CPPED1 calcineurin like phosphoesterase domain containing 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CPPED1provided by HGNC
Official Full Name: calcineurin like phosphoesterase domain containing 1provided by HGNC
Primary source: HGNC:HGNC:25632
See related: Ensembl:ENSG00000103381 MIM:615603; AllianceGenome:HGNC:25632
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CSTP1
Summary: Predicted to enable metal ion binding activity and myosin phosphatase activity. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in spleen (RPKM 8.6), kidney (RPKM 8.5) and 24 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 16p13.12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (12659799..12803887, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (12696825..12840919, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (12753656..12897744, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

functions regulated by CPPED1 in trophoblasts at choriodecidual interphase have a role in the induction of term labour, but it may be independent of AKT1.
Title: Expression of CPPED1 in human trophoblasts is associated with timing of term birth.
CPPED1 is involved in glucose uptake in adipocytes
Title: Downregulation of CPPED1 expression improves glucose metabolism in vitro in adipocytes.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

D8S2279 (e-PCR)
- UniSTS:473907

D1S1361 (e-PCR)
- UniSTS:149557

RH75489 (e-PCR)
- UniSTS:84533

SHGC-149384 (e-PCR)
- UniSTS:176971

G09525 (e-PCR)
- UniSTS:3166

RH64955 (e-PCR)
- UniSTS:86632

D1S1423 (e-PCR)
- UniSTS:149619

SHGC-60589 (e-PCR)
- UniSTS:10121

SHGC-63005 (e-PCR)
- UniSTS:95387

SHGC-32705 (e-PCR)
- UniSTS:45483

RH47201 (e-PCR)
- UniSTS:87227

D16S2653 (e-PCR)
- UniSTS:152260

SHGC-68496 (e-PCR)
- UniSTS:95439

SHGC-10868 (e-PCR)
- UniSTS:53207

RH47159 (e-PCR)
- UniSTS:90856

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in azurophil granule lumen	TAS Traceable Author Statement more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in plasma membrane	IDA Inferred from Direct Assay more info

General protein information

Go to the top of the page Help

Preferred Names: serine/threonine-protein phosphatase CPPED1

Names: calcineurin-like phosphoesterase domain-containing protein 1; complete S-transactivated protein 1

NP_001092925.1

EC 3.1.3.16

NP_060810.2

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099455.2 → NP_001092925.1 serine/threonine-protein phosphatase CPPED1 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.

Source sequence(s)

AC010333, AC092324

Consensus CDS

CCDS42119.1

UniProtKB/Swiss-Prot

Q9BRF8

Related

ENSP00000411127.2, ENST00000433677.6

Conserved Domains (1) summary

cl13995
Location:29 → 153

MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
NM_018340.3 → NP_060810.2 serine/threonine-protein phosphatase CPPED1 isoform a

See identical proteins and their annotated locations for NP_060810.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AC010333, AC092324

Consensus CDS

CCDS42120.1

UniProtKB/Swiss-Prot

B4DQ68, Q6MZY9, Q9BRF8, Q9H9M9, Q9NUT6

Related

ENSP00000371193.4, ENST00000381774.9

Conserved Domains (2) summary

COG1409
Location:67 → 269

CpdA; 3',5'-cyclic AMP phosphodiesterase CpdA [Signal transduction mechanisms]

cd07395
Location:29 → 295

MPP_CSTP1; Homo sapiens CSTP1 and related proteins, metallophosphatase domain