| G2 phase cyclin A/cdk2 controls the timing of entry into mitosis by controlling the subsequent activation of cyclin B/cdk1, but also has an unexpected role in coordinating the activation of cyclin B/cdk1 at the centrosome and in the nucleus | Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events.
De Boer L, Oakes V, Beamish H, Giles N, Stevens F, Somodevilla-Torres M, Desouza C, Gabrielli B. | 01/21/2010 |
| Over expression of H179Y-mutant p53 promoted G1 to S phase transition with enlarged cell size and increased cyclin A1 and Cdk4 expression in HELF cells. | The over-expression of p53 H179Y residue mutation causes the increase of cyclin A1 and Cdk4 expression in HELF cells.
Yang D, Qi Y, Chen Q, Wang Z, Jin X, Gao J, Fu J, Xiao X, Zhou Z. | 01/21/2010 |
| these analyses demonstrate that cyclin A1 exerts antiapoptotic functions by interacting with retinoblastoma and Ku proteins in leukemia cells. | DNA damage response involves modulation of Ku70 and Rb functions by cyclin A1 in leukemia cells.
Ji P, Bäumer N, Yin T, Diederichs S, Zhang F, Beger C, Welte K, Fulda S, Berdel WE, Serve H, Müller-Tidow C. | 01/21/2010 |
| The data implicate cyclin A1 as a downstream player in p53-dependent apoptosis and G2 arrest. | Cyclin A1 is a p53-induced gene that mediates apoptosis, G2/M arrest, and mitotic catastrophe in renal, ovarian, and lung carcinoma cells.
Rivera A, Mavila A, Bayless KJ, Davis GE, Maxwell SA., Free PMC Article | 01/21/2010 |
| cyclin A1 mediates VEGF expression in cooperation with Rb- and androgen-dependent pathways in prostate cancer | A role for cyclin A1 in mediating the autocrine expression of vascular endothelial growth factor in prostate cancer.
Wegiel B, Bjartell A, Ekberg J, Gadaleanu V, Brunhoff C, Persson JL. | 01/21/2010 |
| study provides evidence that the cyclin A1-cyclin dependent kinase 2 complex plays a role in several signaling pathways important for cell cycle control and meiosis | Identification of interaction partners and substrates of the cyclin A1-CDK2 complex.
Diederichs S, Bäumer N, Ji P, Metzelder SK, Idos GE, Cauvet T, Wang W, Möller M, Pierschalski S, Gromoll J, Schrader MG, Koeffler HP, Berdel WE, Serve H, Müller-Tidow C. | 01/21/2010 |
| CCNA1 had successive increases in its promoter activity during spermatgogensis in transgenic mice. | Successive increases in human cyclin A1 promoter activity during spermatogenesis in transgenic mice.
Müller-Tidow C, Readhead C, Cohen AH, Asotra K, Idos G, Diederichs S, Cauvet T, Yang R, Berdel WE, Serve H, Koeffler HP. | 01/21/2010 |
| Significant tumour specific methylation of cyclin A1 promoter seen in oral sqmaous cell carcinoma | Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing.
Shaw RJ, Liloglou T, Rogers SN, Brown JS, Vaughan ED, Lowe D, Field JK, Risk JM., Free PMC Article | 01/21/2010 |
| Cyclin A1 methylation was inversely related to p53 mutational status in primary tumors, and forced expression of cyclin A1 resulted in robust induction of wild-type p53 in HNSCC cell lines. | Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencing.
Tokumaru Y, Yamashita K, Osada M, Nomoto S, Sun DI, Xiao Y, Hoque MO, Westra WH, Califano JA, Sidransky D. | 01/21/2010 |
| These findings establish a novel function for cyclin A1 and CDK2 in DNA double strand break repair following radiation damage. | The cyclin A1-CDK2 complex regulates DNA double-strand break repair.
Müller-Tidow C, Ji P, Diederichs S, Potratz J, Bäumer N, Köhler G, Cauvet T, Choudary C, van der Meer T, Chan WY, Nieduszynski C, Colledge WH, Carrington M, Koeffler HP, Restle A, Wiesmüller L, Sobczak-Thépot J, Berdel WE, Serve H., Free PMC Article | 01/21/2010 |
| the level of cyclin A1 mRNA expression predicts meiotic disorders during spermatogenesis | Quantification of cyclin A1 and glyceraldehyde-3-phosphate dehydrogenase expression in testicular biopsies of infertile patients by fluorescence real-time RT-PCR.
Schrader M, Ravnik S, Müller-Tidow C, Müller M, Straub B, Diedrichs S, Serve H, Miller K. | 01/21/2010 |
| Mip/LIN-9 is required for the expression of B-Myb, and both proteins collaborate in the control of the cell cycle progression via the regulation of S phase and cyclin A, cyclin B, and CDK1 | Mip/LIN-9 regulates the expression of B-Myb and the induction of cyclin A, cyclin B, and CDK1.
Pilkinton M, Sandoval R, Song J, Ness SA, Colamonici OR. | 01/21/2010 |
| these analyses demonstrate that cyclin A1 contributes to G1 to S cell cycle progression in somatic cells. | Cyclin A1, the alternative A-type cyclin, contributes to G1/S cell cycle progression in somatic cells.
Ji P, Agrawal S, Diederichs S, Bäumer N, Becker A, Cauvet T, Kowski S, Beger C, Welte K, Berdel WE, Serve H, Müller-Tidow C. | 01/21/2010 |