| an unglycosylated Sap-B variant, Asn215His, which causes a fatal sphingolipid storage disease, lost the ability to extract membrane lipids at acidic pH in the presence of BMP | Saposin B mobilizes lipids from cholesterol-poor and bis(monoacylglycero)phosphate-rich membranes at acidic pH. Unglycosylated patient variant saposin B lacks lipid-extraction capacity.
Remmel N, Locatelli-Hoops S, Breiden B, Schwarzmann G, Sandhoff K. | 01/21/2010 |
| FSAP (Factor VII-activating protease) can cleave and inactivate PDGF-BB (platelet-derived growth factor-BB) and thereby inhibits VSMC (vascular smooth-muscle cell) proliferation. | Nucleic acids potentiate Factor VII-activating protease (FSAP)-mediated cleavage of platelet-derived growth factor-BB and inhibition of vascular smooth muscle cell proliferation.
Shibamiya A, Muhl L, Tannert-Otto S, Preissner KT, Kanse SM., Free PMC Article | 01/21/2010 |
| saposin B may facilitate lipid binding to CD1d molecules throughout the endocytic pathway | Saposin B is the dominant saposin that facilitates lipid binding to human CD1d molecules.
Yuan W, Qi X, Tsang P, Kang SJ, Illarionov PA, Besra GS, Gumperz J, Cresswell P., Free PMC Article | 01/21/2010 |
| The structure of saposin C compared to other saposin-fold family members provides an explanation for function variability of this protein family. | Solution structure of human saposin C: pH-dependent interaction with phospholipid vesicles.
de Alba E, Weiler S, Tjandra N. | 01/21/2010 |
| There might be a potential pleuripotent regulatory function for prosaposin in prostate cancer. | Prosaptide TX14A stimulates growth, migration, and invasion and activates the Raf-MEK-ERK-RSK-Elk-1 signaling pathway in prostate cancer cells.
Koochekpour S, Sartor O, Lee TJ, Zieske A, Patten DY, Hiraiwa M, Sandhoff K, Remmel N, Minokadeh A. | 01/21/2010 |
| crystal structure reveals a dimeric shell for lipid binding | Crystal structure of saposin B reveals a dimeric shell for lipid binding.
Ahn VE, Faull KF, Whitelegge JP, Fluharty AL, Privé GG., Free PMC Article | 01/21/2010 |
| model proposed in which saposin C exposes lipid antigens from intralysosomal membranes for loading onto CD1b | Saposin C is required for lipid presentation by human CD1b.
Winau F, Schwierzeck V, Hurwitz R, Remmel N, Sieling PA, Modlin RL, Porcelli SA, Brinkmann V, Sugita M, Sandhoff K, Kaufmann SH, Schaible UE. | 01/21/2010 |
| reconstruction of the order of internal duplications that gave rise to the four saposins by using phylogenetic tools | The evolutionary history of prosaposin: two successive tandem-duplication events gave rise to the four saposin domains in vertebrates.
Hazkani-Covo E, Altman N, Horowitz M, Graur D. | 01/21/2010 |
| data indicate that saposin C is required for acid beta-glucosidase resistance to proteolytic degradation in the cell | Saposin C is required for normal resistance of acid beta-glucosidase to proteolytic degradation.
Sun Y, Qi X, Grabowski GA. | 01/21/2010 |
| Prosaposin is an androgen-target gene and its expression in androgen-responsive prostate cancer cells can be upregulated by male hormones. | Prosaposin is a novel androgen-regulated gene in prostate cancer cell line LNCaP.
Koochekpour S, Lee TJ, Wang R, Sun Y, Delorme N, Hiraiwa M, Grabowski GA, Culig Z, Minokadeh A. | 05/31/2019 |
| Saposin C stimulates prostate cancer and stromal cells growth and invasion and uPA/uPAR expression, and activates p42/44 and SAPK/JNK signaling pathways of MAPK. | Saposin C stimulates growth and invasion, activates p42/44 and SAPK/JNK signaling pathways of MAPK and upregulates uPA/uPAR expression in prostate cancer and stromal cells.
Koochekpour S, Sartor O, Hiraiwa M, Lee TJ, Rayford W, Remmel N, Sandhoff K, Minokadeh A, Patten DY. | 05/19/2005 |
| Prosaposin and/or saposin C via modulation of caspases expression/activity and/or PI3K/Akt signaling pathway act as a survival and anti-apoptotic factor for prostate cancer cells. | Saposin C promotes survival and prevents apoptosis via PI3K/Akt-dependent pathway in prostate cancer cells.
Lee TJ, Sartor O, Luftig RB, Koochekpour S., Free PMC Article | 04/25/2005 |
| procathepsin D interacts with prosaposin in human breast and ovarian cancer cells. | Procathepsin D interacts with prosaposin in cancer cells but its internalization is not mediated by LDL receptor-related protein.
Laurent-Matha V, Lucas A, Huttler S, Sandhoff K, Garcia M, Rochefort H. | 01/21/2010 |