| Melanoma cell lines, including those with ETV1 amplification, exhibited dependency on ETV1 expression for proliferation and anchorage-independent growth. | An oncogenic role for ETV1 in melanoma.
Jané-Valbuena J, Widlund HR, Perner S, Johnson LA, Dibner AC, Lin WM, Baker AC, Nazarian RM, Vijayendran KG, Sellers WR, Hahn WC, Duncan LM, Rubin MA, Fisher DE, Garraway LA., Free PMC Article | 04/12/2010 |
| ERG/ETV1 gene rearrangements and PTEN gene loss status should now prospectively be incorporated into a predictive model to establish whether predictive performance is improved. | Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer.
Reid AH, Attard G, Ambroisine L, Fisher G, Kovacs G, Brewer D, Clark J, Flohr P, Edwards S, Berney DM, Foster CS, Fletcher A, Gerald WL, Møller H, Reuter VE, Scardino PT, Cuzick J, de Bono JS, Cooper CS, Transatlantic Prostate Group., Free PMC Article | 03/29/2010 |
| Overexpression of ETV1 is associated with tha induction of prostatic intraepithelial neoplasia. | Induction of prostatic intraepithelial neoplasia and modulation of androgen receptor by ETS variant 1/ETS-related protein 81.
Shin S, Kim TD, Jin F, van Deursen JM, Dehm SM, Tindall DJ, Grande JP, Munz JM, Vasmatzis G, Janknecht R., Free PMC Article | 01/21/2010 |
| 1% histologic variant of prostate carcinoma or variation morphologies demonstrated ETV! aberrations | Characterization of ETS gene aberrations in select histologic variants of prostate carcinoma.
Han B, Mehra R, Suleman K, Tomlins SA, Wang L, Singhal N, Linetzky KA, Palanisamy N, Zhou M, Chinnaiyan AM, Shah RB., Free PMC Article | 01/21/2010 |
| Transcriptional activation of hTERT in breast carcinomas by the Her2-ER81-related pathway. | Transcriptional activation of hTERT in breast carcinomas by the Her2-ER81-related pathway.
Vageli D, Ioannou MG, Koukoulis GK. | 01/21/2010 |
| Observational study of gene-disease association, gene-gene interaction, and genetic testing. (HuGE Navigator) | Utility of incorporating genetic variants for the early detection of prostate cancer.
Nam RK, Zhang WW, Trachtenberg J, Seth A, Klotz LH, Stanimirovic A, Punnen S, Venkateswaran V, Toi A, Loblaw DA, Sugar L, Siminovitch KA, Narod SA. | 03/25/2009 |
| ETV1 and HER2/Neu synergized to upregulate the endogenous Rcl gene. ETV1 also bound to the Rcl promoter. | Rcl is a novel ETV1/ER81 target gene upregulated in breast tumors.
Shin S, Bosc DG, Ingle JN, Spelsberg TC, Janknecht R. | 01/21/2010 |
| Sox-9, ER81 and VE-cadherin have roles in retinoic acid-mediated trans-differentiation of breast cancer cells | Role of Sox-9, ER81 and VE-cadherin in retinoic acid-mediated trans-differentiation of breast cancer cells.
Endo Y, Deonauth K, Prahalad P, Hoxter B, Zhu Y, Byers SW., Free PMC Article | 01/21/2010 |
| Studies report a novel fusion partner for ETV1 and highlight the considerable heterogeneity of ETV1 gene rearrangements in human prostate cancer. | Heterogeneity and clinical significance of ETV1 translocations in human prostate cancer.
Attard G, Clark J, Ambroisine L, Mills IG, Fisher G, Flohr P, Reid A, Edwards S, Kovacs G, Berney D, Foster C, Massie CE, Fletcher A, De Bono JS, Scardino P, Cuzick J, Cooper CS, Transatlantic Prostate Group., Free PMC Article | 01/21/2010 |
| Detection of ETS fusion gene by RT-PCR is feasible on formalin-fixed and paraffin-embedded samples. | Detection of the TMPRSS2-ETS fusion gene in prostate carcinomas: retrospective analysis of 55 formalin-fixed and paraffin-embedded samples with clinical data.
Rouzier C, Haudebourg J, Carpentier X, Valério L, Amiel J, Michiels JF, Pedeutour F. | 01/21/2010 |
| findings show that the TMPRSS2-ERG fusion is common in prostate cancer and that the related TMPRSS2-ETV1 fusion is very rare | Molecular genetic analyses of the TMPRSS2-ERG and TMPRSS2-ETV1 gene fusions in 50 cases of prostate cancer.
Winnes M, Lissbrant E, Damber JE, Stenman G. | 01/21/2010 |
| TMPRSS2-ERV1 fusion protein was found in 1/82 prostate neoplasms. | Gene fusions between TMPRSS2 and ETS family genes in prostate cancer: frequency and transcript variant analysis by RT-PCR and FISH on paraffin-embedded tissues.
Tu JJ, Rohan S, Kao J, Kitabayashi N, Mathew S, Chen YT. | 01/21/2010 |
| Expression transitions from androgen-induced to androgen-independent as prostate cancer cells switch from hormone-dependent to hormone-refractory. | ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion.
Cai C, Hsieh CL, Omwancha J, Zheng Z, Chen SY, Baert JL, Shemshedini L. | 01/21/2010 |
| These results imply that c-Jun plays a pivotal role in the pathway that connects ligand-activated AR to elevated ETV1 expression, leading to enhanced expression of matrix metalloproteinases and prostate cancer cell invasion. | c-Jun has multiple enhancing activities in the novel cross talk between the androgen receptor and Ets variant gene 1 in prostate cancer.
Cai C, Hsieh CL, Shemshedini L. | 01/21/2010 |
| transcription factor ER81 is regulated by oncogenic HER2/Neu and ACTR in mammary tumorigenesis | Concerted activation of ETS protein ER81 by p160 coactivators, the acetyltransferase p300 and the receptor tyrosine kinase HER2/Neu.
Goel A, Janknecht R. | 01/21/2010 |
| attenuation of transforming growth factor-beta signaling by activating Smad7 transcription may proceed not only through TGF-beta receptor-regulated Smad proteins but also an independent pathway involving transcription factor ER81 and TAK1 protein kinase | HER2/Neu- and TAK1-mediated up-regulation of the transforming growth factor beta inhibitor Smad7 via the ETS protein ER81.
Dowdy SC, Mariani A, Janknecht R. | 01/21/2010 |
| ER81 is acetylated by two coactivators/acetyltransferases, p300 and p300- and CBP-associated factor (P/CAF) . Whereas p300 acetylates two lysine residues (K33 and K116) within the ER81 N-terminal transactivation domain, P/CAF targets only K116. | Acetylation-mediated transcriptional activation of the ETS protein ER81 by p300, P/CAF, and HER2/Neu.
Goel A, Janknecht R., Free PMC Article | 01/21/2010 |
| demonstrate for the first time that the TMPRSS2-ERG fusion gene can be detected in a proportion of HGPIN lesions and that this molecular rearrangement is an early event that may precede chromosome-level alterations in prostate carcinogenesis | TMPRSS2-ERG gene fusion causing ERG overexpression precedes chromosome copy number changes in prostate carcinomas and paired HGPIN lesions.
Cerveira N, Ribeiro FR, Peixoto A, Costa V, Henrique R, Jerónimo C, Teixeira MR., Free PMC Article | 01/21/2010 |