GeneRIF Examples - Gene

Sample GeneRIFs

TP53 tumor protein p53 [Homo sapiens (human)]

Gene ID: 7157
GeneRIF: p53 tetramers induce rapid apoptosis and cell growth arrest, while a monomeric variant is functionally inactive, supporting cell growth.
PubMed Title: p53 oligomerization status modulates cell fate decisions between growth, arrest and apoptosis. Fischer NW, Prodeus A, Malkin D, Gariepy J.

Polg polymerase (DNA directed), gamma [Mus musculus (house mouse)]

Gene ID: 18975
GeneRIF: POLG-mutant mice exhibited characteristic behavioral phenotypes, distorted day-night rhythm and robust periodic activity pattern associated with estrous cycle. Abnormal behaviors were worsened by tricyclic antidepressants and improved by lithium.
PubMed Title: Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes. Kasahara T, Kubota M, Miyauchi T, Noda Y, Mouri A, Nabeshima T, Kato T.

Prkaca protein kinase cAMP-activated catalytic subunit alpha [Rattus norvegicus (Norway rat)]

Gene ID: 25636
GeneRIF: PKA regulates IP3R1 signaling with PP1 and PP2A in rat brain
PubMed Title: Protein kinase A and two phosphatases are components of the inositol 1,4,5-trisphosphate receptor macromolecular signaling complex. DeSouza N, Reiken S, Ondrias K, Yang YM, Matkovich S, Marks AR.

PHYB phytochrome B [Arabidopsis thaliana (thale cress)]

Gene ID: 816394
GeneRIF: PhyB inhibits the regulatory activity of PIF1 and PIF3 by releasing them from their DNA targets.
PubMed Title: Phytochrome B inhibits binding of phytochrome-interacting factors to their target promoters. Park E, Park J, Kim J, Nagatani A, Lagarias JC, Choi G.

Abl tyrosine kinase [Drosophila melanogaster (fruit fly)]

Gene ID: 45821
GeneRIF: Abl acts apically to suppress the accumulation of both Enabled (Ena) and actin in mesodermal cells during ventral furrow formation
PubMed Title: Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila. Fox DT, Peifer M.

Revised May 15, 2018