| MED1 and GATA-6 are key regulators of SULT2A1 expression, and they play important roles in adrenal androgen production. | The mediator complex subunit 1 enhances transcription of genes needed for adrenal androgen production.
Nakamura Y, Xing Y, Sasano H, Rainey WE., Free PMC Article | 01/21/2010 |
| Loss of Med1 expression directly correlates with a loss of dapk1 expression in a number of human lung cancers and cancer cell lines. | Down-regulation of the transcriptional mediator subunit Med1 contributes to the loss of expression of metastasis-associated dapk1 in human cancers and cancer cells.
Gade P, Singh AK, Roy SK, Reddy SP, Kalvakolanu DV., Free PMC Article | 01/21/2010 |
| a decrease of RB18A/MED1 expression in human melanoma cells increases their tumorigenic phenotype. | Down-regulation of the expression of RB18A/MED1, a cofactor of transcription, triggers strong tumorigenic phenotype of human melanoma cells.
Ndong Jde L, Jean D, Rousselet N, Frade R. | 01/21/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | See all PubMed (2) articlesVitamin D-related genes, serum vitamin D concentrations and prostate cancer risk.
Ahn J, Albanes D, Berndt SI, Peters U, Chatterjee N, Freedman ND, Abnet CC, Huang WY, Kibel AS, Crawford ED, Weinstein SJ, Chanock SJ, Schatzkin A, Hayes RB, Prostate, Lung, Colorectal and Ovarian Trial Project Team. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort.
Haiman CA, Garcia RR, Hsu C, Xia L, Ha H, Sheng X, Le Marchand L, Kolonel LN, Henderson BE, Stallcup MR, Greene GL, Press MF. | 02/11/2009 |
| ERK phosphorylation of MED1 is a regulatory mechanism that promotes MED1 association with Mediator and, as such, may facilitate a novel feed-forward action of nuclear hormones | MED1 phosphorylation promotes its association with mediator: implications for nuclear receptor signaling.
Belakavadi M, Pandey PK, Vijayvargia R, Fondell JD., Free PMC Article | 01/21/2010 |
| ERK-regulated site in Med1 protein is also essential for up-regulating interferon-induced transcription although not critical for binding to C/EBP-beta | The Med1 subunit of transcriptional mediator plays a central role in regulating CCAAT/enhancer-binding protein-beta-driven transcription in response to interferon-gamma.
Li H, Gade P, Nallar SC, Raha A, Roy SK, Karra S, Reddy JK, Reddy SP, Kalvakolanu DV., Free PMC Article | 01/21/2010 |
| phosphorylation of RXRalpha at serine 260 impaired the recruitment of DRIP205 and other coactivators to the VDR.RXRalpha complex | Phosphorylation of the human retinoid X receptor alpha at serine 260 impairs coactivator(s) recruitment and induces hormone resistance to multiple ligands.
Macoritto M, Nguyen-Yamamoto L, Huang DC, Samuel S, Yang XF, Wang TT, White JH, Kremer R. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (5) articlesGene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study.
Vega A, Salas A, Milne RL, Carracedo B, Ribas G, Ruibal A, de León AC, González-Hernández A, Benítez J, Carracedo A. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, van 't Slot R, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM. HapMap-based study of the 17q21 ERBB2 amplicon in susceptibility to breast cancer.
Benusiglio PR, Pharoah PD, Smith PL, Lesueur F, Conroy D, Luben RN, Dew G, Jordan C, Dunning A, Easton DF, Ponder BA. Genotypic and phenotypic differences between Arabian and Scandinavian women with gestational diabetes mellitus.
Shaat N, Ekelund M, Lernmark A, Ivarsson S, Nilsson A, Perfekt R, Berntorp K, Groop L. | 03/13/2008 |
| MED1/TRAP220 is the nuclear receptor-interacting subunit of the Mediator complex and is required for PPARgamma-stimulated adipogenesis. | Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis.
Ge K, Guermah M, Yuan CX, Ito M, Wallberg AE, Spiegelman BM, Roeder RG. | 12/4/2007 |
| Recruitment of CBP and TRAP220 was diminished by the overexpression of a MED25 NR box deletion mutant, and by treatment with MED25 siRNA | MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation.
Lee HK, Park UH, Kim EJ, Um SJ., Free PMC Article | 01/21/2010 |
| RB18A plays a central role to control p53wt and p53mut protein content and functions in cells through a loop of regulation, which involves MDM2 | RB18A enhances expression of mutant p53 protein in human cells.
Lottin-Divoux S, Barel M, Frade R. | 01/21/2010 |
| DRIP205 has a role as a coactivator of FXR | Identification of DRIP205 as a coactivator for the Farnesoid X receptor.
Pineda Torra I, Freedman LP, Garabedian MJ. | 01/21/2010 |
| MED14 and MED1 are used by glucocorticoid receptor in a gene-specific manner, providing a mechanism for promoter selectivity by glucocorticoid receptor | MED14 and MED1 differentially regulate target-specific gene activation by the glucocorticoid receptor.
Chen W, Rogatsky I, Garabedian MJ. | 01/21/2010 |
| TFIID and human mediator coactivator (TRAP220) complexes assemble cooperatively on promoter DNA | TFIID and human mediator coactivator complexes assemble cooperatively on promoter DNA.
Johnson KM, Wang J, Smallwood A, Arayata C, Carey M., Free PMC Article | 01/21/2010 |
| regulates p53-dependent apoptosis | RB18A regulates p53-dependent apoptosis.
Frade R, Balbo M, Barel M. | 01/21/2010 |
| ERK-mediated phosphorylation is a regulatory mechanism that controls TRAP220/Med1 expression levels and modulates its functional activity. | Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation.
Pandey PK, Udayakumar TS, Lin X, Sharma D, Shapiro PS, Fondell JD., Free PMC Article | 01/21/2010 |
| Both DRIP205 and SRC-3 are required for the keratinocyte differentiation | Differential role of two VDR coactivators, DRIP205 and SRC-3, in keratinocyte proliferation and differentiation.
Oda Y, Ishikawa MH, Hawker NP, Yun QC, Bikle DD. | 01/21/2010 |
| there is a coregulatory role for subunits of this protein in androgen receptor-mediated gene expression | A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression.
Wang Q, Sharma D, Ren Y, Fondell JD. | 01/21/2010 |
| Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation | Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation.
Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS, Thimmapaya B, Zhu Y, Reddy JK. | 01/21/2010 |
| DRIP205 coactivation of estrogen receptor alpha (ERalpha) involves multiple domains of both proteins | Vitamin D-interacting protein 205 (DRIP205) coactivation of estrogen receptor alpha (ERalpha) involves multiple domains of both proteins.
Wu Q, Burghardt R, Safe S. | 01/21/2010 |
| TRAP220/MED1 plays a novel coregulatory role in facilitating the recruitment of TRAP/Mediator to specific target genes involved in growth and cell cycle progression via GABP | Regulation of Aurora-A kinase gene expression via GABP recruitment of TRAP220/MED1.
Udayakumar TS, Belakavadi M, Choi KH, Pandey PK, Fondell JD. | 01/21/2010 |
| Expression of TRAP220 mRNA and protein was shown to be decreased significantly in the temporal cortex of patients with epilepsy. | Decreased expression of thyroid receptor-associated protein 220 in temporal lobe tissue of patients with refractory epilepsy.
Li JM, Wang XF, Xi ZQ, Gong Y, Liu FY, Sun JJ, Wu Y, Luan GM, Wang YP, Li YL, Zhang JG, Lu Y, Li HW. | 01/21/2010 |
| extended LXXLL motif sequence determines the nuclear receptor binding specificity | An extended LXXLL motif sequence determines the nuclear receptor binding specificity of TRAP220.
Coulthard VH, Matsuda S, Heery DM. | 01/21/2010 |
| examination of regulation by cellular signaling pathways | Phosphorylation of transcriptional coactivator peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP). Stimulation of transcriptional regulation by mitogen-activated protein kinase.
Misra P, Owuor ED, Li W, Yu S, Qi C, Meyer K, Zhu YJ, Rao MS, Kong AN, Reddy JK. | 01/21/2010 |
| Med1 depleted cells exhibited an exacerbated response to retinoids, both in terms transcriptional responses and of cellular differentiation. | Distinct roles of the steroid receptor coactivator 1 and of MED1 in retinoid-induced transcription and cellular differentiation.
Flajollet S, Lefebvre B, Rachez C, Lefebvre P. | 01/21/2010 |