| beta-arrestin has a role in ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase | {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase.
Girnita L, Shenoy SK, Sehat B, Vasilcanu R, Girnita A, Lefkowitz RJ, Larsson O. | 01/21/2010 |
| Down- and up-regulation suggests that restoration of IGF-1R would be the result of receptor recycling and de novo synthesis and highlights its importance for T lymphocyte proliferation. | Insulin-like growth factor-1 receptor regulation in activated human T lymphocytes.
Segretin ME, Galeano A, Roldán A, Schillaci R. | 01/21/2010 |
| high expression level of insulin-like growth factor I receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric cancer | A high expression level of insulin-like growth factor I receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric cancer.
Jiang Y, Wang L, Gong W, Wei D, Le X, Yao J, Ajani J, Abbruzzese JL, Huang S, Xie K. | 01/21/2010 |
| Overexpressed and activated IGF1-R may increase the degree of transformation and motility of colon cancer cells by activating c-Src. | Insulin-like growth factor 1 receptor activates c-SRC and modifies transformation and motility of colon cancer in vitro.
Sekharam M, Nasir A, Kaiser HE, Coppola D. | 01/21/2010 |
| signaling pathways mediated by insulin-like growth factor-I receptor are required for proliferation, invasion, and VPF/VEGF expression in a pancreatic carcinoma cell line | Requirement of different signaling pathways mediated by insulin-like growth factor-I receptor for proliferation, invasion, and VPF/VEGF expression in a pancreatic carcinoma cell line.
Zeng H, Datta K, Neid M, Li J, Parangi S, Mukhopadhyay D. | 01/21/2010 |
| an interrelationship is now known to exist between the IGF and EGF receptors [review] | Signalling by the type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptor.
Adams TE, McKern NM, Ward CW. | 01/21/2010 |
| results suggest a novel function for the IGF-IR/IRS-1 pathway that involves regulation of the intracellular trafficking of Rad51 to the site of damaged DNA-a crucial step in the process of DNA repair by homologous recombination | Role of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombination.
Trojanek J, Ho T, Del Valle L, Nowicki M, Wang JY, Lassak A, Peruzzi F, Khalili K, Skorski T, Reiss K., Free PMC Article | 01/21/2010 |
| Shc and IGF-1R serve as key elements in the translocation of ERalpha to the cell membrane and in the facilitation of ERalpha-mediated rapid E2 action | The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor alpha to the plasma membrane.
Song RX, Barnes CJ, Zhang Z, Bao Y, Kumar R, Santen RJ., Free PMC Article | 01/21/2010 |
| IGFBP-3 inhibits IGF-I-mediated IGF type 1 receptor (IGF-IR) phosphorylation in 3t3 cells overexpessing human IGF1R | Matrix metalloproteinase-7 facilitates insulin-like growth factor bioavailability through its proteinase activity on insulin-like growth factor binding protein 3.
Miyamoto S, Yano K, Sugimoto S, Ishii G, Hasebe T, Endoh Y, Kodama K, Goya M, Chiba T, Ochiai A. | 01/21/2010 |
| IGF-IR and IGF-IIR antisense genes could significantly restrain the malignant behavior of human hepatoma cells and might be useful in investigating a potential route for hepatocellular carcinoma gene therapy. | Effects of insulin-like growth factors-IR and -IIR antisense gene transfection on the biological behaviors of SMMC-7721 human hepatoma cells.
Yang JM, Chen WS, Liu ZP, Luo YH, Liu WW. | 01/21/2010 |
| Ability of a monoclonal antibody to down-regulate the receptor may be an important antibody property in targeting the insulin-like growth factor-I receptor for the treatment of certain cancers. | Inhibition of the biologic response to insulin-like growth factor I in MCF-7 breast cancer cells by a new monoclonal antibody to the insulin-like growth factor-I receptor. The importance of receptor down-regulation.
Jackson-Booth PG, Terry C, Lackey B, Lopaczynska M, Nissley P. | 01/21/2010 |
| The present data suggests that the IGF-IR gene is a novel downstream target in an ATM-mediated DNA damage response pathway. | Ataxia-telangiectasia mutated gene controls insulin-like growth factor I receptor gene expression in a deoxyribonucleic acid damage response pathway via mechanisms involving zinc-finger transcription factors Sp1 and WT1.
Shahrabani-Gargir L, Pandita TK, Werner H. | 01/21/2010 |
| Breast cancer MCF-10A cells over-expressing the IGFIR formed large, misshapen acinar structures with filled lumina and disrupted apico-basal polarization. | Type I insulin-like growth factor receptor over-expression induces proliferation and anti-apoptotic signaling in a three-dimensional culture model of breast epithelial cells.
Yanochko GM, Eckhart W., Free PMC Article | 01/21/2010 |
| demonstrate significant overexpression of the IGF-IR in human pheochromocytomas | Overexpression of the insulin-like growth factor I receptor in human pheochromocytomas.
Fottner C, Minnemann T, Kalmbach S, Weber MM. | 01/21/2010 |
| The up-regulation of IGF-IR expression in hepatocytes of patients with CHC could constitute an attempt to stimulate hepatocyte regeneration. | Increased hepatic expression of insulin-like growth factor-I receptor in chronic hepatitis C.
Stefano JT, Correa-Giannella ML, Ribeiro CM, Alves VA, Massarollo PC, Machado MC, Giannella-Neto D., Free PMC Article | 01/21/2010 |
| These results demonstrate that IGF1R is downregulated by P53, and that siRNA targeting of IGF1R increases liver cancer cells sensitivity to adriamycin and promotes apoptosis. | siRNA-mediated type 1 insulin-like growth factor receptor silencing induces chemosensitization of a human liver cancer cell line with mutant P53.
Niu J, Xu Z, Li XN, Han Z. | 01/21/2010 |
| IGF I receptor is involved in apoptosis protection in human preadipocytes and adipocytes. | Inhibition of death-receptor mediated apoptosis in human adipocytes by the insulin-like growth factor I (IGF-I)/IGF-I receptor autocrine circuit.
Fischer-Posovszky P, Tornqvist H, Debatin KM, Wabitsch M. | 01/21/2010 |
| To further understand the role of the type I insulin-like growth factor (IGF) receptor (IGF1R) in cancer metastasis we inhibited signaling via IGF1R using a C-terminal-truncated IGF1R. | A dominant negative type I insulin-like growth factor receptor inhibits metastasis of human cancer cells.
Sachdev D, Hartell JS, Lee AV, Zhang X, Yee D. | 01/21/2010 |
| Activation of IGF-1R by the chimeras reflected their binding affinities whereas the phosphorylation of the two insulin receptor isoforms was more complex. | Structural determinants for high-affinity binding of insulin-like growth factor II to insulin receptor (IR)-A, the exon 11 minus isoform of the IR.
Denley A, Bonython ER, Booker GW, Cosgrove LJ, Forbes BE, Ward CW, Wallace JC. | 01/21/2010 |
| The IGF-1 Receptor genes has been inactivated by homologous gene targeting. | Insulin-like growth factor signaling in fish.
Wood AW, Duan C, Bern HA. | 01/21/2010 |
| In sedentary, clinically stable maintenance hemodialysis patients as compared to sedentary normal individuals, the mRNA levels for IGF-IEa, IGF-II, and the IGF-I receptor are decreased in vastus lateralis muscle | Skeletal muscle mRNA for IGF-IEa, IGF-II, and IGF-I receptor is decreased in sedentary chronic hemodialysis patients.
Wang H, Casaburi R, Taylor WE, Aboellail H, Storer TW, Kopple JD. | 01/21/2010 |
| IGF-IR and c-Met cooperate to induce migration and invasion of human pancreatic carcinoma cells. | Regulatory role of c-Met in insulin-like growth factor-I receptor-mediated migration and invasion of human pancreatic carcinoma cells.
Bauer TW, Somcio RJ, Fan F, Liu W, Johnson M, Lesslie DP, Evans DB, Gallick GE, Ellis LM. | 01/21/2010 |
| Differential expression of insulin receptor, IGF-IR, and IGF-I in adhesion fibroblasts may contribute to pathogenesis of fibrosis in diabetic patients. | Effects of hyperglycemia on the differential expression of insulin and insulin-like growth factor-I receptors in human normal peritoneal and adhesion fibroblasts.
Rizk NN, Saed GM, Diamond MP. | 01/21/2010 |
| Small interferin RNA downregulates this protein and inhibits growth of a breast cancer cell line in vitro and in nude mice. | Down-regulation of IGF-IR using small, interfering, hairpin RNA (siRNA) inhibits growth of human lung cancer cell line A549 in vitro and in nude mice.
Dong AQ, Kong MJ, Ma ZY, Qian JF, Xu XH. | 01/21/2010 |
| EGFR depletion induced enhancement of IGF1R ubiquitylation and degradation. | The EGF receptor interacts with the type 1 IGF receptor and regulates its stability.
Riedemann J, Takiguchi M, Sohail M, Macaulay VM. | 01/21/2010 |