| In solid ameloblastoma, positive correlations were observed between the stromal and parenchymal expression of BMP-2 and between the stromal expression of BMP-2 and BMP-4, as well as between the stromal expression of BMPR-II and BMP-4 and the stromal and parenchymal expression of BMPR-II. | Immunoexpression of BMP-2 and BMP-4 and their receptors, BMPR-IA and BMPR-II, in ameloblastomas and adenomatoid odontogenic tumors.
Nascimento MA, Nonaka CF, Barboza CA, Freitas RA, Pereira Pinto L, Souza LB. | 04/29/2017 |
| Data show that protein kinase LKB1 physically interacts with BMP type I receptors and requires Smad7 protein to promote downregulation of the receptor. | The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling.
Raja E, Tzavlaki K, Vuilleumier R, Edlund K, Kahata K, Zieba A, Morén A, Watanabe Y, Voytyuk I, Botling J, Söderberg O, Micke P, Pyrowolakis G, Heldin CH, Moustakas A., Free PMC Article | 12/17/2016 |
| BMPR1A(+) ASCs show an enhanced ability for adipogenesis in vitro, as shown by gene expression and histological staining. | Enrichment of Adipose-Derived Stromal Cells for BMPR1A Facilitates Enhanced Adipogenesis.
Zielins ER, Paik K, Ransom RC, Brett EA, Blackshear CP, Luan A, Walmsley GG, Atashroo DA, Senarath-Yapa K, Momeni A, Rennert R, Sorkin M, Seo EY, Chan CK, Gurtner GC, Longaker MT, Wan DC., Free PMC Article | 11/5/2016 |
| Duplication of 10q22.3-q23.3 encompassing BMPR1A gene is associated with congenital heart disease, microcephaly, and mild intellectual disability | Duplication of 10q22.3-q23.3 encompassing BMPR1A and NGR3 associated with congenital heart disease, microcephaly, and mild intellectual disability.
Tang M, Yang YF, Xie L, Chen JL, Zhang WZ, Wang J, Zhao TL, Yang JF, Tan ZP. | 10/22/2016 |
| Authors analyzed human databases from TCGA and survival data from microarrays to confirm BMPR1a tumor promoting functions, and found that high BMPR1a gene expression correlates with decreased survival regardless of molecular breast cancer subtype. | Deletion of the BMP receptor BMPR1a impairs mammary tumor formation and metastasis.
Pickup MW, Hover LD, Guo Y, Gorska AE, Chytil A, Novitskiy SV, Moses HL, Owens P., Free PMC Article | 08/6/2016 |
| About half of BMPR1A-related polyps displayed loss of heterozygosity, predominantly in the epithelial compartment, compatible with BMPR1A acting as a tumour suppressor gene. | Somatic alterations in juvenile polyps from BMPR1A and SMAD4 mutation carriers.
Blatter RH, Plasilova M, Wenzel F, Gokaslan ST, Terracciano L, Ashfaq R, Heinimann K. | 04/30/2016 |
| Results support a novel role for miR-885-3p in tumor angiogenesis by targeting BMPR1A, which regulates a proangiogenic factor. | MicroRNA-885-3p inhibits the growth of HT-29 colon cancer cell xenografts by disrupting angiogenesis via targeting BMPR1A and blocking BMP/Smad/Id1 signaling.
Xiao F, Qiu H, Cui H, Ni X, Li J, Liao W, Lu L, Ding K. | 06/27/2015 |
| Decreased expression of BMPR1A was associated malignant gallbladder lesions. | Association of BDNF and BMPR1A with clinicopathologic parameters in benign and malignant gallbladder lesions.
Xiong L, Deng X, Wen Y, Yang Z, Miao X., Free PMC Article | 04/18/2015 |
| The mRNA/protein expressions of BMPR1alpha was higher in the stenotic colon segment tissue than in the normal colon segment tissue of Hirschsrung disease patients. | Differential expressions of BMPR1α, ACTN4α and FABP7 in Hirschsprung disease.
Wang W, Su Z, Chen D, Mi J, Gao H., Free PMC Article | 02/28/2015 |
| High BMPR1A expression is associated with glioma tumorigenesis. | miR-656 inhibits glioma tumorigenesis through repression of BMPR1A.
Guo M, Jiang Z, Zhang X, Lu D, Ha AD, Sun J, Du W, Wu Z, Hu L, Khadarian K, Shen J, Lin Z. | 02/21/2015 |
| Data show that USP15 enhances BMP-induced phosphorylation of SMAD1 by interacting with and deubiquitylating ALK3. | USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling.
Herhaus L, Al-Salihi MA, Dingwell KS, Cummins TD, Wasmus L, Vogt J, Ewan R, Bruce D, Macartney T, Weidlich S, Smith JC, Sapkota GP., Free PMC Article | 01/10/2015 |
| This is the first case report to document coding exon 3 duplication in the BMPR1A gene in a patient with juvenile polyposis syndrome. | Identification of coding exon 3 duplication in the BMPR1A gene in a patient with juvenile polyposis syndrome.
Yamaguchi J, Nagayama S, Chino A, Sakata A, Yamamoto N, Sato Y, Ashihara Y, Kita M, Nomura S, Ishikawa Y, Igarashi M, Ueno M, Arai M. | 01/3/2015 |
| results provide evidence that HFE induces hepcidin expression via the BMP pathway: HFE interacts with ALK3 to stabilize ALK3 protein and increase ALK3 expression at the cell surface. | HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression.
Wu XG, Wang Y, Wu Q, Cheng WH, Liu W, Zhao Y, Mayeur C, Schmidt PJ, Yu PB, Wang F, Xia Y., Free PMC Article | 10/18/2014 |
| BMP15 down-regulates StAR expression and decreases progesterone production in human granulosa cells, likely via ALK3-mediated SMAD1/5/8 signaling. | BMP15 suppresses progesterone production by down-regulating StAR via ALK3 in human granulosa cells.
Chang HM, Cheng JC, Klausen C, Leung PC., Free PMC Article | 08/9/2014 |
| BMPR1a and BMPR2 are downregulated in cardiac remodeling and heart failure | Expression of bone morphogenetic protein 4 and its receptors in the remodeling heart.
Wu X, Sagave J, Rutkovskiy A, Haugen F, Baysa A, Nygård S, Czibik G, Dahl CP, Gullestad L, Vaage J, Valen G. | 04/19/2014 |
| Bone morphogenetic protein receptor type 1A missense mutations occurring in patients with juvenile polyposis affected cellular localization in an in vitro model. | BMPR1A mutations in juvenile polyposis affect cellular localization.
Howe JR, Dahdaleh FS, Carr JC, Wang D, Sherman SK, Howe JR., Free PMC Article | 03/22/2014 |
| findings show that a reduction in the expression of BMPRIA is associated with a poorer prognosis in pancreatic cancer | Reduced expression of bone morphogenetic protein receptor IA in pancreatic cancer is associated with a poor prognosis.
Voorneveld PW, Stache V, Jacobs RJ, Smolders E, Sitters AI, Liesker A, Korkmaz KS, Lam SM, De Miranda NF, Morreau H, Kodach LL, Hardwick JC., Free PMC Article | 12/7/2013 |
| BMP receptor antagonists and silencing of BMP type I receptors with siRNA induced cell death, inhibited cell growth, and caused a significant decrease in the expression of inhibitor of differentiation (Id1, Id2, and Id3) family members. | Bone morphogenetic protein type I receptor antagonists decrease growth and induce cell death of lung cancer cell lines.
Langenfeld E, Hong CC, Lanke G, Langenfeld J., Free PMC Article | 10/26/2013 |
| Seventy-seven patients (13%) were found to have colorectal polyposis-associated mutations, including 20 in BMPR1A (3.3%) | Prevalence of germline PTEN, BMPR1A, SMAD4, STK11, and ENG mutations in patients with moderate-load colorectal polyps.
Ngeow J, Heald B, Rybicki LA, Orloff MS, Chen JL, Liu X, Yerian L, Willis J, Lehtonen HJ, Lehtonen R, Mester JL, Moline J, Burke CA, Church J, Aaltonen LA, Eng C., Free PMC Article | 08/3/2013 |
| Results suggest that rs7922846 BMPR1A polymorphism may account for subtle variation in kidney size at birth, reflecting congenital nephron endowment. | Association of BMPR1A polymorphism, but not BMP4, with kidney size in full-term newborns.
Kaczmarczyk M, Goracy I, Loniewska B, Kuprjanowicz A, Binczak-Kuleta A, Clark JS, Ciechanowicz A., Free PMC Article | 07/27/2013 |
| lack of associations between LVM, values of blood pressure, and the BMP4, BMPR1A, BMPR1B, and ACVR1 genotypes | Common genetic variants of the BMP4, BMPR1A, BMPR1B, and ACVR1 genes, left ventricular mass, and other parameters of the heart in newborns.
Gorący I, Safranow K, Dawid G, Skonieczna-Żydecka K, Kaczmarczyk M, Gorący J, Loniewska B, Ciechanowicz A. | 07/20/2013 |
| These data support the role of BMPR-1A as an indicator ofosteoarthritis progression in human knees with circumscribed cartilage lesions. | Expression of BMP-receptor type 1A correlates with progress of osteoarthritis in human knee joints with focal cartilage lesions.
Schmal H, Pilz IH, Mehlhorn AT, Dovi-Akue D, Kirchhoff C, Südkamp NP, Gerlach U, Niemeyer P. | 04/6/2013 |
| Crystals of GDF5 and BMP receptor IA complex belonged to a monoclinic space group: either I2, with unit-cell parameters a = 63.81, b = 62.85, c = 124.99 A, beta = 95.9 degrees , or C2, with unit-cell parameters a = 132.17, b = 62.78, c = 63.53 A, beta = 112.8 degrees | Purification, crystallization and preliminary data analysis of the ligand-receptor complex of the growth and differentiation factor 5 variant R57A (GDF5R57A) and BMP receptor IA (BRIA).
Nickel J, Kotzsch A, Sebald W, Mueller TD., Free PMC Article | 11/24/2012 |
| generation of TGF-beta and BMP receptor homo- and hetero-oligomers and its roles as a mechanism capable of fast regulation of signaling by these crucial cytokines [review] | Oligomeric interactions of TGF-β and BMP receptors.
Ehrlich M, Gutman O, Knaus P, Henis YI. | 09/22/2012 |
| analysis of promiscuity and specificity in BMP receptor activation [review] | Promiscuity and specificity in BMP receptor activation.
Mueller TD, Nickel J. | 09/22/2012 |