| results demonstrate for the first time that prostacyclin receptor activation by cicaprost can lead to STAT1 and STAT3 phosphorylations via signaling pathways involving pertussis toxin-insensitive G proteins, ERK and JNK | Prostacyclin receptor induces STAT1 and STAT3 phosphorylations in human erythroleukemia cells: a mechanism requiring PTX-insensitive G proteins, ERK and JNK.
Lo RK, Wise H, Wong YH. | 01/21/2010 |
| Three Arg-targeted changes at the same 212 position within the third cytoplasmic loop of the human prostacyclin (hIP) receptor were detected. | Arginine (CGC) codon targeting in the human prostacyclin receptor gene (PTGIR) and G-protein coupled receptors (GPCR).
Stitham J, Arehart EJ, Gleim S, Douville K, MacKenzie T, Hwa J., Free PMC Article | 01/21/2010 |
| elucidated the molecular requirements for receptor activation within the region of the ligand-binding pocket, identifying transmembrane residues affecting potency | Clusters of transmembrane residues are critical for human prostacyclin receptor activation.
Stitham J, Stojanovic A, Ross LA, Blount AC Jr, Hwa J. | 01/21/2010 |
| The first intracellular loop of human prostacyclin receptor (IP) was proposed to be involved in signaling via its interaction with the Galphas protein. | A profile of the residues in the first intracellular loop critical for Gs-mediated signaling of human prostacyclin receptor characterized by an integrative approach of NMR-experiment and mutagenesis.
Zhang L, Huang G, Wu J, Ruan KH. | 01/21/2010 |
| results indicate that the three residues (E392-L394) of the Galphas protein predicted from NMR peptide studies, and the IP iLP1 and iLP3 play important roles in the Galphas-mediated IP receptor signaling in the cells. | Characterization of the molecular mechanisms of the coupling between intracellular loops of prostacyclin receptor with the C-terminal domain of the Galphas protein in human coronary artery smooth muscle cells.
Zhang L, Bastepe M, Jüppner H, Ruan KH. | 01/21/2010 |