| A single troponin I value at 3 days from symptom onset is a better predictor of infarct size compared to peak values and CK-MB. | Predictive value of cardiac troponin-I compared to creatine kinase-myocardial band for the assessment of infarct size as measured by cardiac magnetic resonance.
Di Chiara A, Dall'Armellina E, Badano LP, Meduri S, Pezzutto N, Fioretti PM. | 10/23/2010 |
| Phosphocreatine metabolism in the normal appearing white matter in multiple sclerosis is impaired due to decreased CK-B levels. | Reduced creatine kinase B activity in multiple sclerosis normal appearing white matter.
Steen C, Wilczak N, Hoogduin JM, Koch M, De Keyser J., Free PMC Article | 09/13/2010 |
| The correlation of CK-BB as a disease biomarker in both CNS and peripheral tissues from Huntington's disease mice and patients may provide a powerful means to assess disease progression and prognosis. | Reduced creatine kinase as a central and peripheral biomarker in Huntington's disease.
Kim J, Amante DJ, Moody JP, Edgerly CK, Bordiuk OL, Smith K, Matson SA, Matson WR, Scherzer CR, Rosas HD, Hersch SM, Ferrante RJ., Free PMC Article | 08/16/2010 |
| This protein has been found differentially expressed in the Wernicke's Area from patients with schizophrenia. | Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation.
Martins-de-Souza D, Gattaz WF, Schmitt A, Novello JC, Marangoni S, Turck CW, Dias-Neto E., Free PMC Article | 05/29/2009 |
| Three structural aspects of human-brain-type-creatine-kinase were identified by X-ray crystallography: the ligand-free-form at 2.2A; the ADP-Mg2+, nitrate, and creatine complex (transition-state-analogue complex; TSAC); and the ADP-Mg2+-complex at 2.0A. | Structural studies of human brain-type creatine kinase complexed with the ADP-Mg2+-NO3- -creatine transition-state analogue complex.
Bong SM, Moon JH, Nam KH, Lee KS, Chi YM, Hwang KY. | 01/21/2010 |
| Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia. | Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
Martins-de-Souza D, Gattaz WF, Schmitt A, Rewerts C, Maccarrone G, Dias-Neto E, Turck CW. | 01/28/2009 |
| The Tat-CK fusion protein markedly increased endogenous CK activity levels within PC12 cells. | HIV-1 Tat-mediated protein transduction of human brain creatine kinase into PC12 cells.
Jeong MS, Kim DW, Lee MJ, Lee YP, Kim SY, Lee SH, Jang SH, Lee KS, Park J, Kang TC, Cho SW, Kwon OS, Eum WS, Choi SY. | 01/21/2010 |
| Data show that dose-response inactivation by 4HNE (4-hydroxynonenal) of hBAT (human bile acid CoA:amino acid N-acyltransferase) and CKBB (cytosolic brain isoform of creatine kinase) is associated with site-specific modifications. | High-resolution mass spectrometry analysis of protein oxidations and resultant loss of function.
Barnes S, Shonsey EM, Eliuk SM, Stella D, Barrett K, Srivastava OP, Kim H, Renfrow MB., Free PMC Article | 01/21/2010 |
| Using a yeast 2-hybrid it was discovered that the C-terminal domain of KCC3, that is lost in most hereditary motor and sensory neuropathy with agenesis of the corpus callosum-causing mutations, directly interacts with brain-specific creatine kinase. | HMSN/ACC truncation mutations disrupt brain-type creatine kinase-dependant activation of K+/Cl- co-transporter 3.
Salin-Cantegrel A, Shekarabi M, Holbert S, Dion P, Rochefort D, Laganière J, Dacal S, Hince P, Karemera L, Gaspar C, Lapointe JY, Rouleau GA. | 01/21/2010 |
| Autoantibodies to EsteD and BB-CK produced in experimental autoimmune uveoretinitis -induced mice were also detected in some endogenous uveitis patients, suggesting that these proteins might be autoantigens. | Proteomic surveillance of retinal autoantigens in endogenous uveitis: implication of esterase D and brain-type creatine kinase as novel autoantigens.
Okunuki Y, Usui Y, Kezuka T, Hattori T, Masuko K, Nakamura H, Yudoh K, Goto H, Usui M, Nishioka K, Kato T, Takeuchi M., Free PMC Article | 01/21/2010 |
| The asymmetric unit contained two molecules of CKB, giving a crystal volume per protein mass (Vm) of 1.80 A3 Da-1 and a solvent content of 31.6%. | Overexpression, purification, and preliminary X-ray crystallographic analysis of human brain-type creatine kinase.
Bong SM, Moon JH, Jang EH, Lee KS, Chi YM. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6.
Haines JL, Schnetz-Boutaud N, Schmidt S, Scott WK, Agarwal A, Postel EA, Olson L, Kenealy SJ, Hauser M, Gilbert JR, Pericak-Vance MA. | 03/13/2008 |
| 2D fingerprinting & mass spectrometry reveal specific targets of protein oxidation in Alzheimer's disease brain, including creatine kinase BB, suggesting involvement of oxidatively modified proteins in neurodegeneration. | Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.
Castegna A, Aksenov M, Aksenova M, Thongboonkerd V, Klein JB, Pierce WM, Booze R, Markesbery WR, Butterfield DA. | 01/21/2010 |
| GM130 and BB-CK co-localize specifically in a transient fashion during early prophase of mitosis, when GM130 plays an important role in Golgi fragmentation that starts also at early prophase. | Brain-type creatine kinase BB-CK interacts with the Golgi Matrix Protein GM130 in early prophase.
Bürklen TS, Hirschy A, Wallimann T. | 01/21/2010 |
| Expression of CKB mRNA and CK-B sometimes occurred in blastic transformation of the hematopoietic system | Increased creatine kinase BB activity and CKB mRNA expression in patients with hematologic disorders: relation to methylation status of the CKB promoter.
Ishikawa J, Taniguchi T, Takeshita A, Maekawa M. | 01/21/2010 |
| CKB was expressed in 78% of colon tumors | Altered expression and localization of creatine kinase B, heterogeneous nuclear ribonucleoprotein F, and high mobility group box 1 protein in the nuclear matrix associated with colon cancer.
Balasubramani M, Day BW, Schoen RE, Getzenberg RH. | 01/21/2010 |