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    Sbno1 strawberry notch homolog 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304470, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sbno1provided by RGD
    Official Full Name
    strawberry notch homolog 1provided by RGD
    Primary source
    RGD:1310005
    See related
    EnsemblRapid:ENSRNOG00000001064 AllianceGenome:RGD:1310005
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chromatin DNA binding activity and histone binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to human SBNO1 (strawberry notch homolog 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 184.1), Kidney (RPKM 179.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sbno1 in Genome Data Viewer
    Location:
    12q15
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (37835306..37895861)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (32175176..32234200)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (37593692..37650761)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene Rab interacting lysosomal protein-like 2 Neighboring gene lysine methyltransferase 5A Neighboring gene cyclin-dependent kinase 2 associated protein 1 Neighboring gene mitochondrial translation release factor in rescue

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein strawberry notch homolog 1
    Names
    sno, strawberry notch homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001389247.1 → NP_001376176.1  protein strawberry notch homolog 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q5BJL5
      UniProtKB/TrEMBL
      A0A0G2K3C0, F1LS26
      Related
      ENSRNOP00000054711.4, ENSRNOT00000057902.5
      Conserved Domains (2) summary
      pfam13871
      Location:871 → 1147
      Helicase_C_4; C-terminal domain on Strawberry notch homolog
      pfam13872
      Location:257 → 559
      AAA_34; P-loop containing NTP hydrolase pore-1

    2. NM_001389248.1 → NP_001376177.1  protein strawberry notch homolog 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q5BJL5
      UniProtKB/TrEMBL
      A0A0G2K3C0, A0A8I6ATT9
      Related
      ENSRNOP00000097893.1, ENSRNOT00000102429.2
      Conserved Domains (2) summary
      pfam13871
      Location:836 → 1112
      Helicase_C_4; C-terminal domain on Strawberry notch homolog
      pfam13872
      Location:222 → 524
      AAA_34; P-loop containing NTP hydrolase pore-1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      37835306..37895861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089440.2 → XP_038945368.1  protein strawberry notch homolog 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5BJL5
      UniProtKB/TrEMBL
      A0A0G2K3C0

    2. XM_039089441.2 → XP_038945369.1  protein strawberry notch homolog 1 isoform X2

      UniProtKB/Swiss-Prot
      Q5BJL5
      UniProtKB/TrEMBL
      A0A0G2K3C0
      Conserved Domains (2) summary
      pfam13871
      Location:870 → 1146
      Helicase_C_4; C-terminal domain on Strawberry notch homolog
      pfam13872
      Location:256 → 558
      AAA_34; P-loop containing NTP hydrolase pore-1

    3. XM_006249301.5 → XP_006249363.1  protein strawberry notch homolog 1 isoform X3

      UniProtKB/Swiss-Prot
      Q5BJL5
      UniProtKB/TrEMBL
      A0A0G2K3C0
      Conserved Domains (2) summary
      pfam13871
      Location:870 → 1146
      Helicase_C_4; C-terminal domain on Strawberry notch homologue
      pfam13872
      Location:256 → 558
      AAA_34; P-loop containing NTP hydrolase pore-1

    4. XM_039089442.2 → XP_038945370.1  protein strawberry notch homolog 1 isoform X4

      UniProtKB/Swiss-Prot
      Q5BJL5
      UniProtKB/TrEMBL
      A0A0G2K3C0
      Conserved Domains (2) summary
      pfam13871
      Location:836 → 1112
      Helicase_C_4; C-terminal domain on Strawberry notch homolog
      pfam13872
      Location:222 → 524
      AAA_34; P-loop containing NTP hydrolase pore-1

    5. XM_039089443.2 → XP_038945371.1  protein strawberry notch homolog 1 isoform X5

      UniProtKB/Swiss-Prot
      Q5BJL5
      UniProtKB/TrEMBL
      A0A0G2K3C0
      Conserved Domains (2) summary
      pfam13871
      Location:835 → 1111
      Helicase_C_4; C-terminal domain on Strawberry notch homolog
      pfam13872
      Location:221 → 523
      AAA_34; P-loop containing NTP hydrolase pore-1

    6. XM_063271301.1 → XP_063127371.1  protein strawberry notch homolog 1 isoform X1

    7. XM_063271302.1 → XP_063127372.1  protein strawberry notch homolog 1 isoform X2

    8. XM_039089444.2 → XP_038945372.1  protein strawberry notch homolog 1 isoform X6

      UniProtKB/Swiss-Prot
      Q5BJL5
      Conserved Domains (2) summary
      pfam13871
      Location:665 → 941
      Helicase_C_4; C-terminal domain on Strawberry notch homolog
      pfam13872
      Location:51 → 353
      AAA_34; P-loop containing NTP hydrolase pore-1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107138.1: Suppressed sequence

      Description
      NM_001107138.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BJL5.2 GenPept UniProtKB/Swiss-Prot:Q5BJL5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials