| kinins modulate receptor endocytosis to rapidly decrease B2R and increase B1R on the cell surface. | Kinins promote B2 receptor endocytosis and delay constitutive B1 receptor endocytosis.
Enquist J, Skröder C, Whistler JL, Leeb-Lundberg LM. | 01/21/2010 |
| The presence of AT1/B2-receptor heterodimers is involved in the hypertensive and oxidative stress states in pre-eclampsia. | [Endothelin 1 and angiotensin II in preeeclampsia].
Ariza AC, Bobadilla NA, Halhali A. | 01/21/2010 |
| Bradykinin B2 receptor exon 1 polymorphism may represent a susceptibility marker for nephropathy progression in diabetic patients. | Bradykinin B2 receptor gene polymorphism is associated with altered urinary albumin/creatinine values in diabetic patients.
Maltais I, Bachvarova M, Maheux P, Perron P, Marceau F, Bachvarov D. | 01/21/2010 |
| BK has mitogenic actions in cultured human epithelial breast cells; the activation of PKC-delta through B2 receptor acts in concert with ERK and PI3K pathways to induce cell proliferation. | Mitogenic signalling by B2 bradykinin receptor in epithelial breast cells.
Greco S, Muscella A, Elia MG, Romano S, Storelli C, Marsigliante S. | 01/21/2010 |
| B2R polymorphism has a potential role in the earlier development of chronic renal failure in susceptible individuals. | Association of the human bradykinin B2 receptor gene with chronic renal failure.
Jozwiak L, Drop A, Buraczynska K, Ksiazek P, Mierzicki P, Buraczynska M. | 01/21/2010 |
| polymorphism (-58 T/C) in the promoter region of BDKRB might be a risk factor and might have a synergetic effect with the ACE for LVH in hypertensives, but it is not associated with hypertension in the Japanese population | Relationship of bradykinin B2 receptor gene polymorphism with essential hypertension and left ventricular hypertrophy.
Fu Y, Katsuya T, Matsuo A, Yamamoto K, Akasaka H, Takami Y, Iwashima Y, Sugimoto K, Ishikawa K, Ohishi M, Rakugi H, Ogihara T. | 01/21/2010 |
| Susceptibility to develop cough is associated with a genetic variant of the bradykinin B2 receptor promoter. | Association of polymorphisms of the renin-angiotensin system and bradykinin B2 receptor with ACE-inhibitor-related cough.
Mukae S, Itoh S, Aoki S, Iwata T, Nishio K, Sato R, Katagiri T. | 01/21/2010 |
| Blood pressure in patients with primary aldosteronism is influenced by bradykinin B(2) receptor polymorphism. | Blood pressure in patients with primary aldosteronism is influenced by bradykinin B(2) receptor and alpha-adducin gene polymorphisms.
Mulatero P, Williams TA, Milan A, Paglieri C, Rabbia F, Fallo F, Veglio F. | 01/21/2010 |
| Bradykinin is a powerful spasmogen via B(2) receptor activation in the normal and, especially, in the inflamed human gallbladder. | Bradykinin B2 receptors mediate contraction in the normal and inflamed human gallbladder in vitro.
Trevisani M, Amadesi S, Schmidlin F, Poblete MT, Bardella E, Maggiore B, Harrison S, Figueroa CD, Tognetto M, Navarra G, Turini A, Bunnett NW, Geppetti P, De Giorgio R. | 01/21/2010 |
| B2R is constitutively targeted to caveolae-related lipid rafts in HEK293 cells and appears to shuttle the agonist through these domains, whereas B1R may be there by default. | Human B1 and B2 bradykinin receptors and their agonists target caveolae-related lipid rafts to different degrees in HEK293 cells.
Lamb ME, Zhang C, Shea T, Kyle DJ, Leeb-Lundberg LM. | 01/21/2010 |
| Importantly, receptor sialylation and N-glycosylation participate with disulfide bonding in the stabilization of the cell surface human B2 receptor dimers. | Human bradykinin B2 receptor sialylation and N-glycosylation participate with disulfide bonding in surface receptor dimerization.
Michineau S, Alhenc-Gelas F, Rajerison RM. | 01/21/2010 |
| B(2) receptor activation results in signaling via at least dual pathways - G(s)- and G(q)-mediated signaling. | Optical biosensor provides insights for bradykinin B(2) receptor signaling in A431 cells.
Fang Y, Li GG, Peng J. | 01/21/2010 |
| the C-58T B2R gene polymorphism is not associated with different levels of insulin resistance within a population of obese patients. | Bradykinin B2 receptor gene C-58T polymorphism and insulin resistance. A study on obese patients.
Fallo F, Mulatero P, Vettor R, Scarda A, Della Mea P, Morello F, Veglio F, Williams TA. | 01/21/2010 |
| Bradykinin can also induce antimitogenic effects using an alternative signal transduction pathway for the B2 receptor. | [30 years: Happy birthday, GPCR. The bradykinin B2 receptor: an alternative and antiproliferative pathway].
Duchêne J, Schanstra J, Cellier E, Bascands JL, Girolami JP. | 01/21/2010 |
| the C-terminal domain participates intimately in the efficacy of B1R and B2R G(q/11) coupling by contributing both positive and negative regulatory epitopes. | Negative and positive regulatory epitopes in the C-terminal domains of the human B1 and B2 bradykinin receptor subtypes determine receptor coupling efficacy to G(q/11)-mediated [correction of G(9/11)-mediated] phospholipase Cbeta activity.
Kang DS, Leeb-Lundberg LM. | 01/21/2010 |
| Data show that mechanical perturbation of the plasma membrane leads to ligand-independent conformational transitions in the bradykinin B2 G protein-coupled receptor. | G protein-coupled receptors sense fluid shear stress in endothelial cells.
Chachisvilis M, Zhang YL, Frangos JA., Free PMC Article | 01/21/2010 |
| Two cysteine residues located in the carboxyterminal domain of the bradykinin B2 receptor are palmitoylated and play a critical role in the response of the receptor to ligand binding. | Palmitoylation of the human bradykinin B2 receptor influences ligand efficacy.
Pizard A, Blaukat A, Michineau S, Dikic I, Müller-Esterl W, Alhenc-Gelas F, Rajerison RM. | 01/21/2010 |
| Exon 1 polymorphism of the B2BKR gene does not influence the clinical status of patients with hereditary angioedema. | Exon 1 polymorphism of the B2BKR gene does not influence the clinical status of patients with hereditary angioedema.
Freiberger T, Vyskocilová M, Kolárová L, Kuklínek P, Krystůfková O, Lahodná M, Hanzlíková J, Litzman J. | 01/21/2010 |
| Kinin B1 and B2 receptors synergistically potentiate IL-1- and TNFalpha-induced PG biosynthesis in osteoblasts by a mechanism involving increased levels of COX-2, resulting in increased RANKL | Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression.
Brechter AB, Lerner UH. | 01/21/2010 |