
| Blocking HLA-G receptors ILT2 and ILT4 prevents HLA-G inhibitory effects, leading to the conclusion that that HLA-G acts mainly through these receptors. | Soluble HLA-G and HLA-G1 expressing antigen-presenting cells inhibit T-cell alloproliferation through ILT-2/ILT-4/FasL-mediated pathways.
Naji A, Durrbach A, Carosella ED, Rouas-Freiss N. | 01/21/2010 |
| report that ILT2 receptor, ILT3 receptor, ILT4 receptor, and KIR2DL4 receptor expression is up-regulated by HLA-G histocompatibility antigen in antigen-presenting cells, natural killer cells, and T cells | HLA-G up-regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells.
LeMaoult J, Zafaranloo K, Le Danff C, Carosella ED. | 01/21/2010 |
| subtle structural differences between LILRB family members cause the distinct binding specificities to various forms of HLA-G and other MHCIs, which may in turn regulate immune suppression | Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d).
Shiroishi M, Kuroki K, Rasubala L, Tsumoto K, Kumagai I, Kurimoto E, Kato K, Kohda D, Maenaka K., Free PMC Article | 01/21/2010 |
| Two single nucleotide polymorphisms of ILT4 were identified at positions 113 and 144 of domain 1, which is engaged in protein-protein interactions between APC and T cells. | Novel single nucleotide polymorphisms in the human immune inhibitory immunoglobulin-like T cell receptor type 4.
Papanikolaou NA, Vasilescu ER, Suciu-Foca N. | 01/21/2010 |
| constitutive cis binding between leukocyte immunoglobulin (Ig)-like receptor B2 or paired-Ig-like receptor B and major histocompatibility complex class I has an essential role in regulating allergic responses | Cis binding between inhibitory receptors and MHC class I can regulate mast cell activation.
Masuda A, Nakamura A, Maeda T, Sakamoto Y, Takai T., Free PMC Article | 01/21/2010 |
| inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G | Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G.
Shiroishi M, Tsumoto K, Amano K, Shirakihara Y, Colonna M, Braud VM, Allan DS, Makadzange A, Rowland-Jones S, Willcox B, Jones EY, van der Merwe PA, Kumagai I, Maenaka K., Free PMC Article | 01/21/2010 |