| Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | See all PubMed (2) articlesA pharmacogenetic study of polymorphisms in interferon pathway genes and response to interferon-alpha treatment in chronic hepatitis B patients.
Wu X, Zhu X, Zhu S, Li J, Ma J, Li Z, Li H, Liu Y. Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial.
Welzel TM, Morgan TR, Bonkovsky HL, Naishadham D, Pfeiffer RM, Wright EC, Hutchinson AA, Crenshaw AT, Bashirova A, Carrington M, Dotrang M, Sterling RK, Lindsay KL, Fontana RJ, Lee WM, Di Bisceglie AM, Ghany MG, Gretch DR, Chanock SJ, Chung RT, O'Brien TR, HALT-C Trial Group. | 05/17/2009 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Association of SARS susceptibility with single nucleic acid polymorphisms of OAS1 and MxA genes: a case-control study.
He J, Feng D, de Vlas SJ, Wang H, Fontanet A, Zhang P, Plancoulaine S, Tang F, Zhan L, Yang H, Wang T, Richardus JH, Habbema JD, Cao W, He J, Feng D, de Vlas SJ, Wang H, Fontanet A, Zhang P, Plancoulaine S, Tang F, Zhan L, Yang H, Wang T, Richardus JH, Habbema JD, Cao W., Free PMC Articles: PMC1550407, PMC1550407 | 03/13/2008 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (10) articlesVariability in the 2'-5'-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease.
Barkhash AV, Perelygin AA, Babenko VN, Myasnikova NG, Pilipenko PI, Romaschenko AG, Voevoda MI, Brinton MA. OAS1: a multiple sclerosis susceptibility gene that influences disease severity.
O'Brien M, Lonergan R, Costelloe L, O'Rourke K, Fletcher JM, Kinsella K, Sweeney C, Antonelli G, Mills KH, O'Farrelly C, Hutchinson M, Tubridy N. Dengue hemorrhagic fever is associated with polymorphisms in JAK1.
Silva LK, Blanton RE, Parrado AR, Melo PS, Morato VG, Reis EA, Dias JP, Castro JM, Vasconcelos PF, Goddard KA, Barreto ML, Reis MG, Teixeira MG. Polymorphism of OAS-1 determines liver fibrosis progression in hepatitis C by reduced ability to inhibit viral replication.
Li CZ, Kato N, Chang JH, Muroyama R, Shao RX, Dharel N, Sermsathanasawadi R, Kawabe T, Omata M. Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man.
Lim JK, Lisco A, McDermott DH, Huynh L, Ward JM, Johnson B, Johnson H, Pape J, Foster GA, Krysztof D, Follmann D, Stramer SL, Margolis LB, Murphy PM. OAS1 gene haplotype confers susceptibility to multiple sclerosis.
Fedetz M, Matesanz F, Caro-Maldonado A, Fernandez O, Tamayo JA, Guerrero M, Delgado C, López-Guerrero JA, Alcina A, Fedetz M, Matesanz F, Caro-Maldonado A, Fernandez O, Tamayo JA, Guerrero M, Delgado C, López-Guerrero JA, Alcina A. No evidence for association of OAS1 with type 1 diabetes in unaffected siblings or type 1 diabetic cases.
Smyth DJ, Cooper JD, Lowe CE, Nutland S, Walker NM, Clayton DG, Todd JA, Smyth DJ, Cooper JD, Lowe CE, Nutland S, Walker NM, Clayton DG, Todd JA. Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype?
Tessier MC, Qu HQ, Fréchette R, Bacot F, Grabs R, Taback SP, Lawson ML, Kirsch SE, Hudson TJ, Polychronakos C. Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population.
Hamano E, Hijikata M, Itoyama S, Quy T, Phi NC, Long HT, Ha LD, Ban VV, Matsushita I, Yanai H, Kirikae F, Kirikae T, Kuratsuji T, Sasazuki T, Keicho N, Hamano E, Hijikata M, Itoyama S, Quy T, Phi NC, Long HT, Ha LD, Ban VV, Matsushita I, Yanai H, Kirikae F, Kirikae T, Kuratsuji T, Sasazuki T, Keicho N. Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR.
Knapp S, Yee LJ, Frodsham AJ, Hennig BJ, Hellier S, Zhang L, Wright M, Chiaramonte M, Graves M, Thomas HC, Hill AV, Thursz MR, Knapp S, Yee LJ, Frodsham AJ, Hennig BJ, Hellier S, Zhang L, Wright M, Chiaramonte M, Graves M, Thomas HC, Hill AV, Thursz MR. | 03/13/2008 |
| Observational study of gene-environment interaction. (HuGE Navigator) | Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study.
King JK, Yeh SH, Lin MW, Liu CJ, Lai MY, Kao JH, Chen DS, Chen PJ. | 03/13/2008 |
| IL-28A and IL-29 induced mRNA expression of the antiviral proteins 2',5'-OAS and MxA was abolished by overexpression of SOCS-1 | SOCS-1 inhibits expression of the antiviral proteins 2',5'-OAS and MxA induced by the novel interferon-lambdas IL-28A and IL-29.
Brand S, Zitzmann K, Dambacher J, Beigel F, Olszak T, Vlotides G, Eichhorst ST, Göke B, Diepolder H, Auernhammer CJ. | 01/21/2010 |
| Naturally mutated residues Lys404, Pro500 and Ser471 of E17 isozyme of 2',5'-oligoadenylate synthetase from a transgenic mouse serve an essential function in maintaining the enzyme activity of the protein. | Natural mutations in a 2'-5' oligoadenylate synthetase transgene revealed residues essential for enzyme activity.
Sarkar SN, Kessler SP, Rowe TM, Pandey M, Ghosh A, Elco CP, Hartmann R, Pal S, Sen GC. | 01/21/2010 |
| role in interferon-gamma inhibition of respiratory syncytial virus infection of human epithelial cells | 2'-5' Oligoadenylate synthetase plays a critical role in interferon-gamma inhibition of respiratory syncytial virus infection of human epithelial cells.
Behera AK, Kumar M, Lockey RF, Mohapatra SS. | 01/21/2010 |
| OAS1 single nucleotide polymorphisms were significantly increased in diabetic compared with healthy siblings. | OAS1 splice site polymorphism controlling antiviral enzyme activity influences susceptibility to type 1 diabetes.
Field LL, Bonnevie-Nielsen V, Pociot F, Lu S, Nielsen TB, Beck-Nielsen H. | 01/21/2010 |
| single nucleotide polymorphisms (SNPs) identified in OAS exons in hospitalized patients with West Nile Virus infection | Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection.
Yakub I, Lillibridge KM, Moran A, Gonzalez OY, Belmont J, Gibbs RA, Tweardy DJ. | 01/21/2010 |
| Polymorphisms in the OSA1 gene is associated with outcome of hepatitis C virus infection | Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR.
Knapp S, Yee LJ, Frodsham AJ, Hennig BJ, Hellier S, Zhang L, Wright M, Chiaramonte M, Graves M, Thomas HC, Hill AV, Thursz MR, Knapp S, Yee LJ, Frodsham AJ, Hennig BJ, Hellier S, Zhang L, Wright M, Chiaramonte M, Graves M, Thomas HC, Hill AV, Thursz MR. | 01/21/2010 |
| This genetic polymorphism makes OAS1 an excellent candidate for a human gene that influences host susceptibility to viral infection. | Variation in antiviral 2',5'-oligoadenylate synthetase (2'5'AS) enzyme activity is controlled by a single-nucleotide polymorphism at a splice-acceptor site in the OAS1 gene.
Bonnevie-Nielsen V, Field LL, Lu S, Zheng DJ, Li M, Martensen PM, Nielsen TB, Beck-Nielsen H, Lau YL, Pociot F., Free PMC Article | 01/21/2010 |
| polymorphisms of two interferon-inducible genes OAS-1 and myxovirus resistance-A might affect susceptibility to the disease and progression of severe acute respiratory syndrome at each level | Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population.
Hamano E, Hijikata M, Itoyama S, Quy T, Phi NC, Long HT, Ha LD, Ban VV, Matsushita I, Yanai H, Kirikae F, Kirikae T, Kuratsuji T, Sasazuki T, Keicho N, Hamano E, Hijikata M, Itoyama S, Quy T, Phi NC, Long HT, Ha LD, Ban VV, Matsushita I, Yanai H, Kirikae F, Kirikae T, Kuratsuji T, Sasazuki T, Keicho N., Free PMC Articles: PMC7092916, PMC7092916 | 01/21/2010 |
| sequence motifs in OAS1 regulate polyadenylation | The cleavage/polyadenylation activity triggered by a U-rich motif sequence is differently required depending on the poly(A) site location at either the first or last 3'-terminal exon of the 2'-5' oligo(A) synthetase gene.
Aissouni Y, Perez C, Calmels B, Benech PD. | 01/21/2010 |
| identification of the substrate-binding sites | Identification of the substrate-binding sites of 2'-5'-oligoadenylate synthetase.
Sarkar SN, Miyagi M, Crabb JW, Sen GC. | 01/21/2010 |
| No evidence of association with either type 1 diabetic affcted or unaffected siblings in terms of relative risk. | No evidence for association of OAS1 with type 1 diabetes in unaffected siblings or type 1 diabetic cases.
Smyth DJ, Cooper JD, Lowe CE, Nutland S, Walker NM, Clayton DG, Todd JA, Smyth DJ, Cooper JD, Lowe CE, Nutland S, Walker NM, Clayton DG, Todd JA. | 01/21/2010 |
| Polymorphisms within the OAS1 gene are associated with susceptibility to severe acute respiratory syndrome. | Association of SARS susceptibility with single nucleic acid polymorphisms of OAS1 and MxA genes: a case-control study.
He J, Feng D, de Vlas SJ, Wang H, Fontanet A, Zhang P, Plancoulaine S, Tang F, Zhan L, Yang H, Wang T, Richardus JH, Habbema JD, Cao W, He J, Feng D, de Vlas SJ, Wang H, Fontanet A, Zhang P, Plancoulaine S, Tang F, Zhan L, Yang H, Wang T, Richardus JH, Habbema JD, Cao W., Free PMC Articles: PMC1550407, PMC1550407 | 01/21/2010 |
| findings indicate that the OAS1 gene polymorphisms may confer susceptibility to multiple sclerosis or serve as markers of functional variants and suggest that OAS1 activity is involved in the etiology of the disease | OAS1 gene haplotype confers susceptibility to multiple sclerosis.
Fedetz M, Matesanz F, Caro-Maldonado A, Fernandez O, Tamayo JA, Guerrero M, Delgado C, López-Guerrero JA, Alcina A, Fedetz M, Matesanz F, Caro-Maldonado A, Fernandez O, Tamayo JA, Guerrero M, Delgado C, López-Guerrero JA, Alcina A. | 01/21/2010 |