| Advances in understanding the function of alpha-synuclein: implications for Parkinson's disease. | Advances in understanding the function of alpha-synuclein: implications for Parkinson's disease.
Calabresi P, Di Lazzaro G, Marino G, Campanelli F, Ghiglieri V., Free PMC Article | 09/7/2023 |
| Alpha-synuclein-associated changes in PINK1-PRKN-mediated mitophagy are disease context dependent. | Alpha-synuclein-associated changes in PINK1-PRKN-mediated mitophagy are disease context dependent.
Hou X, Chen TH, Koga S, Bredenberg JM, Faroqi AH, Delenclos M, Bu G, Wszolek ZK, Carr JA, Ross OA, McLean PJ, Murray ME, Dickson DW, Fiesel FC, Springer W., Free PMC Article | 08/31/2023 |
| Meta-analysis to Implement Alpha-Synuclein in Extracellular Vesicles as a Potential Biomarker for Parkinsons Disease. | Meta-analysis to Implement Alpha-Synuclein in Extracellular Vesicles as a Potential Biomarker for Parkinsons Disease.
Juárez-Vaquera VH, Rosetti-Sciutto MF, Morales-Ruiz V, Adalid-Peralta LV. | 08/30/2023 |
| Amyloids of alpha-Synuclein Promote Chemical Transformations of Neuronal Cell Metabolites. | Amyloids of α-Synuclein Promote Chemical Transformations of Neuronal Cell Metabolites.
Horvath I, Mohamed KA, Kumar R, Wittung-Stafshede P., Free PMC Article | 08/30/2023 |
| The alpha-synuclein oligomers activate nuclear factor of activated T-cell (NFAT) modulating synaptic homeostasis and apoptosis. | The alpha-synuclein oligomers activate nuclear factor of activated T-cell (NFAT) modulating synaptic homeostasis and apoptosis.
Sant'Anna R, Robbs BK, de Freitas JA, Dos Santos PP, König A, Outeiro TF, Foguel D., Free PMC Article | 08/25/2023 |
| alpha-Synuclein Strains and Their Relevance to Parkinson's Disease, Multiple System Atrophy, and Dementia with Lewy Bodies. | α-Synuclein Strains and Their Relevance to Parkinson's Disease, Multiple System Atrophy, and Dementia with Lewy Bodies.
Graves NJ, Gambin Y, Sierecki E., Free PMC Article | 08/19/2023 |
| E46K Mutation of alpha-Synuclein Preorganizes the Intramolecular Interactions Crucial for Aggregation. | E46K Mutation of α-Synuclein Preorganizes the Intramolecular Interactions Crucial for Aggregation.
Huang D, Guo C. | 08/19/2023 |
| Acetylated alpha-Tubulin and alpha-Synuclein: Physiological Interplay and Contribution to alpha-Synuclein Oligomerization. | Acetylated α-Tubulin and α-Synuclein: Physiological Interplay and Contribution to α-Synuclein Oligomerization.
Calogero AM, Basellini MJ, Isilgan HB, Longhena F, Bellucci A, Mazzetti S, Rolando C, Pezzoli G, Cappelletti G., Free PMC Article | 08/14/2023 |
| Upregulation of Parkinson's disease-associated protein alpha-synuclein suppresses tumorigenesis via interaction with mGluR5 and gamma-synuclein in liver cancer. | Upregulation of Parkinson's disease-associated protein alpha-synuclein suppresses tumorigenesis via interaction with mGluR5 and gamma-synuclein in liver cancer.
Yang HM, Cheng YZ, Hou TZ, Fan JK, Gu L, Zhang JN, Zhang H. | 08/9/2023 |
| Cellular processing of alpha-synuclein fibrils results in distinct physiological C-terminal truncations with a major cleavage site at residue Glu 114. | Cellular processing of α-synuclein fibrils results in distinct physiological C-terminal truncations with a major cleavage site at residue Glu 114.
Quintin S, Lloyd GM, Paterno G, Xia Y, Sorrentino Z, Bell BM, Gorion KM, Lee EB, Prokop S, Giasson BI., Free PMC Article | 08/4/2023 |
| RAGE Against the Glycation Machine in Synucleinopathies: Time to Explore New Questions. | RAGE Against the Glycation Machine in Synucleinopathies: Time to Explore New Questions.
Gelain DP, Bittencourt RR, Bastos Mendes LF, Moreira JCF, Outeiro TF., Free PMC Article | 08/2/2023 |
| Parkinson's disease-linked V15A mutation facilitates alpha-synuclein aggregation by reducing membrane affinity. | Parkinson's disease-linked V15A mutation facilitates α-synuclein aggregation by reducing membrane affinity.
Buratti FA, Fernández CO, Zweckstetter M., Free PMC Article | 08/1/2023 |
| Carboxyl truncation of alpha-synuclein occurs early and is influenced by human APOE genotype in transgenic mouse models of alpha-synuclein pathogenesis. | Carboxyl truncation of α-synuclein occurs early and is influenced by human APOE genotype in transgenic mouse models of α-synuclein pathogenesis.
Lloyd GM, Long B, Quintin S, Sorrentino ZA, Gorion KM, Bell BM, Carrillo D, Sullivan P, Borchelt D, Giasson BI., Free PMC Article | 07/27/2023 |
| METTL14 is decreased and regulates m[6] A modification of alpha-synuclein in Parkinson's disease. | METTL14 is decreased and regulates m(6) A modification of α-synuclein in Parkinson's disease.
He H, Zhang Q, Liao J, Lei J, Luo M, Huang J, Chen M, Shen Y, Wang J, Xu P, Xiao Y. | 07/26/2023 |
| Advanced human iPSC-based preclinical model for Parkinson's disease with optogenetic alpha-synuclein aggregation. | Advanced human iPSC-based preclinical model for Parkinson's disease with optogenetic alpha-synuclein aggregation.
Kim MS, Ra EA, Kweon SH, Seo BA, Ko HS, Oh Y, Lee G., Free PMC Article | 07/12/2023 |
| Intramolecular interaction kinetically regulates fibril formation by human and mouse alpha-synuclein. | Intramolecular interaction kinetically regulates fibril formation by human and mouse α-synuclein.
Ohgita T, Kono H, Morita I, Oyama H, Shimanouchi T, Kobayashi N, Saito H., Free PMC Article | 07/10/2023 |
| Disease-Specific alpha-Synuclein Seeding in Lewy Body Disease and Multiple System Atrophy Are Preserved in Formaldehyde-Fixed Paraffin-Embedded Human Brain. | Disease-Specific α-Synuclein Seeding in Lewy Body Disease and Multiple System Atrophy Are Preserved in Formaldehyde-Fixed Paraffin-Embedded Human Brain.
Kim A, Martinez-Valbuena I, Li J, Lang AE, Kovacs GG., Free PMC Article | 07/5/2023 |
| Kinetic control in amyloid polymorphism: Different agitation and solution conditions promote distinct amyloid polymorphs of alpha-synuclein. | Kinetic control in amyloid polymorphism: Different agitation and solution conditions promote distinct amyloid polymorphs of alpha-synuclein.
Devi S, Garg DK, Bhat R. | 06/23/2023 |
| Knocking out alpha-synuclein in melanoma cells downregulates L1CAM and decreases motility. | Knocking out alpha-synuclein in melanoma cells downregulates L1CAM and decreases motility.
Gajendran N, Rajasekaran S, Witt SN., Free PMC Article | 06/15/2023 |
| Multifaceted interactions mediated by intrinsically disordered regions play key roles in alpha synuclein aggregation. | Multifaceted interactions mediated by intrinsically disordered regions play key roles in alpha synuclein aggregation.
Khare SD, Chinchilla P, Baum J., Free PMC Article | 06/7/2023 |
| Qualitative Evaluation of alpha-Synuclein: A Critical Step in Unravelling the Complexities of Autism Spectrum Disorder. | Qualitative Evaluation of α-Synuclein: A Critical Step in Unravelling the Complexities of Autism Spectrum Disorder.
Preethy S, Raghavan K, Ikewaki N, Abraham SJK., Free PMC Article | 06/7/2023 |
| Tunnelling nanotubes between neuronal and microglial cells allow bi-directional transfer of alpha-Synuclein and mitochondria. | Tunnelling nanotubes between neuronal and microglial cells allow bi-directional transfer of α-Synuclein and mitochondria.
Chakraborty R, Nonaka T, Hasegawa M, Zurzolo C., Free PMC Article | 05/23/2023 |
| Interplay between APP and glypican-1 processing and alpha-synuclein aggregation in undifferentiated and differentiated human neural progenitor cells. | Interplay between APP and glypican-1 processing and α-synuclein aggregation in undifferentiated and differentiated human neural progenitor cells.
Cheng F, Fransson LÅ, Mani K., Free PMC Article | 05/20/2023 |
| Mutations in alpha-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases. | Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.
Sampognaro PJ, Arya S, Knudsen GM, Gunderson EL, Sandoval-Perez A, Hodul M, Bowles K, Craik CS, Jacobson MP, Kao AW., Free PMC Article | 05/19/2023 |
| The G51D SNCA mutation generates a slowly progressive alpha-synuclein strain in early-onset Parkinson's disease. | The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson's disease.
Lau HHC, Martinez-Valbuena I, So RWL, Mehra S, Silver NRG, Mao A, Stuart E, Schmitt-Ulms C, Hyman BT, Ingelsson M, Kovacs GG, Watts JC., Free PMC Article | 05/9/2023 |