| miR-26a and related pathways, such as PRKCD, play an important role in cell cycle control of ACTH pituitary cells, opening new therapeutic possibilities for the treatment of persistent/recurrent Cushing's disease. | miR-26a plays an important role in cell cycle regulation in ACTH-secreting pituitary adenomas by modulating protein kinase Cδ.
Gentilin E, Tagliati F, Filieri C, Molè D, Minoia M, Rosaria Ambrosio M, Degli Uberti EC, Zatelli MC., Free PMC Article | 06/29/2013 |
| miR-26a may be involved in regulation of anoikis-resistance of esophageal adenocarcinoma cells. | MiR-26a regulates cell cycle and anoikis of human esophageal adenocarcinoma cells through Rb1-E2F1 signaling pathway.
Zhang YF, Zhang AR, Zhang BC, Rao ZG, Gao JF, Lv MH, Wu YY, Wang SM, Wang RQ, Fang DC. | 06/22/2013 |
| Our investigation of the mechanisms underlying the decrease in miR-26a in this lymphoma revealed novel evidence that STAT3, a major downstream substrate of NPM-ALK tyrosine kinase activity, suppresses MIR26A1 gene expression. | NPM-ALK up-regulates iNOS expression through a STAT3/microRNA-26a-dependent mechanism.
Zhu H, Vishwamitra D, Curry CV, Manshouri R, Diao L, Khan A, Amin HM., Free PMC Article | 06/15/2013 |
| MicroRNA-26a target E2F7 sustains cell proliferation and inhibits monocytic differentiation of acute myeloid leukemia cells. | The microRNA-26a target E2F7 sustains cell proliferation and inhibits monocytic differentiation of acute myeloid leukemia cells.
Salvatori B, Iosue I, Mangiavacchi A, Loddo G, Padula F, Chiaretti S, Peragine N, Bozzoni I, Fazi F, Fatica A., Free PMC Article | 06/1/2013 |
| miR-26a expression inhibited the expression of enhancer of zeste homolog 2 and transactivated downstream target genes, which suggests that EZH2 is a potential target of miR-26a; miR-26a plays an important role as an anti-oncogene in the molecular mechanism of lung cancer | MicroRNA-26a regulates tumorigenic properties of EZH2 in human lung carcinoma cells.
Dang X, Ma A, Yang L, Hu H, Zhu B, Shang D, Chen T, Luo Y. | 11/24/2012 |
| Our study demonstrated that miR-26a enhanced lung cancer cell metastasis potential via modulation of metastasis-related gene expression, and activation of AKT pathway by PTEN suppression | MiR-26a enhances metastasis potential of lung cancer cells via AKT pathway by targeting PTEN.
Liu B, Wu X, Liu B, Wang C, Liu Y, Zhou Q, Xu K. | 11/17/2012 |
| Data indicate that miR-15a, miR-16, miR-26ab, miR-196ab and Let-7a as potential HMGA1 and HMGA2-targeting miRNAs. | Downregulation of HMGA-targeting microRNAs has a critical role in human pituitary tumorigenesis.
Palmieri D, D'Angelo D, Valentino T, De Martino I, Ferraro A, Wierinckx A, Fedele M, Trouillas J, Fusco A. | 11/3/2012 |
| trastuzumab modulates the expression of a subset of microRNAs, including miR-26a and miR-30b | Trastuzumab produces therapeutic actions by upregulating miR-26a and miR-30b in breast cancer cells.
Ichikawa T, Sato F, Terasawa K, Tsuchiya S, Toi M, Tsujimoto G, Shimizu K., Free PMC Article | 09/1/2012 |
| miRNAs (miR-26a1/2 and miR-26b) downregulate BDNF expression and the presence of the variant alleles of two single nucleotide polymorphisms (rs11030100 and rs11030099) mapping in BDNF 3'UTR specifically abrogates miRNAs targeting. | Brain derived neurotrophic factor (BDNF) expression is regulated by microRNAs miR-26a and miR-26b allele-specific binding.
Caputo V, Sinibaldi L, Fiorentino A, Parisi C, Catalanotto C, Pasini A, Cogoni C, Pizzuti A., Free PMC Article | 09/1/2012 |
| Silencing of MEN1 mRNA resulted in a down regulation of miR-26a and chromatin immunoprecipitation showed that menin occupies the miR-26-a gene promoter, thus inducing gene expression. | The regulatory network menin-microRNA 26a as a possible target for RNA-based therapy of bone diseases.
Luzi E, Marini F, Tognarini I, Galli G, Falchetti A, Brandi ML. | 07/28/2012 |
| hAFP-TERT dual promoter-mediated miR-26a expression could specifically exert potential antitumor activity and provide a novel targeting approach for cancer therapy. | Tumor-specific expression of microRNA-26a suppresses human hepatocellular carcinoma growth via cyclin-dependent and -independent pathways.
Chen L, Zheng J, Zhang Y, Yang L, Wang J, Ni J, Cui D, Yu C, Cai Z., Free PMC Article | 02/11/2012 |
| MiRNA-26a promotes vascular smooth muscle cell proliferation while inhibiting cellular differentiation and apoptosis, and alters TGF-beta pathway signaling. | MicroRNA-26a is a novel regulator of vascular smooth muscle cell function.
Leeper NJ, Raiesdana A, Kojima Y, Chun HJ, Azuma J, Maegdefessel L, Kundu RK, Quertermous T, Tsao PS, Spin JM., Free PMC Article | 03/5/2011 |
| RalA interaction with the Exo84 but not Sec5 exocyst component was necessary for supporting anchorage-independent growth, whereas RalB interaction with Sec5 but not Exo84 was necessary for inhibition of anchorage-independent growth | MiR-26a inhibits cell growth and tumorigenesis of nasopharyngeal carcinoma through repression of EZH2.
Lu J, He ML, Wang L, Chen Y, Liu X, Dong Q, Chen YC, Peng Y, Yao KT, Kung HF, Li XP. | 02/5/2011 |
| miR-26a functionally antagonizes human breast carcinogenesis by targeting MTDH and EZH2. | Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer.
Zhang B, Liu XX, He JR, Zhou CX, Guo M, He M, Li MF, Chen GQ, Zhao Q. | 01/29/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic polymorphisms in the precursor MicroRNA flanking region and non-small cell lung cancer survival.
Hu Z, Shu Y, Chen Y, Chen J, Dong J, Liu Y, Pan S, Xu L, Xu J, Wang Y, Dai J, Ma H, Jin G, Shen H. | 12/5/2010 |
| Study unveils that miR-26a is a mechanosensitive gene, and it plays an important role in the regulation of HASMC hypertrophy. | Mechanical stretch up-regulates microRNA-26a and induces human airway smooth muscle hypertrophy by suppressing glycogen synthase kinase-3β.
Mohamed JS, Lopez MA, Boriek AM., Free PMC Article | 10/4/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Role of primary miRNA polymorphic variants in metastatic colon cancer patients treated with 5-fluorouracil and irinotecan.
Boni V, Zarate R, Villa JC, Bandrés E, Gomez MA, Maiello E, Garcia-Foncillas J, Aranda E. | 09/15/2010 |
| demonstrated a role for miR-26a, miR-145 and miR-26a in TRAIL-induced apoptosis. | Systematic analysis of off-target effects in an RNAi screen reveals microRNAs affecting sensitivity to TRAIL-induced apoptosis.
Sudbery I, Enright AJ, Fraser AG, Dunham I., Free PMC Article | 05/31/2010 |
| Results suggest that miRNAs -26a, -34a, -145, and let-7b may modulate expression of IFN-beta, thereby influencing innate immunity from the earliest responses to viral infection. | MicroRNA regulation of IFN-beta protein expression: rapid and sensitive modulation of the innate immune response.
Witwer KW, Sisk JM, Gama L, Clements JE., Free PMC Article | 05/10/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | See all PubMed (3) articlesGenetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma.
Lin J, Horikawa Y, Tamboli P, Clague J, Wood CG, Wu X. Genetic variation in MicroRNA genes and risk of oral premalignant lesions.
Clague J, Lippman SM, Yang H, Hildebrandt MA, Ye Y, Lee JJ, Wu X. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk.
Ye Y, Wang KK, Gu J, Yang H, Lin J, Ajani JA, Wu X. | 12/2/2009 |
| In patients with hepatocellular carcinoma, the expression of miR-26a and miR-26b in nontumor liver tissue was higher in women than in men. The miR-26 expression status of patients is associated with survival and response to therapy with interferon alfa. | MicroRNA expression, survival, and response to interferon in liver cancer.
Ji J, Shi J, Budhu A, Yu Z, Forgues M, Roessler S, Ambs S, Chen Y, Meltzer PS, Croce CM, Qin LX, Man K, Lo CM, Lee J, Ng IO, Fan J, Tang ZY, Sun HC, Wang XW., Free PMC Article | 01/21/2010 |
| Zcchc11 fine tunes IL-6 production by uridylating miR-26a. | Zcchc11-dependent uridylation of microRNA directs cytokine expression.
Jones MR, Quinton LJ, Blahna MT, Neilson JR, Fu S, Ivanov AR, Wolf DA, Mizgerd JP., Free PMC Article | 01/21/2010 |
| MYC stimulates EZH2 expression by repression of its negative regulator miR-26a | MYC stimulates EZH2 expression by repression of its negative regulator miR-26a.
Sander S, Bullinger L, Klapproth K, Fiedler K, Kestler HA, Barth TF, Möller P, Stilgenbauer S, Pollack JR, Wirth T. | 01/21/2010 |