| Here we describe the cloning of the human PA receptor using a genetic complementation approach | Identification of the cellular receptor for anthrax toxin.
Bradley KA, Mogridge J, Mourez M, Collier RJ, Young JA. | 01/21/2010 |
| results indicate that TEM8 plays a positive role in endothelial cell activities related to angiogenesis | TEM8 expression stimulates endothelial cell adhesion and migration by regulating cell-matrix interactions on collagen.
Hotchkiss KA, Basile CM, Spring SC, Bonuccelli G, Lisanti MP, Terman BI. | 01/21/2010 |
| because protective antigen binds to CMG2 with much higher affinity than it does to TEM8, a lower pH is needed to attenuate CMG2 binding to allow pore formation; toxin can form pores at different points in the endocytic pathway | Receptor-specific requirements for anthrax toxin delivery into cells.
Rainey GJ, Wigelsworth DJ, Ryan PL, Scobie HM, Collier RJ, Young JA., Free PMC Article | 01/21/2010 |
| TEM8 is a new adhesion molecule linking collagen I or PA to the actin cytoskeleton | Anthrax toxin receptor 1/tumor endothelium marker 8 mediates cell spreading by coupling extracellular ligands to the actin cytoskeleton.
Werner E, Kowalczyk AP, Faundez V. | 01/21/2010 |
| ATR/TEM8 protein is highly expressed in epithelial cells, which represent the primary location for bacterial invasion. | ATR/TEM8 is highly expressed in epithelial cells lining Bacillus anthracis' three sites of entry: implications for the pathogenesis of anthrax infection.
Bonuccelli G, Sotgia F, Frank PG, Williams TM, de Almeida CJ, Tanowitz HB, Scherer PE, Hotchkiss KA, Terman BI, Rollman B, Alileche A, Brojatsch J, Lisanti MP. | 11/29/2006 |
| These results suggest that the TEM-8 vW and transmembrane domains may play an important biological role in TEM-8 related tubule formation. | TEM-8 and tubule formation in endothelial cells, its potential role of its vW/TM domains.
Rmali KA, Puntis MC, Jiang WG. | 01/21/2010 |