| results demonstrate a role for Slc11a1 (Nramp1) in modifying susceptibility to type 1 diabetes and illustrate that RNAi can be used to study causal genes in a mammalian model organism | In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes.
Kissler S, Stern P, Takahashi K, Hunter K, Peterson LB, Wicker LS. | 01/21/2010 |
| These results indicate that Slc11a1 is a strong candidate for the QTL modulating acute inflammation and for pristane-induced arthritis. | Slc11a1 (formerly NRAMP1) gene modulates both acute inflammatory reactions and pristane-induced arthritis in mice.
Peters LC, Jensen JR, Borrego A, Cabrera WH, Baker N, Starobinas N, Ribeiro OG, Ibañez OM, De Franco M. | 01/21/2010 |
| Nramp1 promoter is transactivated by Miz-1 | Characterization of the murine Nramp1 promoter: requirements for transactivation by Miz-1.
Bowen H, Lapham A, Phillips E, Yeung I, Alter-Koltunoff M, Levi BZ, Perry VH, Mann DA, Barton CH. | 01/21/2010 |
| Nramp1 controls macrophage secretory leukocyte protease inhibitor mRNA and protein expression, and can also have an important effect on the kinetics of wound healing. | Delayed cutaneous wound healing in mice lacking solute carrier 11a1 (formerly Nramp1): correlation with decreased expression of secretory leukocyte protease inhibitor.
Thuraisingam T, Sam H, Moisan J, Zhang Y, Ding A, Radzioch D. | 01/21/2010 |
| repression of promoter by c-Myc and activation by Miz-1 | c-Myc represses and Miz-1 activates the murine natural resistance-associated protein 1 promoter.
Bowen H, Biggs TE, Phillips E, Baker ST, Perry VH, Mann DA, Barton CH. | 01/21/2010 |
| Host resistance factor Nramp1 up-regulates the expression of Salmonella pathogenicity island-2 virulence genes. | Host-pathogen interactions: Host resistance factor Nramp1 up-regulates the expression of Salmonella pathogenicity island-2 virulence genes.
Zaharik ML, Vallance BA, Puente JL, Gros P, Finlay BB., Free PMC Article | 01/21/2010 |
| The epigenetic regulator, Lsh, is directly involved in the control of de novo methylation of DNA. | Lsh is involved in de novo methylation of DNA.
Zhu H, Geiman TM, Xi S, Jiang Q, Schmidtmann A, Chen T, Li E, Muegge K., Free PMC Article | 01/21/2010 |
| Data demonstrate a role for NRAMP1 in modulating p38 MAPK and PKCzeta activity, which leads to reduced cytokine induction by TLR7 ligands. | Role of SLC11A1 (formerly NRAMP1) in regulation of signal transduction induced by Toll-like receptor 7 ligands.
Moisan J, Thuraisingam T, Henault J, De Sanctis J, Radzioch D. | 01/21/2010 |
| The pattern of susceptibility of congenic mouse strains infected with Paracoccidioides brasiliensis resembles the pattern of the Nramp1 gene. | Importance of complement 3 and mannose receptors in phagocytosis of Paracoccidioides brasiliensis conidia by Nramp1 congenic macrophages lines.
Jiménez Mdel P, Restrepo A, Radzioch D, Cano LE, García LF. | 01/21/2010 |
| Nramp1-expressing RAW264.7 macrophages present with increased nitric oxide formation and inducible nitric oxide synthase (iNOS) activity following cytokine stimulation, which can be related to enhanced and prolonged iNOS mRNA expression. | Nramp1 functionality increases inducible nitric oxide synthase transcription via stimulation of IFN regulatory factor 1 expression.
Fritsche G, Dlaska M, Barton H, Theurl I, Garimorth K, Weiss G. | 01/21/2010 |
| Salmonella typhimurium can persist for as long as 1 yr in the mesenteric lymph nodes (MLNs) of 129sv Nramp1(+)(/)(+) (Slc11a1(+)(/)(+)) mice despite the presence of high levels of anti-S. typhimurium antibody. | Salmonella typhimurium persists within macrophages in the mesenteric lymph nodes of chronically infected Nramp1+/+ mice and can be reactivated by IFNgamma neutralization.
Monack DM, Bouley DM, Falkow S., Free PMC Article | 01/21/2010 |
| To investigate the molecular pathogenesis of infectious disease susceptibility, we compared the behaviour of heterologously and endogenously expressed wild-type and mutant Slc11a1. | Incomplete glycosylation and defective intracellular targeting of mutant solute carrier family 11 member 1 (Slc11a1).
White JK, Stewart A, Popoff JF, Wilson S, Blackwell JM., Free PMC Article | 01/21/2010 |
| Nramp1 alleles clearly affect the efficacy of heat-killed Mycobacterium vaccae in diminishing the allergic and asthmatic response in a mouse model. | The Slc11a1 (Nramp1) gene controls efficacy of mycobacterial treatment of allergic asthma.
Smit JJ, Van Loveren H, Hoekstra MO, Karimi K, Folkerts G, Nijkamp FP. | 01/21/2010 |
| Disruption of the Slc11a1 gene in Kupffer cells attenuates early-phase, warm ischemia-reperfusion injury in the mouse liver. | Disruption of the Nramp1 (also known as Slc11a1) gene in Kupffer cells attenuates early-phase, warm ischemia-reperfusion injury in the mouse liver.
Wyllie S, Seu P, Gao FQ, Gros P, Goss JA. | 01/21/2010 |
| Affects macrophage-mediated anti-cryptococcal defense | Nramp1 gene affects selective early steps in macrophage-mediated anti-cryptococcal defense.
Blasi E, Colombari B, Mucci A, Cossarizza A, Radzioch D, Boelaert JR, Neglia R. | 01/21/2010 |
| findings demonstrate that acute inflammatory reactions quantitative trait loci (AIR QTL) can act as modifiers of the Slc11a1(SS) susceptibility gene for Salmonella typhimurium infections | Genetic determinants of acute inflammation regulate Salmonella infection and modulate Slc11a1 gene (formerly Nramp1) effects in selected mouse lines.
Borrego A, Peters LC, Jensen JR, Ribeiro OG, Koury Cabrera WH, Starobinas N, Seman M, Ibañez OM, De Franco M. | 01/21/2010 |
| Data show that M. avium was unable to prevent phagosome maturation and fusion with lysosomes but that in Nramp1-negative macrophages this capacity was restored. | Effect of Nramp1 on bacterial replication and on maturation of Mycobacterium avium-containing phagosomes in bone marrow-derived mouse macrophages.
Frehel C, Canonne-Hergaux F, Gros P, De Chastellier C. | 01/21/2010 |