| regulation of ERK1/2 by MKP-3 is countered by the complex regulation of MKP-3 by ERK1/2. | Reciprocal regulation of extracellular signal regulated kinase 1/2 and mitogen activated protein kinase phosphatase-3.
Zeliadt NA, Mauro LJ, Wattenberg EV., Free PMC Article | 01/21/2010 |
| mitogen-activated protein kinase phosphatase 3 activity is inhibited by interdomain binding | Inhibition of mitogen-activated protein kinase phosphatase 3 activity by interdomain binding.
Mark JK, Aubin RA, Smith S, Hefford MA., Free PMC Article | 01/21/2010 |
| These results indicate that intron 1 of DUSP6 plays a crucial role in transcriptional regulation of DUSP6 in a feedback loop manner responding to MAPK1 via ETS2 in human cells. | Feedback regulation of DUSP6 transcription responding to MAPK1 via ETS2 in human cells.
Furukawa T, Tanji E, Xu S, Horii A. | 01/21/2010 |
| Loss of MKP3 mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer | Loss of MKP3 mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer cells.
Chan DW, Liu VW, Tsao GS, Yao KM, Furukawa T, Chan KK, Ngan HY. | 01/21/2010 |
| WT1 transactivates another important negative regulator of the Ras/MAPK pathway, MAPK phosphatase 3 (MKP3). | WT1 induction of mitogen-activated protein kinase phosphatase 3 represents a novel mechanism of growth suppression.
Morrison DJ, Kim MK, Berkofsky-Fessler W, Licht JD., Free PMC Article | 01/21/2010 |
| even upon over-expression DUSP6 fails to inactivate ERK5, confirming that it is indeed an ERK1/2-specific DUSP | DUSP6/MKP-3 inactivates ERK1/2 but fails to bind and inactivate ERK5.
Arkell RS, Dickinson RJ, Squires M, Hayat S, Keyse SM, Cook SJ. | 01/21/2010 |
| Nuclear matrix proteins such as mutant Pyst1 and nucleophosmin 1 were downregulated, whereas eIF6 and beta-tubulin were upregulated during cell differentiation in hepatocarcinoma cells. | Alteration of nuclear matrix-intermediate filament system and differential expression of nuclear matrix proteins during human hepatocarcinoma cell differentiation.
Tang J, Niu JW, Xu DH, Li ZX, Li QF, Chen JA., Free PMC Article | 01/21/2010 |
| Hypermethylation with modification of histone deacetylation play an important role in transcriptional suppression of DUSP6 in human pancreatic cancer | Abrogation of DUSP6 by hypermethylation in human pancreatic cancer.
Xu S, Furukawa T, Kanai N, Sunamura M, Horii A. | 01/21/2010 |
| Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence. | Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence.
Kim HS, Song MC, Kwak IH, Park TJ, Lim IK. | 01/21/2010 |
| Results demonstrate that in the Korean population DUSP6 may contribute to the etiology of bipolar disorder, but not schizophrenia. | The association of DUSP6 gene with schizophrenia and bipolar disorder: its possible role in the development of bipolar disorder.
Lee KY, Ahn YM, Joo EJ, Chang JS, Kim YS. | 01/21/2010 |
| Results show that DUSP6 exerts apparent tumor-suppressive effects in vitro and suggest that DUSP6 is a strong candidate tumor suppressor gene at 12q22 locus. | Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer.
Furukawa T, Sunamura M, Motoi F, Matsuno S, Horii A., Free PMC Article | 01/21/2010 |
| cytoplasmic localization of MKP3 is mediated by a chromosome region maintenance-1 (CRM1)-dependent nuclear export pathway; the ability of MKP3 to cause the cytoplasmic retention of ERK2 requires both a functional kinase interaction motif and NES | Both nuclear-cytoplasmic shuttling of the dual specificity phosphatase MKP-3 and its ability to anchor MAP kinase in the cytoplasm are mediated by a conserved nuclear export signal.
Karlsson M, Mathers J, Dickinson RJ, Mandl M, Keyse SM. | 01/21/2010 |
| Angiotensin II-induced upregulation of MAP kinase phosphatase-3 mRNA levels mediates endothelial cell apoptosis | Angiotensin II-induced upregulation of MAP kinase phosphatase-3 mRNA levels mediates endothelial cell apoptosis.
Rössig L, Hermann C, Haendeler J, Assmus B, Zeiher AM, Dimmeler S. | 01/21/2010 |
| These results suggest the existence of an ERK1/2-driven negative feed-back regulation of ERK5 signaling in epidermal growth factor-stimulated HK-2 cells, which is mediated by MKP-3, DUSP5 and/or MKP-1. | ERK1/2-driven and MKP-mediated inhibition of EGF-induced ERK5 signaling in human proximal tubular cells.
Sarközi R, Miller B, Pollack V, Feifel E, Mayer G, Sorokin A, Schramek H. | 01/21/2010 |
| Study gives first direct evidence that the N-terminal domain of MKP3 mediates intramolecular dephosphorylation between the monomeric form of phosphorylated extracellular signal-regulated kinase and a monomer of MKP3. | Intramolecular dephosphorylation of ERK by MKP3.
Kim Y, Rice AE, Denu JM. | 01/21/2010 |
| Results suggest that the abrogation of DUSP6 is associated exclusively with progression from pancreatic intraepithelial neoplasia to the invasive ductal carcinoma. | Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas.
Furukawa T, Fujisaki R, Yoshida Y, Kanai N, Sunamura M, Abe T, Takeda K, Matsuno S, Horii A. | 01/21/2010 |