| IL-10 is a target for let-7c. | Altered let-7 expression in Myasthenia gravis and let-7c mediated regulation of IL-10 by directly targeting IL-10 in Jurkat cells.
Jiang L, Cheng Z, Qiu S, Que Z, Bao W, Jiang C, Zou F, Liu P, Liu J. | 01/26/2013 |
| The miRNA let-7c expression was markedly up-regulated in ox-LDL induced apoptotic human umbilical cord vein endothelial cells | MicroRNA let-7c inhibits Bcl-xl expression and regulates ox-LDL-induced endothelial apoptosis.
Qin B, Xiao B, Liang D, Li Y, Jiang T, Yang H. | 12/29/2012 |
| Results indicate that microRNA let-7c is downregulated in prostate cancer (PCa) and functions as a tumor suppressor, and is a potential therapeutic target for PCa. | MicroRNA let-7c is downregulated in prostate cancer and suppresses prostate cancer growth.
Nadiminty N, Tummala R, Lou W, Zhu Y, Shi XB, Zou JX, Chen H, Zhang J, Chen X, Luo J, deVere White RW, Kung HJ, Evans CP, Gao AC., Free PMC Article | 09/1/2012 |
| members of the oncomir miR-17-92 cluster were upregulated, but themiR-125b/miR-99a/let-7c, miR-106b/miR-93/miR-25 and miR-212/miR-132 clusters are also coordinately regulated either by stromal cell contact alone or by CD154 | Stromal cells and CD40 ligand (CD154) alter the miRNome and induce miRNA clusters including, miR-125b/miR-99a/let-7c and miR-17-92 in chronic lymphocytic leukaemia.
Willimott S, Wagner SD. | 07/7/2012 |
| let-7c microRNA may play a role in regulating hepatocellular carcinoma cell differentiation. | Let-7c microRNA expression and clinical significance in hepatocellular carcinoma.
Zhu XM, Wu LJ, Xu J, Yang R, Wu FS. | 05/26/2012 |
| MicroRNA let-7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells. | MicroRNA let-7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells.
Nadiminty N, Tummala R, Lou W, Zhu Y, Zhang J, Chen X, eVere White RW, Kung HJ, Evans CP, Gao AC., Free PMC Article | 03/3/2012 |
| Down-regulation of miR-let7c is associated with prostate cancer metastasis. | Change in expression of miR-let7c, miR-100, and miR-218 from high grade localized prostate cancer to metastasis.
Leite KR, Sousa-Canavez JM, Reis ST, Tomiyama AH, Camara-Lopes LH, Sañudo A, Antunes AA, Srougi M. | 10/1/2011 |
| Compared to common acquired nevi, mir-125b was found to be significantly downregulated, and let-7c was significantly upregulated in atypic nevi. | The microRNA molecular signature of atypic and common acquired melanocytic nevi: differential expression of miR-125b and let-7c.
Holst LM, Kaczkowski B, Glud M, Futoma-Kazmierczak E, Hansen LF, Gniadecki R. | 07/30/2011 |
| miRNA expression pattern may serve as biomarker of human renal allograft status | MicroRNA expression profiles predictive of human renal allograft status.
Anglicheau D, Sharma VK, Ding R, Hummel A, Snopkowski C, Dadhania D, Seshan SV, Suthanthiran M., Free PMC Article | 01/21/2010 |