| Mannose receptor (MR) may serve as a binding and an entry site, but the MR-mediated pathway does not lead to productive HIV-1 infection. | Noninfectious entry of HIV-1 into peripheral and brain macrophages mediated by the mannose receptor.
Trujillo JR, Rogers R, Molina RM, Dangond F, McLane MF, Essex M, Brain JD., Free PMC Article | 01/21/2010 |
| reduced expression in Mycobacterium tuberculosis-infected human macrophages exhibiting enhanced cellular adhesion | Mycobacterium tuberculosis-infected human macrophages exhibit enhanced cellular adhesion with increased expression of LFA-1 and ICAM-1 and reduced expression and/or function of complement receptors, FcgammaRII and the mannose receptor.
DesJardin LE, Kaufman TM, Potts B, Kutzbach B, Yi H, Schlesinger LS. | 01/21/2010 |
| demonstrate that entry of FVIII into human dendritic cells (DC) leading to T cell activation, is mediated by mannose-terminating glycans on FVIII | A role for exposed mannosylations in presentation of human therapeutic self-proteins to CD4+ T lymphocytes.
Dasgupta S, Navarrete AM, Bayry J, Delignat S, Wootla B, André S, Christophe O, Nascimbeni M, Jacquemin M, Martinez-Pomares L, Geijtenbeek TB, Moris A, Saint-Remy JM, Kazatchkine MD, Kaveri SV, Lacroix-Desmazes S., Free PMC Article | 01/21/2010 |
| The mannose receptors on human AM may suppress select proinflammatory cytokine release and may serve to regulate the innate inflammatory responses to infectious challenge in the lungs. | Negative regulatory role of mannose receptors on human alveolar macrophage proinflammatory cytokine release in vitro.
Zhang J, Tachado SD, Patel N, Zhu J, Imrich A, Manfruelli P, Cushion M, Kinane TB, Koziel H. | 01/21/2010 |
| Endocytosis of glycosylated protein by the mannose receptor does not enhance presentation of antigen. The postulated role of the mannose receptor in presentation of glycoprotein-derived antigen is reevaluated in light of these results. | The mannose receptor fails to enhance processing and presentation of a glycoprotein antigen in transfected fibroblasts.
Napper CE, Taylor ME. | 01/21/2010 |
| MR is a binding receptor, which requires a partner to trigger phagocytosis in some specialized cells such as macrophages. | The human macrophage mannose receptor is not a professional phagocytic receptor.
Le Cabec V, Emorine LJ, Toesca I, Cougoule C, Maridonneau-Parini I. | 01/21/2010 |
| Engagement of the Mannose Receptor by mannose-capped lipoarabinomannan during the phagocytic process directs Mycobacterium tuberculosis to its initial phagosomal niche, thereby enhancing survival in human macrophages. | The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis.
Kang PB, Azad AK, Torrelles JB, Kaufman TM, Beharka A, Tibesar E, DesJardin LE, Schlesinger LS., Free PMC Article | 01/21/2010 |
| alveolar macrophage mannose receptor mediates Pneumocystis mediated NF-kB nuclear translocation and may represent an important mechanism of the host cell response to Pneumocystis infection | Pneumocystis activates human alveolar macrophage NF-kappaB signaling through mannose receptors.
Zhang J, Zhu J, Imrich A, Cushion M, Kinane TB, Koziel H., Free PMC Article | 01/21/2010 |