is the first description of a virus-encoded PERK-specific effector and defines a new strategy by which viruses are able to maintain endoplasmic reticulum homeostasis | Maintenance of endoplasmic reticulum (ER) homeostasis in herpes simplex virus type 1-infected cells through the association of a viral glycoprotein with PERK, a cellular ER stress sensor. Mulvey M, Arias C, Mohr I., Free PMC Article | 01/21/2010 |
Translation mediated by the internal ribosome entry site of the cat-1 mRNA is regulated by glucose availability in a PERK kinase-dependent manner | Translation mediated by the internal ribosome entry site of the cat-1 mRNA is regulated by glucose availability in a PERK kinase-dependent manner. Fernandez J, Bode B, Koromilas A, Diehl JA, Krukovets I, Snider MD, Hatzoglou M. | 01/21/2010 |
data shows that pancreatic endoplasmic reti culum eIF2alpha kinase(PERK)is required to regulate expression of insulin-like growth factor-I in the liver during the neonatal period and lack of this regulation results in severe neonatal growth retardation | PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver. Li Y, Iida K, O'Neil J, Zhang P, Li S, Frank A, Gabai A, Zambito F, Liang SH, Rosen CJ, Cavener DR. | 01/21/2010 |
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. | The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Zhang P, McGrath B, Li S, Frank A, Zambito F, Reinert J, Gannon M, Ma K, McNaughton K, Cavener DR., Free PMC Article | 01/21/2010 |
PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress | PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress. Cullinan SB, Diehl JA. | 01/21/2010 |
PERK is responsible for the large increase in phosphorylated eIF2alpha and the suppression of translation early in reperfusion after transient global brain ischemia. | PERK is responsible for the increased phosphorylation of eIF2alpha and the severe inhibition of protein synthesis after transient global brain ischemia. Owen CR, Kumar R, Zhang P, McGrath BC, Cavener DR, Krause GS. | 01/21/2010 |
Data show that endoplasmic reticulum stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK knockout mice. | ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice. Huang G, Yao J, Zeng W, Mizuno Y, Kamm KE, Stull JT, Harding HP, Ron D, Muallem S. | 01/21/2010 |
regulated translation initiation controls stress-induced gene expression in mammalian cells | Regulated translation initiation controls stress-induced gene expression in mammalian cells. Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M, Ron D. | 01/21/2010 |