| Studies indicate that in the cytoplasm, PER3 protein heterodimerizes with PER1, PER2, CRY1, and CRY2 proteins and enters into the nucleus, resulting in repression of CLOCK-BMAL1-mediated transcription. | Analysis of the molecular pathophysiology of sleep disorders relevant to a disturbed biological clock.
Ebisawa T. | 07/6/2013 |
| Reduced cry1 expression is associated with glioma. | Deregulated expression of cry1 and cry2 in human gliomas.
Luo Y, Wang F, Chen LA, Chen XW, Chen ZJ, Liu PF, li FF, Li CY, Liang W. | 07/6/2013 |
| Loss of Cry1 expression is associated with skin tumors. | Altered expression patterns of clock gene mRNAs and clock proteins in human skin tumors.
Lengyel Z, Lovig C, Kommedal S, Keszthelyi R, Szekeres G, Battyáni Z, Csernus V, Nagy AD. | 05/11/2013 |
| type II protein arginine methyltransferase 5 has a role in the regulation of Circadian Per1 and CRY1 genes | Role of type II protein arginine methyltransferase 5 in the regulation of Circadian Per1 gene.
Na J, Lee K, Kim HG, Shin JY, Na W, Jeong H, Lee JW, Cho S, Kim WS, Ju BG., Free PMC Article | 05/11/2013 |
| Genetic variants of CRY1 associate with depressive disorder. | Clock gene variants in mood and anxiety disorders.
Partonen T. | 03/9/2013 |
| USP2a potentially mediates circadian disruption by suppressing the CRY1 degradation during inflammation. | USP2a protein deubiquitinates and stabilizes the circadian protein CRY1 in response to inflammatory signals.
Tong X, Buelow K, Guha A, Rausch R, Yin L., Free PMC Article | 10/20/2012 |
| the CRY1-PHR domain(313-426), not the divergent C-terminal domain, is critical for clock function. | Identification of a novel cryptochrome differentiating domain required for feedback repression in circadian clock function.
Khan SK, Xu H, Ukai-Tadenuma M, Burton B, Wang Y, Ueda HR, Liu AC., Free PMC Article | 10/13/2012 |
| Human cryptochrome-1 confers light independent biological activity in transgenic Drosophila correlated with flavin radical stability. | Human cryptochrome-1 confers light independent biological activity in transgenic Drosophila correlated with flavin radical stability.
Vieira J, Jones AR, Danon A, Sakuma M, Hoang N, Robles D, Tait S, Heyes DJ, Picot M, Yoshii T, Helfrich-Förster C, Soubigou G, Coppee JY, Klarsfeld A, Rouyer F, Scrutton NS, Ahmad M., Free PMC Article | 08/25/2012 |
| The methylation pattern of the CRY1 promoter proved to have high prognostic impact in CLL where aberrant promoter methylation predicted a favourable outcome. | Epigenetic silencing of the circadian clock gene CRY1 is associated with an indolent clinical course in chronic lymphocytic leukemia.
Hanoun M, Eisele L, Suzuki M, Greally JM, Hüttmann A, Aydin S, Scholtysik R, Klein-Hitpass L, Dührsen U, Dürig J., Free PMC Article | 08/4/2012 |
| Clock genes expression is sex dependent in human adipose tissue from morbidly obese subjects and correlates to a decreased in metabolic syndrome-related traits. | Sexual dimorphism in clock genes expression in human adipose tissue.
Gómez-Abellán P, Madrid JA, Luján JA, Frutos MD, González R, Martínez-Augustín O, de Medina FS, Ordovás JM, Garaulet M., Free PMC Article | 04/28/2012 |
| Five SNPs were validated as being significantly associated with prostate cancer mortality, one each in the LEPR, CRY1, RNASEL, IL4, and ARVCF genes. | Genetic variants in the LEPR, CRY1, RNASEL, IL4, and ARVCF genes are prognostic markers of prostate cancer-specific mortality.
Lin DW, FitzGerald LM, Fu R, Kwon EM, Zheng SL, Kolb S, Wiklund F, Stattin P, Isaacs WB, Xu J, Ostrander EA, Feng Z, Grönberg H, Stanford JL., Free PMC Article | 03/24/2012 |
| There was no circadian rhythm of bmal1(brain and muscle ARNT-like 1) and cry1(cryptochrome 1) in PBMC of preterm neonates | The circadian rhythm of expression of Bmal1 and Cry1 in peripheral blood mononuclear cells of preterm neonates.
Chen A. | 01/8/2011 |
| Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) | The role of polymorphisms in circadian pathway genes in breast tumorigenesis.
Dai H, Zhang L, Cao M, Song F, Zheng H, Zhu X, Wei Q, Zhang W, Chen K. | 12/5/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Response to methadone maintenance treatment is associated with the MYOCD and GRM6 genes.
Fonseca F, Gratacòs M, Escaramís G, De Cid R, Martín-Santos R, Fernández-Espejo E, Estivill X, Torrens M. | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| differential expression and prognostic significance of the circadian genes CRY1 and PER2 in chronic lymphocytic leukemia | Combined PER2 and CRY1 expression predicts outcome in chronic lymphocytic leukemia.
Eisele L, Prinz R, Klein-Hitpass L, Nückel H, Lowinski K, Thomale J, Moeller LC, Dührsen U, Dürig J. | 01/21/2010 |
| Cryptochrome-1 was a valuable predictor of disease progression in early-stage chronic lymphocytic leukemia | Cryptochrome-1 expression: a new prognostic marker in B-cell chronic lymphocytic leukemia.
Lewintre EJ, Martín CR, Ballesteros CG, Montaner D, Rivera RF, Mayans JR, García-Conde J., Free PMC Article | 01/21/2010 |
| The regulators of clock-controlled transcription PER2, CRY1 and CRY2 differ in their capacity to interact with each single component of the BMAL1-CLOCK heterodimer and, in the case of BMAL1, also in their interaction sites. | Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK.
Langmesser S, Tallone T, Bordon A, Rusconi S, Albrecht U., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm.
Shi J, Wittke-Thompson JK, Badner JA, Hattori E, Potash JB, Willour VL, McMahon FJ, Gershon ES, Liu C., Free PMC Article | 04/3/2008 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (6) articlesGenetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ. Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance.
Utge SJ, Soronen P, Loukola A, Kronholm E, Ollila HM, Pirkola S, Porkka-Heiskanen T, Partonen T, Paunio T. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder.
Soria V, Martínez-Amorós E, Escaramís G, Valero J, Pérez-Egea R, García C, Gutiérrez-Zotes A, Puigdemont D, Bayés M, Crespo JM, Martorell L, Vilella E, Labad A, Vallejo J, Pérez V, Menchón JM, Estivill X, Gratacòs M, Urretavizcaya M. Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study.
Zhu Y, Stevens RG, Hoffman AE, Fitzgerald LM, Kwon EM, Ostrander EA, Davis S, Zheng T, Stanford JL. PER2 variantion is associated with depression vulnerability.
Lavebratt C, Sjöholm LK, Partonen T, Schalling M, Forsell Y. Genotype patterns that contribute to increased risk for or protection from developing heroin addiction.
Nielsen DA, Ji F, Yuferov V, Ho A, Chen A, Levran O, Ott J, Kreek MJ. | 03/13/2008 |
| Cry1 may be a candidate gene of schizophrenia. The proposition may have new clues on the development of genetic study on complex diseases | Cryptochrome1 maybe a candidate gene of schizophrenia.
Peng ZW, Chen XG, Wei Z. | 01/21/2010 |
| Linkage disequilibrium analyses using single SNPs and haplotypes showed no association to bipolar disease. | Examination of the clock gene Cryptochrome 1 in bipolar disorder: mutational analysis and absence of evidence for linkage or association.
Nievergelt CM, Kripke DF, Remick RA, Sadovnick AD, McElroy SL, Keck PE Jr, Kelsoe JR. | 01/21/2010 |
| the CLOCK(NPAS2)/BMAL1 complex is post-translationally regulated by cry1 and cry2 | Post-translational regulation of circadian transcriptional CLOCK(NPAS2)/BMAL1 complex by CRYPTOCHROMES.
Kondratov RV, Kondratova AA, Lee C, Gorbacheva VY, Chernov MV, Antoch MP. | 01/21/2010 |