| consistent with the hypothesis that mutant alpha-synuclein disrupts vesicular dopamine compartmentalization, this effect was diminished in cells expressing mutant alpha-synuclein | G209A mutant alpha synuclein expression specifically enhances dopamine induced oxidative damage.
Orth M, Tabrizi SJ, Tomlinson C, Messmer K, Korlipara LV, Schapira AH, Cooper JM. | 01/21/2010 |
| Mutant alpha-synuclein accumulation impairs short-term changes in synaptic strength when neurotransmitter availability is limited due to enhanced release probability or repetitive synaptic activity. | Altered short-term hippocampal synaptic plasticity in mutant alpha-synuclein transgenic mice.
Steidl JV, Gomez-Isla T, Mariash A, Ashe KH, Boland LM. | 01/21/2010 |
| proteasomal inhibition by aggregated alpha-synuclein could be mediated by interaction with S6'. | Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function.
Snyder H, Mensah K, Theisler C, Lee J, Matouschek A, Wolozin B. | 01/21/2010 |
| alpha-synuclein E46K mutation increases amyloid fibril formation | The E46K mutation in alpha-synuclein increases amyloid fibril formation.
Greenbaum EA, Graves CL, Mishizen-Eberz AJ, Lupoli MA, Lynch DR, Englander SW, Axelsen PH, Giasson BI. | 01/21/2010 |
| agrin has a role in binding alpha-synuclein and modulating alpha-synuclein fibrillation | Agrin binds alpha-synuclein and modulates alpha-synuclein fibrillation.
Liu IH, Uversky VN, Munishkina LA, Fink AL, Halfter W, Cole GJ. | 01/21/2010 |
| PD-related genetic modifications of human alpha-synuclein, parkin, and DJ-1 disrupt the mitochondrial function in C. elegans | Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.
Ved R, Saha S, Westlund B, Perier C, Burnam L, Sluder A, Hoener M, Rodrigues CM, Alfonso A, Steer C, Liu L, Przedborski S, Wolozin B., Free PMC Article | 01/21/2010 |
| A putative environmental pathogen capable of passing the gastric epithelial lining might induce alpha-synuclein misfolding and aggregation in specific cell types of the submucosal plexus and reach the brain via a consecutive series of projection neurons. | Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology.
Braak H, de Vos RA, Bohl J, Del Tredici K. | 01/21/2010 |
| Heat shock proteins may inhibit alpha-synuclein expression, accelerate alpha-synuclein degradation, thereby reducing the amount of alpha-synuclein protein and accordingly preventing its aggregation. | Heat shock proteins reduce alpha-synuclein aggregation induced by MPP+ in SK-N-SH cells.
Fan GH, Zhou HY, Yang H, Chen SD. | 01/21/2010 |
| These results suggest that in cells, alpha-syn is engaged in a fundamentally different mode of membrane interaction than the charge-dependent artificial membrane binding. | A novel mechanism of interaction between alpha-synuclein and biological membranes.
Kim YS, Laurine E, Woods W, Lee SJ. | 01/21/2010 |
| These results indicate that the C-terminal portion of the membrane-bound alpha-syn is quite rigid and structured, at variance from current models of the membrane-bound protein. | Conformational properties of the SDS-bound state of alpha-synuclein probed by limited proteolysis: unexpected rigidity of the acidic C-terminal tail.
de Laureto PP, Tosatto L, Frare E, Marin O, Uversky VN, Fontana A. | 01/21/2010 |
| The present investigation uncovers the detailed binding propensities between metals and alpha-synuclein and has biological implications in PD. | Thermodynamics imprinting reveals differential binding of metals to alpha-synuclein: relevance to Parkinson's disease.
Bharathi, Rao KS. | 01/21/2010 |
| study shows aggregated oligomeric alpha-synuclein is internalized by dopaminergic cells & causes detrimental morphological changes prior to cell death; one mechanism by which it mediates cell death is disruption of tubulin polymerization into microtubules | Oligomeric alpha-synuclein inhibits tubulin polymerization.
Chen L, Jin J, Davis J, Zhou Y, Wang Y, Liu J, Lockhart PJ, Zhang J. | 01/21/2010 |
| Casein kinase II (CKII) phosphorylates synphilin-1; beta subunit of this enzyme complex binds to synphilin-1. CKII-mediated phosphorylation of synphilin-1, rather than alpha-synuclein, modulates the aggregation into inclusion bodies. | Casein kinase II-mediated phosphorylation regulates alpha-synuclein/synphilin-1 interaction and inclusion body formation.
Lee G, Tanaka M, Park K, Lee SS, Kim YM, Junn E, Lee SH, Mouradian MM. | 01/21/2010 |
| role of aggregation by tissue transglutaminase in Lewy body formation in Parkinson's disease and dementia with Lewy bodies | Tissue transglutaminase-induced aggregation of alpha-synuclein: Implications for Lewy body formation in Parkinson's disease and dementia with Lewy bodies.
Junn E, Ronchetti RD, Quezado MM, Kim SY, Mouradian MM., Free PMC Article | 01/21/2010 |
| role in pathogenesis of Parkinson disease | [alpha-synuclein and Parkinson's disease].
Iwatsubo T. | 01/21/2010 |
| Alpha-synuclein protofibril is stabilized by a dopamine-alpha-synuclein adduct. | Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct.
Conway KA, Rochet JC, Bieganski RM, Lansbury PT Jr. | 08/21/2003 |
| Protofibrillar alpha-synuclein, in contrast to the monomeric and fibrillar forms, binds synthetic vesicles very tightly via a beta-sheet-rich structure, causing transient and potentially cytotoxic permeabilization. | Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease.
Volles MJ, Lee SJ, Rochet JC, Shtilerman MD, Ding TT, Kessler JC, Lansbury PT Jr. | 09/21/2001 |